Blar i Department of Biomedicine på forfatter "Underhaug, Jarl"
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Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
Urbaneja, María A.; Skjærven, Lars; Aubi Catevilla, Oscar; Underhaug, Jarl; López, David J.; Arregi, Igor; Alonso-Mariño, Marián; Cuevas, Andoni; Rodríguez, José A.; Martinez, Aurora; Bañuelos, Sonia (Peer reviewed; Journal article, 2017-10-24)Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ... -
An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
Espeland, Ludvik Olai; Georgiou, Charis; Klein, Raphael; Bhukya, Hemalatha; Haug, Bengt Erik; Underhaug, Jarl; Mainkar, Prathama S.; Brenk, Ruth (Journal article; Peer reviewed, 2021)FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from ... -
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
Dublang, Leire; Underhaug, Jarl; Flydal, Marte Innselset; Velasco-Carneros, Lorea; Maréchal, Jean-Didier; Moro, Fernando; Boyano, Maria Dolores; Martinez, Aurora; Muga, Arturo (Journal article; Peer reviewed, 2021)Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ... -
The Peripheral Binding of 14-3-3γ to Membranes Involves Isoform-Specific Histidine Residues
Bustad, Helene J.; Skjærven, Lars; Ying, Ming; Halskau, Øyvind; Baumann, Anne; Rodriguez-Larrea, David; Costas, Miguel; Underhaug, Jarl; Sanchez-Ruiz, Jose M.; Martinez, Aurora (Peer reviewed; Journal article, 2012-11-26)Mammalian 14-3-3 protein scaffolds include seven conserved isoforms that bind numerous phosphorylated protein partners and regulate many cellular processes. Some 14-3-3-isoforms, notably γ, have elevated affinity for ... -
A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria
Bustad, Helene J.; Toska, Karen; Schmitt, Caroline; Vorland, Marta; Skjærven, Lars; Kallio, Juha Pekka; Simonin, Sylvie; Lettéron, Philippe; Underhaug, Jarl; Sandberg, Sverre; Martinez, Aurora (Peer reviewed; Journal article, 2019-12-03)Mutations in hydroxymethylbilane synthase (HMBS) cause acute intermittent porphyria (AIP), an autosomal dominant disease where typically only one HMBS allele is mutated. In AIP, the accumulation of porphyrin precursors ...