Blar i Department of Biomedicine på utgivelsesdato
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New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia
(Doctoral thesis, 2007-12-18)Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogenous leukemia (AML). Even though the mechanism of action of anthracyclines has been extensively studied over the years, ... -
Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis
(Doctoral thesis, 2008-02-15)NAD and NADP, both major carriers of cellular reducing equivalents, are of vital importance in diverse metabolic and signaling processes. Efficient maintenance and regulation of the reduction-oxidation status is therefore ... -
Enhanced gene expression from retroviral vectors
(Peer reviewed; Journal article, 2008-02-25)Background: Retroviruses are widely used to transfer genes to mammalian cells efficiently and stably. However, genetic elements required for high-level gene expression are incompatible with standard systems. The retroviral ... -
Phospholipase D in human blood platelets
(Doctoral thesis, 2008-05-30)We have studied phospholipase D (PLD) in human blood platelets. This enzyme hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLDs function in cells. ... -
Intensity-modulated radiotherapy of pelvic lymph nodes in locally advanced prostate cancer: planning procedures and early experiences
(Peer reviewed; Journal article, 2008-07-15) -
Influence of organ motion on conformal vs. intensity-modulated pelvic radiotherapy for prostate cancer
(Peer reviewed; Journal article, 2008-08-01) -
Evolution of structure and function in Phenylalanine Hydroxylase. With the regulatory properties in sight
(Doctoral thesis, 2008-11-07)In the post-genomic era, an idea of how similar the genomes of different species actually are is on the horizon. Less than 10 years ago, the human genome was estimated to encode 100000 genes. That was an overestimation, ... -
Biomedical Image Processing in the Study of Living Cells
(Doctoral thesis, 2008-12-09) -
A randomized double blind comparison of short-term duodenally administrated whale and seal blubber oils in patients with inflammatory bowel disease and joint pain
(Peer reviewed; Journal article, 2009)Compared with soy oil, 10 days treatment with seal oil (SO), 10 mL×3 daily, self-administrated through a nasoduodenal feeding tube, relieves joint pain in patients with inflammatory bowel disease (IBD). This randomized, ... -
Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in non-obese diabetic mice
(Peer reviewed; Journal article, 2009-02-06)Introduction Decreased vascular responses to salivary gland stimulation are observed in Sjögren's syndrome patients. We investigate whether impaired vascular responses to parasympathetic stimulation and muscarinic receptor ... -
The Heart and a Fibrotic Interstitium
(Master thesis, 2009-05-29)Several acute and chronic diseases disposes for myocardial oedema and fibrosis, leading to impaired cardiac function, presumably as a result of an increased chamber stiffness. Mechanisms and adverse effects of both oedema ... -
Design of tumour-specific immunotherapies using dendritic cells – analyses of IL15-DC
(Master thesis, 2009-05-31)Immunotherapy of malignancies aims at activating the patient’s own immune system to fight the tumour affecting the patient. Even though the use of dendritic cells (DC) has shown promising results, the DC vaccination strategy ... -
Characterisation of Immunoglobulin--IgG Responses During Combination Therapy of Chronic Hepatits-C Virus Infection
(Master thesis, 2009-06-02)Current recommended treatment of chronic hepatitis C is the combination of peg interferon and ribavirin. Ribavirin has shown that it poses both direct and indirect action mechanisms against several DNA and RNA viruses. ... -
Dendritic cells in Sjögren's syndrome-functional analyses
(Master thesis, 2009-06-02)Sjögren's syndrome (SS) is an autoimmune disease of unknown etiology. It is characterized by chronic inflammation of the exocrine glands which leads to dryness of the mouth and eyes. Dendritic cells (DC) are the most potent ... -
Design of tumor-specific immunotherapies using dendritic cells - effect of bromelain on dendritic cell maturation
(Master thesis, 2009-06-02)Immunotherapy using dendritic cells (DC) has shown promising results in clinical trials, but few relevant successes are recorded. Therefore, the choice of an appropriate DC population is critical for the outcome of this ... -
An electrophysiological study in freely exploring rats - Place cell properties and place field stability in the absence or presence of reward as a motivational factor.
(Master thesis, 2009-06-02)The activity of pyramidal cells in the hippocampus can be spatially modulated. Numerous studies have been performed examining their properties, like what influences the position of their firing fields or what effect changes ... -
Studies of α11β1 integrin in the mouse and human periodontal ligament
(Doctoral thesis, 2009-06-12) -
Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
(Peer reviewed; Journal article, 2009-07-28)Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-be ... -
Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
(Peer reviewed; Journal article, 2009-08)Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ... -
New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines
(Master thesis, 2009-08-02)Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ...