Browsing Department of Biomedicine by Title

Now showing items 81-100 of 812

    • Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival 

      Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-08-15)
      Background Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O6-methyl guanine DNA methyltransferase (MGMT) that is often characterised by unmethylated promoter. Here, ...

    • Brain asymmetries from mid- to late life and hemispheric brain age 

      Korbmacher, Max; van der Meer, Dennis; Beck, Dani; Lange, Ann-Marie Glasø de; Eikefjord, Eli Nina Hølleland; Lundervold, Arvid; Andreassen, Ole; Westlye, Lars Tjelta; Maximov, Ivan (Journal article; Peer reviewed, 2024)
      The human brain demonstrates structural and functional asymmetries which have implications for ageing and mental and neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from ...

    • Brain Computer Interface - Neurophysiology and Experimental Examples 

      Leidland, Einar (Master thesis, 2011-07-20)
      The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ...

    • Brain‐wide associations between white matter and age highlight the role of fornix microstructure in brain ageing 

      Korbmacher, Max; de Lange, Ann-Marie; van der Meer, Dennis; Beck, Dani; Eikefjord, Eli Nina; Lundervold, Arvid; Andreassen, Ole; Westlye, Lars Tjelta; Maximov, Ivan (Journal article; Peer reviewed, 2023)
      Unveiling the details of white matter (WM) maturation throughout ageing is a fundamental question for understanding the ageing brain. In an extensive comparison of brain age predictions and age-associations of WM features ...

    • Breaking boundaries: A rare case of glioblastoma with uncommon extraneural metastases: A case report and literature review 

      Taule, Erlend Moen; Brekke, Jorunn; Miletic, Hrvoje; Sætran, Hege Aase; Maric, Snezana; HogenEsch, Ineke; Mahesparan, Rupavathana (Journal article; Peer reviewed, 2024)
      Introduction Extraneural metastases (ENM) from glioblastoma (GBM) remain extremely rare with only a scarce number of cases described in the literature. The lack of cases leads to no consensus on the optimal treatment and ...

    • Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures 

      Kennedy, Eamonn; Vadlamani, Shashank; Lindsey, Hannah M.; Lei, Pui-Wa; Jo-Pugh, Mary; Thompson, Paul M.; Tate, David F.; Hillary, Frank G.; Dennis, Emily L.; Wilde, Elisabeth A.; Zunta-Soares, Giovana B.; Yatham, Lakshmi N.; Wylie, Glenn R.; Wu, Mon-Ju; Wroblewski, Adrian; Wild, Krista; Westlye, Lars Tjelta; Werden, Emilio; Walker, William C.; Vivash, Lucy; Vilella, Elisabet; Umpierrez, Guillermo; Ulrichsen, Kristine Moe; Turner, Jessica A.; Troyanskaya, Maya; Torres, Ivan; Tone, Erin; Thomopoulos, Sophia I.; Thomas-Odenthal, Florian; Thames, April; Straube, Benjamin; Stein, Frederike; Stasenko, Alena; Španiel, Filip; Spalleta, Gianfranco; Soares, Jair C.; Schmidt, Andre; Sanders, Anne-Marthe; Salvador, Raymond; Ryan, Nicholas P.; Rowland, Jared; Rootes-Murdy, Kelly; Rodriguez, Mabel; Rodriguez, Jonathan; Richard, Geneviève; Repple, Jonathan; Pomarol-Clotet, Edith; Piras, Federica; Piras, Fabrizio; Parent, Marise; Pardoe, Heath; Ozmen, Mustafa; de la Foz, Victor Ortiz García; Olsen, Alexander; Ollinger, John; Oertel, Viola; O’Brien, Terence; Nunes, Abraham; Newsome, Mary R.; Nenadić, Igor; Myall, Daniel J.; Mwangi, Benson; Morey, Rajendra A.; Michel, Chantal; Merchán-Naranjo, Jessica; Melzer, Tracy R.; Meinert, Susanne; McDonald, Carrie R.; Mayeli, Ahmad; Mattos, Paulo; Marquardt, Craig A.; Marotta, Cassandra; Lundervold, Astri J.; Løvstad, Marianne; Lippa, Sara M.; Liou-Johnson, Victoria; Liebel, Spencer W.; Lengenfelder, Jean; Lee, Jungha; Laskowitz, Sarah; Langella, Roberto; Kwon, Jun Soo; Kumari, Veena; Kuhn, Taylor; Kremen, William S.; Krch, Denise; Kolskår, Knut-Kristian; Knížková, Karolina; Kircher, Tilo; Kindler, Jochen; Kim, Minah; Khlif, Mohamed Salah; Kenney, Kimbra; Kang, Xiaojian; Kaess, Michael; Jansen, Andreas; Irimia, Andrei; Hubl, Daniela; Hoskinson, Kristen R.; Hinkin, Charles; Haavik, Jan; Ha, Minji; Gutierrez-Zotes, Alfonso; Gruber, Marius; Grotegerd, Dominik; Goltermann, Janik; Giza, Christopher C.; Genova, Helen; Fuentes-Claramonte, Paola; Franz, Carol; Frank, Lea E.; Ferrarelli, Fabio; Esopenko, Carrie; Ehrlich, Stefan; Dobryakova, Ekaterina; Disner, Seth G.; Diaz-Caneja, Covadonga M.; DeLuca, John; Davenport, Nicholas; Darby, David; Dannlowski, Udo; Dams-O’Connor, Kristen; Dalrymple-Alford, John C.; Crespo-Facorro, Benedicto; Cifu, David X.; Chiaravalloti, Nancy D.; Calhoun, Vince D.; Caeyenberghs, Karen; Brosch, Katharina; Brodtmann, Amy; Borgwardt, Stefan; Bird, Laura J.; Banaj, Nerisa; Babikian, Talin; Ayesa-Arriola, Rosa; Avram, Mihai; Asarnow, Robert F.; Arango, Celso; Anderson, Tim J.; Ambrogi, Sonia; Alonso-Lana, Silvia; Alda, Martin; Adamson, Maheen (Journal article; Peer reviewed, 2024)
      Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. These efforts unveil new questions about how to integrate data across distinct sources and ...

    • C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer 

      Liu, Xiaozheng; Rulina, Anastasiia; Choi, Man Hung; Pedersen, Line; Lepland, Johanna; Takle, Sina Thorsen; Madeleine, Noëlly; Peters, Stacey D'mello; Wogsland, Cara Ellen; Grøndal, Sturla Magnus; Lorens, James Bradley; Goodarzi, Hani; Lønning, Per Eystein; Knappskog, Stian; Molven, Anders; Halberg, Nils Henrik (Journal article; Peer reviewed, 2022)
      Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer ...

    • Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways 

      Mannsåker, Trond Are; Hoang, Tuyen; Aasen, Synnøve Nymark; Bjørnstad, Ole Vidhammer; Parajuli, Himalaya; Sundstrøm, Terje; Thorsen, Frits (Journal article; Peer reviewed, 2021-11-14)
      Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma ...

    • Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines 

      Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)
      Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...

    • Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma 

      Yabo, Yahaya A.; Niclou, Simone Pierrette; Golebiewska, Anna (Journal article; Peer reviewed, 2022)
      Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells display prominent intrinsic plasticity and ...

    • Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies 

      Sakariassen, Per Øystein; Immervoll, Heike; Chekenya, Martha (Peer reviewed; Journal article, 2007-11)
      Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ...

    • Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins 

      Zeltz, Cedric; Primac, Irina; Murugan Erusappan, Pugazendhi; Alam, Jahedul; Noel, Agnes; Gullberg, Donald (Peer reviewed; Journal article, 2019)
      The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle ...

    • A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study 

      Hegvik, Tor-Arne; Jacobsen, Kaya Kvarme; Fredriksen, Mats; Zayats, Tetyana; Haavik, Jan (Peer reviewed; Journal article, 2016-08)
      Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate ...

    • Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study 

      Hartveit, Espen; Veruki, Margaret Lin; Zandt, Bas-Jan (Peer reviewed; Journal article, 2019-08-04)
      Exocytotic release of neurotransmitter can be quantified by electrophysiological recording from postsynaptic neurons. Alternatively, fusion of synaptic vesicles with the cell membrane can be measured as increased capacitance ...

    • Capacitance measurements of exocytosis from AII amacrine cells in retinal slices 

      Hartveit, Espen; Veruki, Margaret Lin (Journal article; Peer reviewed, 2025)
      During neuronal synaptic transmission, the exocytotic release of neurotransmitters from synaptic vesicles in the presynaptic neuron evokes a change in conductance for one or more types of ligand-gated ion channels in the ...

    • Carbon Dot Therapeutic Platforms: Administration, Distribution, Metabolism, Excretion, Toxicity, and Therapeutic Potential 

      Truskewycz, Adam Leo; Yin, Hong; Halberg, Nils Henrik; Lai, Daniel T. H.; Ball, Andrew S.; Truong, Vi Khanh; Rybicka, Agata; Cole, Ivan (Journal article; Peer reviewed, 2022)
      Ultrasmall nanoparticles are often grouped under the broad umbrella term of “nanoparticles” when reported in the literature. However, for biomedical applications, their small sizes give them intimate interactions with ...

    • Cardiac Involvement in Systemic and Local Vasculitides: The Value of Noninvasive Multimodality Imaging 

      Mohamed Ali, Abukar; Yakupoglu, H. Yakup; Fuchs, Tobias A.; Larsen, Terje Hjalmar; Aukrust, Pål; Gunnarsson, Ragnar; Saeed, Sahrai (Journal article; Peer reviewed, 2023)
      Despite significant advances in managing systemic vasculitides, cardiovascular morbidity, and mortality are still of primary concern. Advances in noninvasive imaging have broadened our understanding of the clinical ...

    • Case report: ADHD and prognosis in tyrosinemia type 1 

      Halleland, Helene; Elgen, Irene Bircow; Bliksrud, Yngve Thomas; Hansen, Eirik Vangsøy; Skavhellen, Rita Rigmor; Furevik, Magne Ivar; Haavik, Jan (Journal article; Peer reviewed, 2023-07-18)
      Neurometabolic disorders such as tyrosinemia type 1 (TYRSN1) may interfere with brain metabolism and show symptoms of attention-deficit hyperactivity disorder (ADHD) in patients treated with the enzyme inhibitor nitisinone ...

    • Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum 

      Akaddar, Aziza; Doderer-Lang, Cécile; Marzahn, Melissa R.; Delalande, François; Mousli, Marc; Helle, Karen Blaauw; Dorsselaer, Alain; Aunis, Dominique; Dunn, Ben M.; Metz-Boutigue, Marie-Hélène; Candolfi, Ermanno (Peer reviewed; Journal article, 2010-02-23)
      Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides on ...

    • CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells 

      Reigstad, Agathe; Herdlevær, Christina Frantzen; Rigg, Emma Kayleigh; Hoang, Tuyen; Bjørnstad, Ole Vidhammer; Aasen, Synnøve Nymark; Preis, Jasmin; Haan, Claude; Sundstrøm, Terje; Thorsen, Frits (Journal article; Peer reviewed, 2022)
      Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase ...