• Breathlessness across generations: results from the RHINESSA generation study 

      Ekström, Magnus; Johannessen, Ane; Abramson, Michael J.; Benediktsdóttir, Bryndís; Franklin, Karl A.; Gislason, Thorarinn; Real, Francisco Gomez; Holm, Mathias; Janson, Christer; Jogi, Rain; Lowe, Adrian J.; Malinovschi, Andrei; Martínez-Moratalla, Jesús; Oudin, Anna; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Svanes, Cecilie (Journal article; Peer reviewed, 2022)
      Background Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated ...
    • Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort 

      Svanes, Cecilie; Johannessen, Ane; Bertelsen, Randi Jacobsen; Dharmage, Shyamali; Benediktsdottir, Bryndis; Bråbäck, Lennart; Gislason, Thorarinn; Holm, Mathias; Jögi, Oskar; Lodge, Caroline J; Malinovschi, Andrei; Martinez-Moratalla, Jesus; Oudin, Anna; Sánchez-Ramos, José Luis; Timm, Signe; Janson, Christer; Real, Francisco Gomez; Schlünssen, Vivi (Journal article; Peer reviewed, 2022)
      Purpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, ...
    • Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization 

      Krantz, Christina; Accordini, Simone; Alving, Kjell; Corsico, Angelo G.; Demoly, Pascal; Ferreira, Diogenes S.; Forsberg, Bertil; Garcia-Aymerich, Judith; Gislason, Thorarinn; Heinrich, Joachim; Jõgi, Rain; Johannessen, Ane; Leynaert, Bénédicte; Marcon, Alessandro; Martínez-Moratalla Rovira, Jesús; Nerpin, Elisabet; Nowak, Dennis; Olin, Anna-Carin; Olivieri, Mario; Pereira-Vega, Antonio; Raherison-Semjen, Chantal; Real, Francisco Gomez; Sigsgaard, Torben; Squillacioti, Giulia; Janson, Christer; Malinovschi, Andrei (Journal article; Peer reviewed, 2022)
      Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitization as a major determinant. Objective: We aimed to ...
    • The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome? 

      López Cervantes, Juan Pablo; Lønnebotn, Marianne; Jögi, Nils Oskar; Calciano, Lucia; Kuiper, Ingrid Nordeide; Darby, Matthew G; Dharmage, Shyamali Chandrika; Real, Francisco Gomez; Hammer, Barbara; Bertelsen, Randi Jacobsen; Johannessen, Ane; Würtz, Anne Mette Lund; Knudsen, Gerd Toril Mørkve; Koplin, Jennifer; Pape, Kathrine; Skulstad, Svein Magne; Timm, Signe; Tjalvin, Gro; Krauss-Etschmann, Susanne; Accordini, Simone; Schlünssen, Vivi; Kirkeleit, Jorunn; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering ...
    • Exposures during the prepuberty period and future offspring's health: evidence from human cohort studies 

      Svanes, Cecilie; Bertelsen, Randi Jacobsen; Accordini, Simone; Holloway, John W.; Juliusson, Pétur Benedikt; Boateng, Eistine; Krauss-Etchmann, Susanne; Schlünssen, Vivi; Real, Francisco Gomez; Skulstad, Svein Magne (Journal article; Peer reviewed, 2021)
      Emerging evidence suggests that exposures in prepuberty, particularly in fathers-to-be, may impact the phenotype of future offspring. Analyses of the RHINESSA cohort find that offspring of father’s exposed to tobacco smoking ...
    • Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma 

      Tjalvin, Gro; Svanes, Øistein; Igland, Jannicke; Bertelsen, Randi Jacobsen; Benediktsdóttir, Bryndís; Dharmage, Shyamali; Forsberg, Bertil; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Johannessen, Ane; Malinovschi, Andrei; Pape, Kathrine; Real, Francisco Gomez; Sigsgaard, Torben; Torén, Kjell; Vindenes, Hilde Kristin; Zock, Jan-Paul; Schlünssen, Vivi; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Background Emerging research suggests health effects in offspring after parental chemical exposures before conception. Many future mothers are exposed to potent chemicals at work, but potential offspring health effects ...
    • Parental Prepuberty Overweight and Offspring Lung Function 

      Lønnebotn, Marianne; Calciano, Lucia; Johannessen, Ane; Jarvis, Deborah L; Abramson, Michael J.; Benediktsdottir, Bryndis; Bråbäck, Lennart; Franklin, Karl A.; Godoy, Raúl; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Kirkeleit, Jorunn; Malinovschi, Andrei; Pereira-Vega, Antonio; Schlunssen, Vivi; Dharmage, Shyamali C.; Accordini, Simone; Real, Francisco Gomez; Svanes, Cecilie (Journal article; Peer reviewed, 2022)
      In a recent study we found that fathers’ but not mothers’ onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring’s adult lung function, a key marker of general and ...
    • Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach 

      Accordini, Simone; Calciano, Lucia; Johannessen, Ane; Benediktsdóttir, Bryndis; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali C.; Forsberg, Bertil; Real, Francisco Gomez; Holloway, John W.; Holm, Mathias; Janson, Christer; Jõgi, Nils O.; Jõgi, Rain; Malinovschi, Andrei; Marcon, Alessandro; Martínez-Moratalla Rovira, Jesús; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Torén, Kjell; Jarvis, Deborah; Svanes, Cecilie (Journal article; Peer reviewed, 2021)
      Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very ...