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Blar i Department of Biomedicine på tittel 
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  • Department of Biomedicine
  • Blar i Department of Biomedicine på tittel
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  • Blar i Department of Biomedicine på tittel
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Blar i Department of Biomedicine på tittel

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    • Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood 

      Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga Birgitte; Wiig, Helge; Tenstad, Olav (Peer reviewed; Journal article, 2014-12)
      Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ...
    • Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism 

      Yadetie, Fekadu; Bjørneklett, Silje; Garberg, Hilde K; Oveland, Eystein; Berven, Frode; Goksøyr, Anders; Karlsen, Odd André (Peer reviewed; Journal article, 2016-08-05)
      Background: Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we ...
    • Quantitative Analysis of Magnetic Resonance Diffusion Tensor Imaging of the Human Brain – The effect of varying number of acquisitions and number of diffusion sensitizing directions 

      Oppedal, Ketil (Master thesis, 2005)
    • Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls 

      Berge, Tone; Eriksson, Anna; Brorson, Ina Skaara; Høgestøl, Einar August; Berg-Hansen, Pål; Døskeland, Anne Marie Simonne; Mjaavatten, Olav; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Berven, Frode (Peer reviewed; Journal article, 2019-05-08)
      Background Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammation ...
    • A randomized double blind comparison of short-term duodenally administrated whale and seal blubber oils in patients with inflammatory bowel disease and joint pain 

      Bjørkkjær, Tormod; Araujo, Pedro; Madland, Tor Magne; Berstad, Arnold; Frøyland, Livar (Peer reviewed; Journal article, 2009)
      Compared with soy oil, 10 days treatment with seal oil (SO), 10 mL×3 daily, self-administrated through a nasoduodenal feeding tube, relieves joint pain in patients with inflammatory bowel disease (IBD). This randomized, ...
    • Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. 

      Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; Jacobsen, Hege Karine; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian (Peer reviewed; Journal article, 2014-12)
      Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ...
    • Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity 

      Kouloulia, Stella; Hallin, Erik Ingmar; Simbriger, Konstanze; Amorim, Ines S; Lach, Gilliard; Amvrosiadis, Theoklitos; Chalkiadaki, Kleanthi; Kampaite, Agniete; Truong, Vinh Tai; Hooshmandi, Mehdi; Jafarnejad, Seyed Mehdi; Skehel, Paul; Kursula, Petri; Khoutorsky, Arkady; Gkogkas, Christos (Peer reviewed; Journal article, 2019)
      The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central ...
    • A rat model of radiation injury in the mandibular area 

      Sønstevold, Tonje; Johannessen, Anne Christine; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2015-06-09)
      Background Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding ...
    • Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2 

      Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni (Peer reviewed; Journal article, 2015-01-15)
      Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ...
    • Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma. 

      Feng, Zichao; Zhou, Wenjing; Wang, Jiwei; Qi, Qichao; Han, Mingzhi; Kong, Yang; Hu, Yaotian; Zhang, Yulin; Chen, Anbin; Huang, Bin; Zhang, Di; Li, Wenjie; Zhang, Qing; Bjerkvig, Rolf; Wang, Jian; Thorsen, Frits; Li, Xingang (Peer reviewed; Journal article, 2019-11-28)
      Proteolipid protein 2 (PLP2) is an integral ion channel membrane protein of the endoplasmic reticulum. The protein has been shown to be highly expressed in many cancer types, but its importance in glioma progression is ...
    • Reduced Granulation Tissue and Wound Strength in the Absence of α11β1 Integrin 

      Schulz, Jan-Niklas; Zeltz, Cedric; Sørensen, Ida Wiig; Barczyk, Malgorzata; Carracedo, Sergio; Hallinger, Ralf; Niehoff, Anja; Eckes, Beate; Gullberg, Donald (Peer reviewed; Journal article, 2015-12-08)
      Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement of another collagen receptor in this process. Our previous ...
    • Reduced Joint Pain after Short-term Duodenal Administration of Seal Oil in Patients with Inflammatory Bowel Disease: Comparison with Soy Oil 

      Bjørkkjær, Tormod; Brunborg, Linn Anne; Arslan, Gülen; Lind, Ragna Anne; Brun, Johan Gorgas; Valen, Merete; Klementsen, Beate; Berstad, Arnold; Frøyland, Livar (Peer reviewed; Journal article, 2004)
      Background: Rheumatic joint pain is a common extraintestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, ...
    • Regulation and function of tumor suppressor p53 isoforms beta and gamma in Acute Myeloid Leukemia 

      Ha, Quang Trung (Master thesis, 2013-06-01)
      Research has proposed that the C-terminal truncated p53 isoforms beta and gamma enhance chemosensitivity in p53(null) cancer cell lines. Their high expression in acute myeloid leukemia (AML) patients correlates positively ...
    • Regulation and quantification of cellular mitochondrial morphology and content 

      Tronstad, Karl Johan; Nooteboom, Marco; Hodneland, Linn I.; Nikolaisen, Julie; Sokolewicz, Maciek; Grefte, Sander; Pettersen, Ina Katrine Nitschke; Dyrstad, Sissel Elisabeth; Hoel, Fredrik; Willems, Peter H.G.M.; Koopman, Werner J.H. (Peer reviewed; Journal article, 2014)
      Mitochondria play a key role in signal transduction, redox homeostasis and cell survival, which extends far beyond their classical functioning in ATP production and energy metabolism. In living cells, mitochondrial content ...
    • Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways 

      Æsøy, Reidun; Gradin, Katarina; Åsrud, Kathrine Sivertsen; Høivik, Erling Andre; Ruas, Jorge L.; Poellinger, Lorenz; Bakke, Marit (Peer reviewed; Journal article, 2014-03-11)
      Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear. ...
    • Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins 

      Ghorbani, Sadaf; Fossbakk, Agnete; Jorge Finnigan, Ana; Flydal, Marte Innselset; Haavik, Jan; Kleppe, Rune (Peer reviewed; Journal article, 2016-05)
      Tyrosine hydroxylase (TH) is regulated by members of the 14-3-3 protein family. However, knowledge about the variation between 14-3-3 proteins in their regulation of TH is still limited. We examined the binding, effects ...
    • Regulatory Peptides from Chromogranin A and Secretogranin II 

      Helle, Karen Blaauw (Peer reviewed; Journal article, 2010)
      This commentary is focusing on novel aspects on the secreted CgA- and SgII-derived peptides, vasostatin-I (bovine and human CgA1–76, VS-I), WE-14 (CgA316–329), catestatin (bovine CgA344–366, human CgA352–372, Cts) and the ...
    • Regulatory post-translational modifications and protein-protein interactions involved in function and proteostasis of aromatic amino acid hydroxylases 

      K C, Kunwar Jung (Doctoral thesis, 2021-09-16)
      The non-heme iron and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) dependent aromatic amino acid hydroxylases (AAAHs) family of enzymes include phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), and tryptophan ...
    • The Regulatory Subunit of PKA-I Remains Partially Structured and Undergoes b-Aggregation upon Thermal Denaturation 

      Dao, Khanh K.; Pey, Angel; Gjerde, Anja Underhaug; Teigen, Knut; Byeon, In-Ja L.; Døskeland, Stein Ove; Gronenborn, Angela M.; Martinez, Aurora (Peer reviewed; Journal article, 2011-03-04)
      Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic ...
    • Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype 

      Bayer, Monika Lucia; Schjerling, Peter; Herchenhan, Andreas; Zeltz, Cedric; Heinemeier, Katja Maria; Christensen, Lise; Krogsgaard, Michael; Gullberg, Donald; Kjær, Michael (Peer reviewed; Journal article, 2014-01-21)
      Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. We investigated ...

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