• Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway 

      Rahman, Mohummad Aminur; Engelsen, Agnete; Sarowar, Shahin; Bindesbøll, Christian; Birkeland, Even; Goplen, Dorota; Lotsberg, Maria Lie; Knappskog, Stian; Simonsen, Anne Gjøen; Enger, Martha (Journal article; Peer reviewed, 2022)
      Introduction: Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation. ...
    • Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival 

      Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-08-15)
      Background Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O6-methyl guanine DNA methyltransferase (MGMT) that is often characterised by unmethylated promoter. Here, ...
    • COVID-19 and the environment: A critical review and research agenda 

      Shakil, Mohammad Hassan; Munim, Ziaul Haque; Tasnia, Mashiyat; Sarowar, Shahin (Journal article; Peer reviewed, 2020)
      The current Coronavirus infection (COVID-19) outbreak has had a substantial impact on many aspects of general life. Although a number of studies have been published on the topic already, there has not been a critical review ...
    • Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients 

      Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya (Peer reviewed; Journal article, 2017)
      Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. However, their presence in GBM tissue is still under debate, and evidence of their impact on functional ...
    • The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis 

      Sarowar, Shahin; Cirillo, Davide; Játiva, Pablo; Nilsen, Mette Hartmark; Otragane, Sarah-Muheha Anni; Heggdal, Jan Ingemann; Selheim, Frode; Ceña, Valentín; Bjørsvik, Hans-René; Enger, Per Øyvind (Journal article; Peer reviewed, 2022)
      Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ...