Browsing Department of Biomedicine by Title
Now showing items 21-40 of 530
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Annexin A2 binds the internal ribosomal entry site of c-myc mRNA and regulates its translation
(Journal article; Peer reviewed, 2021)The expression and localization of the oncoprotein c-Myc is highly regulated at the level of transcription, mRNA transport, translation, as well as stability of the protein. We previously showed that Annexin A2 (AnxA2) ... -
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin
(Peer reviewed; Journal article, 2017-01)The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable ... -
Antibodies raised against aldehyde-fixed antigens improve sensitivity for postembedding electron microscopy
(Peer reviewed; Journal article, 2019)Background: Antibodies are one of the most important tools in biological research. High specificity and sensitivity of antibodies are crucial to obtain reliable results. Tissue fixed with glutaraldehyde (GA) is commonly ... -
Apicomplexan actin polymerization depends on nucleation
(Peer reviewed; Journal article, 2017-09-22)Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ... -
The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity
(Peer reviewed; Journal article, 2010-08-06)Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute ... -
Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease. Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice
(Master thesis, 2017)The overarching goal of this project was to help elucidate how some of the molecular mechanisms behind memory and learning differ between healthy brains and those with neurodegenerative diseases, specifically by studying ... -
Arc interacts with the integral endoplasmic reticulum protein, calnexin
(Peer reviewed; Journal article, 2017-09-20)Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ... -
Arc is a flexible modular protein capable of reversible self-oligomerization
(Peer reviewed; Journal article, 2015)The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ... -
The Arc of synaptic memory
(Peer reviewed; Journal article, 2010)The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ... -
Arc protein-protein interactions in long-term potentiation in the rat dentate gyrus in vivo
(Master thesis, 2014-06-02)Synaptic plasticity is the ability of neuronal synapses to change in strength over time, and is considered to be a foundation for learning and memory. Long-term potentiation (LTP) is a widely studied form of synaptic ... -
Assessment of Image Quality of a PET/CT scanner for a Standarized Image situation Using a NEMA Body Phantom. “The impact of Different Image Reconstruction Parameters on Image quality”
(Master thesis, 2013-09-01)Radiologists and medical practitioners are working daily with images from integrated Positron Emission Tomography/ Computed Tomography (PET/CT) scanners in order to detect potentially lethal diseases. It is thus very ... -
Association between the number of CAG repeats in polymerase gamma and Parkinson disease in the Norwegian population
(Master thesis, 2012-06-01)Parkinson disease (PD) is a common neurodegenerative movement disorder that increases in prevalence with age. It is characterized clinically by resting tremor, rigidity, bradykinesia, and failing balance, and is due to the ... -
Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study
(Peer reviewed; Journal article, 2018-05)Several studies have demonstrated associations between neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD), and the immune system, including autoimmune diseases. Since ADHD and many autoimmune ... -
Atomic view into plasmodium actin polymerization, ATP hydrolysis, and fragmentation
(Peer reviewed; Journal article, 2019)Plasmodium actins form very short filaments and have a noncanonical link between ATP hydrolysis and polymerization. Long filaments are detrimental to the parasites, but the structural factors constraining Plasmodium ... -
Attention Network Test in adults with ADHD - the impact of affective fluctuations
(Peer reviewed; Journal article, 2011-07-27)Background: The Attention Network Test (ANT) generates measures of different aspects of attention/executive function. In the present study we investigated whether adults with ADHD performed different from controls on ... -
Attention-deficit/hyperactivity disorder and smoking habits in pregnant women
(Journal article; Peer reviewed, 2020)Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with an increased risk of tobacco smoking, and more difficulties with smoking cessation compared to non-ADHD individuals. Women with ADHD may ... -
Attention-Deficit/Hyperactivity Disorder in adults. Clinical characteristics and pre- and perinatal risk factors
(Doctoral thesis, 2011-01-28)Attention-deficit/hyperactivity disorder (ADHD) is currently a prevalent diagnosis in child psychiatry, typically affecting 2-5 % of school-aged children world-wide. The recent and increasing awareness that ADHD may persist ... -
Attention-deficit/hyperactivity disorder symptoms and dietary habits in adulthood: A large population-based twin study in Sweden
(Journal article; Peer reviewed, 2020)Associations between adult attention-deficit/hyperactivity disorder (ADHD) symptoms and dietary habits have not been well established and the underlying mechanisms remain unclear. We explored these associations using a ... -
Attention-deficit/hyperactivity disorder; sex differences in psychiatric comorbidity and transgenerational recurrence risks : A population-based study using Norwegian registry data
(Doctoral thesis, 2020-02-07)Background: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous, multifactorial and life-spanning neurodevelopmental disorder for which the underlying mechanisms and causes are not fully understood. Psychiatric ... -
Autoimmune Addison's Disease and DNA Methylation. Identification of Differentially Methylated Regions and Development of Methylation Specific PCR for Selected Genes
(Master thesis, 2012-07-01)Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease (AID) that is characterized by autoreactivity towards the adrenal cortex, leading to insufficient production of steroid hormones and death ...