Blar i Department of Biomedicine på tittel

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    • Shanks - multidomain molecular scaffolds of the postsynaptic density 

      Kursula, Petri (Peer reviewed; Journal article, 2019-03-06)
      The postsynaptic density (PSD) is a protein-rich assembly below the postsynaptic membrane, formed of large scaffolding proteins. These proteins carry a combination of protein interaction domains, which may interact with ...

    • Shedding light on black boxes in protein identification 

      Vaudel, Marc; Venne, A. Saskia; Berven, Frode; Zahedi, René P.; Martens, Lennart; Barsnes, Harald (Peer reviewed; Journal article, 2014-05)
      Performing a well thought-out proteomics data analysis can be a daunting task, especially for newcomers to the field. Even researchers experienced in the proteomics field can find it challenging to follow existing publication ...

    • Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease 

      Bjørkkjær, Tormod; Brun, Johan Gorgas; Valen, Merete; Arslan, Gülen; Lind, Ragna Anne; Brunborg, Linn Anne; Berstad, Arnold; Frøyland, Livar (Peer reviewed; Journal article, 2006-03-20)
      Background: A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10- day) duodenal administration of ...

    • A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons 

      Ishizuka, Yuta; Bramham, Clive R. (Peer reviewed; Journal article, 2019-03)
      Background Primary neuronal cultures are widely used to elucidate fundamental aspects of neuronal anatomy, physiology, cell biology, and neuronal dysfunction in animal models of disease. However, preparation of primary ...

    • Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors 

      Enger, Marianne (Master thesis, 2014-02-28)
      The thesis has the title Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors". Flow cytometry enables complex biochemical signaling networks to be determined in ...

    • SLC25A51 is a mammalian mitochondrial NAD+ transporter 

      Luongo, Timothy S.; Eller, Jared M.; Lu, Mu-Jie; Niere, Marc; Raith, Fabio; Perry, Caroline; Bornstein, Marc R.; Oliphint, Paul; Wang, Lin; McReynolds, Melanie R.; Migaud, Marie E.; Rabinowitz, Joshua D.; Johnson, F. Brad; Johnsson, Kai; Ziegler, Mathias; Cambronne, Xiaolu A.; Baur, Joseph A. (Journal article; Peer reviewed, 2020)
      Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in ...

    • Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress 

      Grønli, Janne; Soule, Jonathan; Bramham, Clive R. (Peer reviewed; Journal article, 2014-01-21)
      Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic ...

    • Smart Suture with Iodine Contrasting Nanoparticle for Computed Tomography 

      Houshyar, Shadi; Yin, Hong; Pope, Leon; Zizhou, Rumbidzai; Dekiwadia, Chaitali; Hill-Yardin, Elisa; Yeung, Justin; John, Sabu; Fox, Kate; Tran, Nhiem; Cole, Ivan; Elbourne, Aaron; Truong, Vi Khanh; Truskewycz, Adam Leo (Journal article, 2023)
      Surgical site infections (SSI) are amongst the most common medical infections, occurring in 2 to 4% of patients undergoing a surgical procedure. Smart surgical sutures can play an important role in preventing infection. ...

    • Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities 

      Beavo, Joseph A.; Bos, Johannes L.; Butt, Elke; Døskeland, Stein Ove; Genieser, Hans-Gottfried; Hinds, Thomas R.; Poppe, Heiko; Rehmann, Holger; Rybalkin, Sergei D.; Schwede, Frank; Tang, Xiao-Bo (Conference lecture, 2007-07-25)

    • SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner 

      Zhang, Shouji; Zhao, Shulin; Qi, Yanhua; Li, Boyan; Wang, Huizhi; Pan, Ziwen; Xue, Hao; Jin, Chuandi; Qiu, Wei; Chen, Zihang; Guo, Qindong; Fan, Yang; Xu, Jianye; Gao, Zijie; Wang, Shaobo; Guo, Xing; Deng, Lin; Ni, Shilei; Xue, Fuzhong; Wang, Jian; Zhao, Rongrong; Li, Gang (Journal article; Peer reviewed, 2022)
      As one of the most common post-transcriptional modifications of mRNAs and noncoding RNAs, N6-methyladenosine (m6A) modification regulates almost every aspect of RNA metabolism. Evidence indicates that dysregulation of m6A ...

    • Stability and flexibility of full-length human oligodendrocytic QKI6 

      Raasakka, Arne; Kursula, Petri (Peer reviewed; Journal article, 2019-09-23)
      Objective: Oligodendrocytes account for myelination in the central nervous system. During myelin compaction, key proteins are translated in the vicinity of the myelin membrane, requiring targeted mRNA transport. Quaking ...

    • Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme 

      Bezem, Maria Teresa; Baumann, Anne; Skjærven, Lars; Meyer, Romain; Kursula, Petri; Martinez, Aurora; Flydal, Marte Innselset (Peer reviewed; Journal article, 2016-07-27)
      Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ...

    • Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p 

      Weiner, Daniel J.; Ling, Emi; Erdin, Serkan; Tai, Derek J. C.; Yadav, Rachita; Grove, Jakob; Fu, Jack M.; Nadig, Ajay; Carey, Caitlin E.; Baya, Nikolas; Bybjerg-Grauholm, Jonas; Mortensen, Preben B.; Werge, Thomas; Demontis, Ditte; Mors, Ole; Nordentoft, Merete; Als, Thomas D.; Baekvad-Hansen, Marie; Rosengren, Anders; Havdahl, Alexandra Karoline Saasen; Hedemand, Anne; Palotie, Aarno; Chakravarti, Aravinda; Arking, Dan; Sulovari, Arvis; Starnawska, Anna; Thiruvahindrapuram, Bhooma; de Leeuw, Christiaan; Carey, Caitlin; Ladd-Acosta, Christine; van der Merwe, Celia; Devlin, Bernie; Cook, Edwin H.; Eichler, Evan; Corfield, Elizabeth Claire; Dieleman, Gwen; Schellenberg, Gerard; Hakonarson, Hakon; Coon, Hilary; Dziobek, Isabel; Vorstman, Jacob; Girault, Jessica; Sutcliffe, James S.; Duan, Jinjie; Nurnberger, John; Hallmayer, Joachim; Buxbaum, Joseph; Piven, Joseph; Weiss, Lauren; Davis, Lea; Janecka, Magdalena; Mattheisen, Manuel; State, Matthew W.; Gill, Michael; Daly, Mark; Uddin, Mohammed; Andreassen, Ole; Szatmari, Peter; Lee, Phil Hyoun; Anney, Richard; Ripke, Stephan; Satterstrom, Kyle; Santangelo, Susan; Kuo, Susan; van Elst, Ludger Tebartz; Rolland, Thomas; Bougeron, Thomas; Polderman, Tinca; Turner, Tychele; Underwood, Jack; Manikandan, Veera; Pillalamarri, Vamsee; Warrier, Varun; Philipsen, Alexandra; Reif, Andreas; Hinney, Anke; Cormand, Bru; Bau, Claiton H. D.; Rovaris, Diego Luiz; Sonuga-Barke, Edmund; Grevet, Eugenio Horacio; Salum, Giovanni; Larsson, Henrik Bo W.; Buitelaar, Jan; Haavik, Jan; McGough, James; Kuntsi, Jonna; Elia, Josephine; Lesch, Klaus-Peter; Klein, Marieke; Bellgrove, Mark; Tesli, Martin Steen; Leung, Patrick W. L.; Pan, Pedro M.; Dalsgaard, Søren; Loo, Sandra; Medland, Sarah; Faraone, Stephen; Reichborn-Kjennerud, Ted; Banaschewski, Tobias; Hawi, Ziarih; Berretta, Sabina; Macosko, Evan Z.; Sebat, Jonathan; O’Connor, Luke J.; Hougaard, David M.; Børglum, Anders D.; Talkowski, Michael E.; McCarroll, Steven A.; Robinson, Elise B. (Journal article; Peer reviewed, 2022)
      The canonical paradigm for converting genetic association to mechanism involves iteratively mapping individual associations to the proximal genes through which they act. In contrast, in the present study we demonstrate the ...

    • Stedcellenes fyringsmønster under påvirkning av belønning og forsøksapparatets geometri 

      Karlsen, Pernille (Master thesis, 2004)
      I hippocampus hos rotter finner man en type nerveceller som aktiveres stedspesifikt. Dette innebærer at de kun er aktive når rotten er i et bestemt område av omgivelsene. Disse cellene kalles stedceller (en: "place cells") ...

    • Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment 

      Dirkse, Anna; Golebiewska, Anna; Buder, Thomas; Nazarov, Petr V.; Muller, Arnaud; Poovathingal, Suresh K.; Brons, Nicolaas H. C.; Leite, Sonia; Sauvageot, Nicolas; Sarkisjan, Dzjemma; Seyfrid, Mathieu; Fritah, Sabrina; Stieber, Daniel; Michelucci, Alesandro; Hertel, Frank; Herold-Mende, Christel; Azuaje, Francisco; Skupin, Alexander; Bjerkvig, Rolf; Deutsch, Andreas; Voss-Böhme, Anja; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2019-04-16)
      The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma ...

    • Stimulant treatment profiles predicting co-occurring substance use disorders in individuals with attention-deficit/hyperactivity disorder 

      Groenman, Annabeth P.; Schweren, Lizanne J.S.; Weeda, Wouter; Luman, Marjolein; Noordermeer, Siri D S; Heslenfeld, Dirk J; Franke, Barbara; Faraone, Stephen V.; Rommelse, Nanda; Hartman, Catharina A; Hoekstra, Pieter J; Buitelaar, Jan; Oosterlaan, Jaap (Peer reviewed; Journal article, 2019-02-05)
      Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of developing substance use disorders (SUDs) and nicotine dependence (ND). It remains unclear whether and how stimulant treatment may ...

    • Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy 

      Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne (Peer reviewed; Journal article, 2016-01)
      Background and aims: Peripheral neuropathic pain is described as a pain state caused by an injury or dysfunction of the nervous system, and could have clinical manifestations such as hyperalgesia, allodynia and spontaneous ...

    • Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression 

      PRIMAC, I; MAQUOI, E; BLACHER, S; HELJASVAARA, R; Van Deun, Jan; Smeland, Hilde Ytre-Hauge; CANALE, A; LOUIS, T; Stuhr, Linda Elin Birkhaug; SOUNNI, NE; CATALDO, D; PIHLAJANEMI, T; PEQUEUX, C; DE WEAVER, O; Gullberg, Donald; Noel, Agnes (Peer reviewed; Journal article, 2019)
      Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ–positive CAF subset displaying tumor-promoting ...

    • Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors 

      Smeland, Hilde Ytre-Hauge; Lu, Ning; Karlsen, Tine Veronica; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2019-03-15)
      Background: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the ...

    • Stromal integrin α11β1 affects RM11 prostate and 4T1 breast xenograft tumors differently 

      Reigstad, Inga; Smeland, Hilde Ytre-Hauge; Skogstrand, Trude; Sortland, Kristina; Schmid, Caroline; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2016-03-18)
      Purpose It has been implied that the collagen binding integrin α11β1 plays a role in carcinogenesis. As still relatively little is known about how the stromal integrin α11β1 affects different aspects of tumor development, ...