Browsing Department of Biomedicine by Journals "Future Medicinal Chemistry"
Now showing items 1-2 of 2
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Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis
(Journal article; Peer reviewed, 2020)Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Selective TPH1 inhibitors may be useful for treating disorders related to serotonin dysregulation. Results & methodology: Screening ... -
Synthetic corticosteroids as tryptophan hydroxylase stabilizers
(Journal article; Peer reviewed, 2021)Background: Clinically, corticosteroids are used mainly for their immune-modulatory properties but are also known to influence mood. Despite evidence of a role in regulating tryptophan hydroxylases (TPH), key enzymes in ...