Blar i Department of Biomedicine på tidsskrift "Cell reports"

Viser treff 1-8 av 8

    • Activation-induced chromatin reorganization in neurons depends on HDAC1 activity 

      Grabowska, Agnieszka; Sas-Nowosielska, Hanna; Wojtas, Bartosz; Holm-Kaczmarek, Dagmara; Januszewicz, Elzbieta; Yushkevich, Yana; Czaban, Iwona; Trzaskoma, Pawel; Krawczyk, Katarzyna; Gielniewski, Bartlomiej; Martin-Gonzalez, Ana; Filipkowski, Robert Kuba; Olszynski, Krzysztof Hubert; Bernas, Tytus; Szczepankiewicz, Andrzej Antoni; Sliwinska, Malgorzata Alicja; Kanhema, Tambudzai; Bramham, Clive Raymond Evjen; Bokota, Grzegorz; Plewczynski, Dariusz; Wilczynski, Grzegorz Marek; Magalska, Adriana (Journal article; Peer reviewed, 2022)
      Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that ...

    • Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors 

      Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad; Miyano, Masaru; Lin, ChunHan; Jokela, Tiina; Kumar, Sanjay; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. (Peer reviewed; Journal article, 2014-06-26)
      Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to ...

    • Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin 

      Snaidero, Nicolas; Velte, Caroline; Myllykoski, Matti; Raasakka, Arne; Ignatev, Alexander; Werner, Hauke B.; Erwig, Michelle S.; Möbius, Wiebke; Kursula, Petri; Nave, Klaus-Armin; Simons, Mikael (Peer reviewed; Journal article, 2017-01)
      The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable ...

    • High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia 

      Pelissier, Fanny; Schapiro, Denis; Chang, Hang; Borowsky, Alexander D.; Lee, Jonathan K.; Parvin, Bahram; Stampfer, Martha R.; LaBarge, Mark A.; Bodenmiller, Bernd; Lorens, James B. (Peer reviewed; Journal article, 2018-04)
      Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished ...

    • The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1 

      Walter, Jonas; Bolognin, Silvia; Poovathingal, Suresh K.; Magni, Stefano; Gérard, Deborah; Antony, Paul M. A.; Nickels, Sarah L.; Salamanca, Luis; Berger, Emanuel; Smits, Lisa M.; Grzyb, Kamil; Perfeito, Rita; Hoel, Fredrik; Qing, Xiaobing; Ohnmacht, Jochen; Bertacchi, Michele; Jarazo, Javier; Ignac, Tomasz; Monzel, Anna S.; Gonzalez-Cano, Laura; Krüger, Rejko; Sauter, Thomas; Studer, Michèle; Pereira de Almeida, Luis; Tronstad, Karl Johan; Sinkkonen, Lasse; Skupin, Alexander; Schwamborn, Jens C. (Journal article; Peer reviewed, 2021)
      Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in ...

    • Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity 

      Kouloulia, Stella; Hallin, Erik Ingmar; Simbriger, Konstanze; Amorim, Ines S; Lach, Gilliard; Amvrosiadis, Theoklitos; Chalkiadaki, Kleanthi; Kampaite, Agniete; Truong, Vinh Tai; Hooshmandi, Mehdi; Jafarnejad, Seyed Mehdi; Skehel, Paul; Kursula, Petri; Khoutorsky, Arkady; Gkogkas, Christos (Peer reviewed; Journal article, 2019)
      The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central ...

    • Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s 

      Wagner, Marek; Ealey, Kafi N; Tetsu, Hiroe; Kiniwa, Tsuyoshi; Motomura, Yasutaka; Moro, Kazuyo; Koyasu, Shigeo (Journal article; Peer reviewed, 2020)
      Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune ...

    • Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK 

      Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Peer reviewed; Journal article, 2014-11-20)
      BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...