Blar i Department of Biomedicine på tidsskrift "eLIFE"
Viser treff 1-2 av 2
-
Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
(Peer reviewed; Journal article, 2019-05-20)Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like ... -
Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication
(Journal article; Peer reviewed, 2021)Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation ...