Browsing Department of Biomedicine by Title
Now showing items 685-704 of 773
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A study on metabolic rewiring in cancer cell plasticity
(Doctoral thesis, 2020-08-21)Adaptation of cellular energetics is an important feature of tumorigenesis as a vast supply of nutrients is needed to accommodate increased growth. Essential energy pathways includes glucose, fatty acid and amino acid ... -
Study preferences and exam outcomes in medical education: insights from renal physiology
(Journal article; Peer reviewed, 2024)Background Efficient learning strategies and resource utilization are critical in medical education, especially for complex subjects like renal physiology. This is increasingly important given the rise in chronic renal ... -
The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis
(Journal article; Peer reviewed, 2022)Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release
(Journal article; Peer reviewed, 2023)Epstein-Barr virus (EBV) replicates its genome in the nucleus and undergoes tegumentation and envelopment in the cytoplasm. We are interested in how the single-stranded DNA binding protein BALF2, which executes its function ... -
Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein
(Peer reviewed; Journal article, 2010-11-21)Background The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is ... -
Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects
(Journal article; Peer reviewed, 2020)Suicide gene therapy has represented an experimental cancer treatment modality for nearly 40 years. Among the various cancers experimentally treated by suicide gene therapy, high-grade gliomas have been the most prominent ... -
Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
(Journal article; Peer reviewed, 2023)With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red ... -
Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy
(Peer reviewed; Journal article, 2017)Surgical resection is a standard component of treatment in the clinical management of patients with glioblastoma multiforme (GBM). However, experimental therapies are rarely investigated in the context of tumor debulking ... -
Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
(Journal article; Peer reviewed, 2022)Background Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its ... -
Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions
(Journal article; Peer reviewed, 2023-02-02)Therapy of recurrent glioblastoma (GBM) is challenging due to lack of standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic and predictive factors for survival in GBM patients from ... -
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
(Peer reviewed; Journal article, 2010-06-01)Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers in man. Despite technological advances in surgical management, combined regimens of radiotherapy with ... -
Synthetic corticosteroids as tryptophan hydroxylase stabilizers
(Journal article; Peer reviewed, 2021)Background: Clinically, corticosteroids are used mainly for their immune-modulatory properties but are also known to influence mood. Despite evidence of a role in regulating tryptophan hydroxylases (TPH), key enzymes in ... -
Targeting APLN/APLNR improves antiangiogenic efficiency and blunts proinvasive side effects of VEGFA/VEGFR2 blockade in glioblastoma
(Peer reviewed; Journal article, 2019)Antiangiogenic therapy of glioblastoma (GBM) with bevacizumab, a VEGFA-blocking antibody, may accelerate tumor cell invasion and induce alternative angiogenic pathways. Here we investigate the roles of the proangiogenic ... -
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
(Peer reviewed; Journal article, 2013-09-09)Glioblastoma (GBM) is the most malignant brain tumor where patients’ survival is only 14.6 months, despite multimodal therapy with debulking surgery, concurrent chemotherapy and radiotherapy. There is an urgent, unmet need ... -
Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
(Journal article; Peer reviewed, 2020)Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to ... -
Targeting the AKT Pathway in Glioblastoma Multiforme
(Master thesis, 2016-06-01)In this study, the therapeutic efficacy of AKT allosteric and ATP competitive inhibitors was investigated in EGFR-amplified SKMG-3 and EGFR-low U-87 cell lines. The IC50 values of AKT inhibitors were determined by cellular ... -
Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4. A novel strategy to reveal glioblastoma to the immune system
(Doctoral thesis, 2013-06-19)Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. The patients’ median survival is only 14.6 months despite multimodal treatment, including surgery and concomitant radiation and chemotherapy. ...