Blar i Department of Biomedicine på forfatter "Alvira, Sara"
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Arc is a flexible modular protein capable of reversible self-oligomerization
Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Peer reviewed; Journal article, 2015)The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ... -
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
Bueno-Carrasco, María Teresa; Cuellar, Jorge; Flydal, Marte Innselset; Santiago, Cesar; Kråkenes, Trond-André; Kleppe, Rune; Jose R, Lopez-Blanco; Marcilla, Miguel; Teigen, Knut; Alvira, Sara; Chacón, Pablo; Martinez, Aurora; Valpuesta, José M (Journal article; Peer reviewed, 2022)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Inhibition by catecholamines and ...