• In silico identification and experimental validation of hits active against KPC-2 β-lactamase 

      Klein, Raphael; Linciano, Pasquale; Celenza, Guiseppe; Bellio, Pierangelo; Papaioannou, Sofia; Blazques, Jesus; Cendron, Laura; Brenk, Ruth; Tondi, Donatella (Peer reviewed; Journal article, 2018-11-29)
      Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, ...
    • Targeting the Class A Carbapenemase GES-5 via Virtual Screening 

      Klein, Raphael; Cendron, Laura; Montanari, Maria; Bellio, Pierangelo; Celenza, Giuseppe; Maso, Lorenzo; Tondi, Donatella; Brenk, Ruth (Journal article; Peer reviewed, 2020)
      The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A ...