• Antidepressant drugs act by directly binding to TRKB neurotrophin receptors 

      Casarotto, Plinio C.; Girych, Mykhailo; Fred, Senem M.; Kovaleva, Vera; Moliner, Rafael; Enkavi, Giray; Biojone, Caroline; Cannarozzo, Cecilia; Sahu, Madhusmita Pryiadrashini; Kaurinkoski, Katja; Brunello, Cecilia A.; Steinzeig, Anna; Winkel, Frederike; Patil, Sudarshan; Vestring, Stefan; Serchov, Tsvetan; Diniz, Cassiano R.A.F.; Laukkanen, Liina; Cardon, Iseline; Antila, Hanna; Rog, Tomasz; Piepponen, Timo Petteri; Bramham, Clive Raymond Evjen; Normann, Claus; Lauri, Sari E.; Saarma, Mart; Vattulainen, Ilpo; Castrén, Eero (Journal article; Peer reviewed, 2021)
      It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived ...
    • Arc interacts with the integral endoplasmic reticulum protein, calnexin 

      Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Nair Raveendran, Rajeevkumar; Bramham, Clive R. (Peer reviewed; Journal article, 2017-09-20)
      Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ...
    • CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons 

      Esvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex; Patil, Sudarshan; Bramham, Clive R.; Timmusk, Tõnis (Peer reviewed; Journal article, 2020)
      BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming ...
    • Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo 

      Nair Raveendran, Rajeevkumar; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R. (Peer reviewed; Journal article, 2017-05-10)
      Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are ...
    • Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity 

      Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida; Patil, Sudarshan; Kaczorowski, Dominik C.; Bramham, Clive R.; Dinger, Marcel E.; Wibrand, Karin (Peer reviewed; Journal article, 2015-10-01)
      Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the ...
    • The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders 

      Szigetvari, Peter Daniel; Patil, Sudarshan; Birkeland, Even; Kleppe, Rune; Haavik, Jan (Journal article; Peer reviewed, 2023)
      Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, resulting in phenylalanine accumulation and impaired tyrosine production. In Tyrosinemia ...
    • The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA 

      Grindheim, Ann Kari; Patil, Sudarshan; Nebigil, Canan G.; Désaubry, Laurent; Vedeler, Anni (Journal article; Peer reviewed, 2023-05-12)
      Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding ...
    • The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons 

      Leal, Graciano; Comprido, Diogo; de Luca, Pasqualino; Morais, Eduardo; Rodrigues, Luís; Mele, Miranda; Santos, Ana R.; Costa, Rui O.; Pinto, Maria Joana; Patil, Sudarshan; Berentsen, Birgitte; Afonso, Pedro; Carreto, Laura; Li, Ka Wan; Pinheiro, Paulo; Almeida, Ramiro D.; Santos, Manuel A. S.; Bramham, Clive R.; Duarte, Carlos B. (Peer reviewed; Journal article, 2017-11)
      Brain-derived neurotrophic factor (BDNF) is an important mediator of long-term synaptic potentiation (LTP) in the hippocampus. The local effects of BDNF depend on the activation of translation activity, which requires the ...
    • Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment 

      Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)
      The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ...