Browsing Department of Biomedicine by Journals "Neuro-Oncology"

Now showing items 1-4 of 4

    • Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma 

      Yabo, Yahaya A.; Niclou, Simone Pierrette; Golebiewska, Anna (Journal article; Peer reviewed, 2022)
      Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells display prominent intrinsic plasticity and ...

    • Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis 

      Roesler, Jenny; Spitzer, Daniel; Jia, Xiaoxiong; Aasen, Synnøve Nymark; Sommer, Kathleen; Roller, Bastian; Olshausen, Niels; Hebach, Nils R.; Albinger, Nawid; Ullrich, Evelyn; Zhu, Ling; Wang, Fan; MacAs, Jadranka; Forster, Marie-Therese; Steinbach, Joachim P.; Sevenich, Lisa; Devraj, Kavi; Thorsen, Frits; Karreman, Matthia A.; Plate, Karl H.; Reiss, Yvonne; Harter, Patrick N. (Journal article; Peer reviewed, 2024)
      Background Brain metastases (BM) constitute an increasing challenge in oncology due to their impact on neurological function, limited treatment options, and poor prognosis. BM occurs through extravasation of circulating ...

    • Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma 

      Hossain, Jubayer; Latif, Md Abdul; Ystaas, Lars Andreas Rømo; Ninzima, Sandra; Riecken, Kristoffer; Muller, Arnaud; Azuaje, Fransisco; Vareecal Joseph, Justin; Talasila, Krishna Mukharji; Ghimire, Jiwan; Fehse, Boris; Bjerkvig, Rolf; Miletic, Hrvoje (Peer reviewed; Journal article, 2019)
      Background: Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when ...

    • Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors 

      Knudsen, Arnon Møldrup; Halle, Bo; Cédile, Oriane; Burton, Mark; Baun, Christina; Thisgaard, Helge; Anand, Atul; Hubert, Christopher; Thomassen, Mads; Michaelsen, Signe Regner; Olsen, Birgitte Brinkmann; Dahlrot, Rikke Hedegaard; Bjerkvig, Rolf; Lathia, Justin Durla; Kristensen, Bjarne Winther (Journal article; Peer reviewed, 2022)
      Background Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its ...