Browsing Department of Biomedicine by Journals "Frontiers in Oncology"

Now showing items 1-7 of 7

    • Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy 

      Klein, Eliane; Hau, Ann-Christin; Oudin, Anaïs; Golebiewska, Anna; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-12-08)
      Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall survival is roughly over a year. New therapeutic ...

    • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

      Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Peer reviewed, 2023)
      Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity ...

    • LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM 

      Zheng, Jingfang; Su, Zhiying; Kong, Yang; Lin, Qingping; Liu, Hongli; Wang, Yanlong; Wang, Jian (Journal article; Peer reviewed, 2020)
      Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent ...

    • The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma 

      Kong, Yang; Feng, Zichao; Chen, Anjing; Qi, Qichao; Han, Mingzhi; Wang, Shuai; Zhang, Yulin; Zhang, Xin; Yang, Ning; Wang, Jiwei; Huang, Bin; Zhang, Qing; Xiang, Guo; Li, Wenjie; Zhang, Di; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019-09-27)
      Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ...

    • PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas 

      Ohba, Shigeo; Tang, Yongjian; Johannessen, Tor-Christian Aase; Mukherjee, Joydeep (Journal article; Peer reviewed, 2022)
      PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, ...

    • The styryl benzoic acid derivative DC10 potentiates radiotherapy by targeting the xCT-glutathione axis 

      Sarowar, Shahin; Cirillo, Davide; Játiva, Pablo; Nilsen, Mette Hartmark; Otragane, Sarah-Muheha Anni; Heggdal, Jan Ingemann; Selheim, Frode; Ceña, Valentín; Bjørsvik, Hans-René; Enger, Per Øyvind (Journal article; Peer reviewed, 2022)
      Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to ...

    • Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis 

      Martínez-Nieto, Guillermo A.; Teppo, Hanna-Riikka; Petrelius, Noora; Izzi, Valerio; Devarajan, Raman; Petäistö, Tiina; Liu, Hengshuo; Kim, Kris S.; Karppinen, Sanna-Maria; Ruotsalainen, Heli; Koivunen, Jarkko; Mäki, Joni M.; Walker, Gilbert C.; Pihlajaniemi, Taina; Gullberg, Elon Donald; Heljasvaara, Ritva Leena (Journal article; Peer reviewed, 2022)
      Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated ...