• Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder - a longitudinal sibling control study 

      Gustavson, Kristin; Ystrøm, Eivind; Ask, Helga; Torvik, Fartein Ask; Hornig, Mady; Susser, Ezra; Lipkin, Ian; Lupattelli, Angela; Stoltenberg, Camilla; Magnus, Per Minor; Mjaaland, Siri; Askeland, Ragna Bugge; Walle, Kjersti Mæhlum; Bresnahan, Michaeline; Nordeng, Hedvig Marie Egeland; Reichborn-Kjennerud, Ted (Journal article, 2021)
      Background: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding ...
    • Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry 

      Bohlin, Jon; Page, Christian Magnus; Lee, Yunsung; Pettersson, John H.-O.; Jugessur, Astanand; Magnus, Per Minor; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2022)
      Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina ...
    • Associations between epigenetic age acceleration and infertility 

      Lee, Yunsung; Bohlin, Jon; Page, Christian Magnus; Nustad, Haakon E.; Harris, Jennifer Ruth; Magnus, Per Minor; Magnus, Per; Jugessur, Astanand; Magnus, Maria Christine; Håberg, Siri Eldevik; Hanevik, Hans Ivar (Journal article; Peer reviewed, 2022)
      Study question: Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration? Summary answer: The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed ...
    • DNA methylation in newborns conceived by assisted reproductive technology 

      Håberg, Siri Eldevik; Page, Christian Magnus; Lee, Yunsung; Nustad, Haakon Egdetveit; Magnus, Maria Christine; Haftorn, Kristine Løkås; Carlsen, Ellen Øen; Denault, William Robert Paul; Bohlin, Jon; Jugessur, Astanand; Magnus, Per Minor; Gjessing, Håkon Kristian; Lyle, Robert (Journal article; Peer reviewed, 2022)
      Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo ...
    • Do Genetic Variants Modify the Effect of Smoking on Risk of Preeclampsia in Pregnancy? 

      Bauer, Anna E.; Avery, Christy L.; Shi, Min; Weinberg, Clarice R.; Olshan, Andrew F.; Harmon, Quaker E.; Luo, Jingchun; Yang, Jenny; Manuck, Tracy; Wu, Michael C.; Klungsøyr, Kari; Trogstad, Lill; Magnus, Per Minor; Engel, Stephanie M. (Journal article; Peer reviewed, 2021)
      Objective: Maternal smoking is associated with as much as a 50% reduced risk of preeclampsia, despite increasing risk of other poor pregnancy outcomes that often co-occur with preeclampsia, such as preterm birth and fetal ...
    • The educational burden of disease: a cohort study 

      Nordmo, Magnus; Kinge, Jonas Minet; Reme, Bjørn-Atle; Flatø, Martin; Suren, Pål; Wörn, Jonathan; Magnus, Per Minor; Stoltenberg, Camilla; Torvik, Fartein Ask (Journal article; Peer reviewed, 2022)
      Background Students with health disorders might be at risk of disengaging from education, which can reinforce socioeconomic inequalities in health. We aimed to evaluate the associations between 176 diseases and injuries ...
    • Effectiveness of mRNA booster vaccination against mild, moderate, and severe COVID-19 caused by the Omicron variant in a large, population-based, Norwegian cohort 

      Laake, Ida; Skodvin, Siri Nærland; Blix, Kristine; Caspersen, Ida Henriette; Gjessing, Håkon K.; Juvet, Lene Kristine; Magnus, Per Minor; Mjaaland, Siri; Robertson, Anna Hayman; Starrfelt, Jostein; Trogstad, Lill; Feiring, Berit (Journal article; Peer reviewed, 2022)
      Background Understanding how booster vaccination can prevent moderate and severe illness without hospitalization is crucial to evaluate the full advantage of mRNA boosters. Methods We followed 85 801 participants (aged ...
    • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 

      Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)
      Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ...
    • An examination of mediation by DNA methylation on birthweight differences induced by assisted reproductive technologies 

      Carlsen, Ellen Øen; Lee, Yunsung; Magnus, Per Minor; Jugessur, Astanand; Page, Christian Magnus; Nustad, Haakon Egdetveit; Håberg, Siri Eldevik; Lie, Rolv Terje; Magnus, Maria Christine (Journal article; Peer reviewed, 2022)
      Background Children born after assisted reproductive technologies (ART) differ in birthweight from those naturally conceived. It has been hypothesized that this might be explained by epigenetic mechanisms. We examined ...
    • Nucleated red blood cells explain most of the association between DNA methylation and gestational age 

      Haftorn, Kristine Løkås; Denault, William Robert Paul; Lee, Yunsung; Page, Christian Magnus; Romanowska, Julia; Lyle, Robert; Næss, Øyvind Erik; Kristjansson, Dana; Magnus, Per Minor; Håberg, Siri Eldevik; Bohlin, Jon; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ...
    • Risk of attention‐deficit hyperactivity disorder in offspring of mothers with infections during pregnancy 

      Walle, Kjersti Mæhlum; Askeland, Ragna Bugge; Gustavson, Kristin; Mjaaland, Siri; Ystrøm, Eivind; Lipkin, W. Ian; Magnus, Per Minor; Stoltenberg, Camilla; Susser, Ezra; Bresnahan, Michaeline; Hornig, Mady; Reichborn-Kjennerud, Ted; Ask, Helga (Journal article; Peer reviewed, 2022)
      Background Maternal infections during pregnancy are common events that have been suggested to be risk factors for Attention-deficit hyperactivity disorder (ADHD) in offspring. Only a few studies have been conducted to ...
    • The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome? 

      Romanowska, Julia; Nustad, Haakon Egdetveit; Page, Christian Magnus; Denault, William Robert Paul; Lee, Yunsung; Magnus, Maria Christine; Haftorn, Kristine Løkås; Gjerdevik, Miriam; Novakovic, Boris; Saffery, Richard; Gjessing, Håkon K.; lyle, robert; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Background Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated ...