• Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy 

      Klein, Eliane; Hau, Ann-Christin; Oudin, Anaïs; Golebiewska, Anna; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-12-08)
      Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall survival is roughly over a year. New therapeutic ...
    • LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM 

      Zheng, Jingfang; Su, Zhiying; Kong, Yang; Lin, Qingping; Liu, Hongli; Wang, Yanlong; Wang, Jian (Journal article; Peer reviewed, 2020)
      Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent ...
    • The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma 

      Kong, Yang; Feng, Zichao; Chen, Anjing; Qi, Qichao; Han, Mingzhi; Wang, Shuai; Zhang, Yulin; Zhang, Xin; Yang, Ning; Wang, Jiwei; Huang, Bin; Zhang, Qing; Xiang, Guo; Li, Wenjie; Zhang, Di; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019-09-27)
      Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ...