Browsing Department of Global Public Health and Primary Care by Author "Page, Christian Magnus"

Now showing items 1-11 of 11

    • Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry 

      Bohlin, Jon; Page, Christian Magnus; Lee, Yunsung; Pettersson, John H.-O.; Jugessur, Astanand; Magnus, Per Minor; Håberg, Siri Eldevik (Journal article; Peer reviewed, 2022)
      Male sex and advanced age are associated with severe symptoms of COVID-19. Sex and age also exhibit substantial associations with genome-wide DNA methylation (DNAm) differences in humans. Using a random sample of Illumina ...

    • Associations between epigenetic age acceleration and infertility 

      Lee, Yunsung; Bohlin, Jon; Page, Christian Magnus; Nustad, Haakon E.; Harris, Jennifer Ruth; Magnus, Per Minor; Magnus, Per; Jugessur, Astanand; Magnus, Maria Christine; Håberg, Siri Eldevik; Hanevik, Hans Ivar (Journal article; Peer reviewed, 2022)
      Study question: Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration? Summary answer: The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed ...

    • Cross-fitted instrument: A blueprint for one-sample Mendelian randomization 

      Denault, William Robert Paul; Bohlin, Jon; Page, Christian Magnus; Burgess, Stephen; Jugessur, Astanand (Journal article; Peer reviewed, 2022-08-29)
      Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the application of a new ...

    • DNA methylation in newborns conceived by assisted reproductive technology 

      Håberg, Siri Eldevik; Page, Christian Magnus; Lee, Yunsung; Nustad, Haakon Egdetveit; Magnus, Maria Christine; Haftorn, Kristine Løkås; Carlsen, Ellen Øen; Denault, William Robert Paul; Bohlin, Jon; Jugessur, Astanand; Magnus, Per Minor; Gjessing, Håkon Kristian; Lyle, Robert (Journal article; Peer reviewed, 2022)
      Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo ...

    • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 

      Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit; Lyle, Robert; Gjessing, Håkon Kristian; Malmberg, Anni; Magnus, Maria Christine; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand; Bohlin, Jon (Journal article; Peer reviewed, 2021)
      Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate ...

    • An examination of mediation by DNA methylation on birthweight differences induced by assisted reproductive technologies 

      Carlsen, Ellen Øen; Lee, Yunsung; Magnus, Per Minor; Jugessur, Astanand; Page, Christian Magnus; Nustad, Haakon Egdetveit; Håberg, Siri Eldevik; Lie, Rolv Terje; Magnus, Maria Christine (Journal article; Peer reviewed, 2022)
      Background Children born after assisted reproductive technologies (ART) differ in birthweight from those naturally conceived. It has been hypothesized that this might be explained by epigenetic mechanisms. We examined ...

    • Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight 

      Küpers, Leanne K.; Monnereau, Claire; Sharp, Gemma C.; Yousefi, Paul; Salas, Lucas A.; Ghantous, Akram; Page, Christian Magnus; Reese, Sarah E.; Wilcox, Allen J.; Czamara, Darina; Starling, Anne P.; Novoloaca, Alexei; Lent, Samantha; Roy, Ritu; Hoyo, Cathrine; Breton, Carrie V.; Allard, Catherine; Just, Allan C.; Bakulski, Kelly M.; Holloway, John W.; Everson, Todd M.; Xu, Cheng-Jian; Huang, Rae-Chi; van der Plaat, Diana A.; Wielscher, Matthias; Merid, Simon Kebede; Ullemar, Vilhelmina; Rezwan, Faisal I.; Lahti, Jari; van Dongen, Jenny; Langie, Sabine A.S.; Richardson, Tom G.; Magnus, Maria Christine; Nohr, Ellen A.; Xu, Zongli; Duijts, Liesbeth; Zhao, Shanshan; Zhang, Weiming; Plusquin, Michelle; DeMeo, Dawn L.; Solomon, Olivia; Heimovaara, Joosje H.; Jima, Dereje D.; Gao, Lu; Bustamante, Mariona; Perron, Patrice; Wright, Robert O.; Hertz-Picciotto, Irva; Zhang, Hongmei; Karagas, Margaret R.; Gehring, Ulrike; Marsit, Carmen J.; Beilin, Lawrence J.; Vonk, Judith M.; Jarvelin, Marjo-Riitta; Bergström, Anna; Örtqvist, Anne K.; Ewart, Susan; Villa, Pia M.; Moore, Sophie E.; Willemsen, Gonneke; Standaert, Arnout R.L.; Håberg, Siri Eldevik; Sørensen, Thorkild I.A.; Taylor, Jack A.; Räikkönen, Katri; Yang, Ivana V.; Kechris, Katerina; Nawrot, Tim S.; Silver, Matt J.; Gong, Yun Yun; Richiardi, Lorenzo; Kogevinas, Manolis; Litonjua, Augusto A.; Eskenazi, Brenda; Huen, Karen; Mbarek, Hamdi; Maguire, Rachel L.; Dwyer, Terence; Vrijheid, Martine; Bouchard, Luigi; Baccarelli, Andrea A.; Croen, Lisa A.; Karmaus, Wilfried; Anderson, Denise; de Vries, Maaike; Sebert, Sylvain; Kere, Juha; Karlsson, Robert; Arshad, Syed Hasan; Hämäläinen, Esa; Routledge, Michael N.; Boomsma, Dorret I.; Feinberg, Andrew P.; Newschaffer, Craig J.; Govarts, Eva; Moisse, Matthieu; Fallin, M. Daniele; Melén, Erik; Prentice, Andrew M.; Kajantie, Eero; Almqvist, Catarina; Oken, Emily; Dabelea, Dana; Boezen, H. Marike; Melton, Philip E.; Wright, Rosalind J.; Koppelman, Gerard H.; Trevisi, Letizia; Hivert, Marie-France; Sunyer, Jordi; Munthe-Kaas, Monica Cheng; Murphy, Susan K.; Corpeleijn, Eva; Wiemels, Joseph L.; Holland, Nina; Herceg, Zdenko; Binder, Elisabeth B.; Davey Smith, George; Jaddoe, Vincent V.W.; Lie, Rolv T.; Nystad, Wenche; London, Stephanie J.; Lawlor, Debbie A.; Relton, Caroline L.; Snieder, Harold; Felix, Janine F. (Peer reviewed; Journal article, 2019-04-23)
      Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in ...

    • Nucleated red blood cells explain most of the association between DNA methylation and gestational age 

      Haftorn, Kristine Løkås; Denault, William Robert Paul; Lee, Yunsung; Page, Christian Magnus; Romanowska, Julia; Lyle, Robert; Næss, Øyvind Erik; Kristjansson, Dana; Magnus, Per Minor; Håberg, Siri Eldevik; Bohlin, Jon; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ...

    • Statistical methods to detect mother-father genetic interaction effects on risk of infertility: A genome-wide approach 

      Skodvin, Siri Nærland; Gjessing, Håkon Kristian; Jugessur, Astanand; Romanowska, Julia; Page, Christian Magnus; Corfield, Elizabeth Claire; Lee, Yunsung; Håberg, Siri Eldevik; Gjerdevik, Miriam (Journal article; Peer reviewed, 2023)
      Infertility is a heterogeneous phenotype, and for many couples, the causes of fertility problems remain unknown. One understudied hypothesis is that allelic interactions between the genotypes of the two parents may influence ...

    • Stroke survival and the impact of geographic proximity to family members: A population-based cohort study 

      Choi, Hye Jung; Leblanc, Marissa Erin; Moger, Tron Anders; Valberg, Morten; Aamodt, Geir; Page, Christian Magnus; Tell, Grethe Seppola; Næss, Øyvind Erik (Journal article; Peer reviewed, 2022)
      Introduction Familial support may be important for post-stroke survival. Objective To determine if geographical proximity between stroke survivors and their family members, i.e having a spouse/partner or distance to ...

    • The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome? 

      Romanowska, Julia; Nustad, Haakon Egdetveit; Page, Christian Magnus; Denault, William Robert Paul; Lee, Yunsung; Magnus, Maria Christine; Haftorn, Kristine Løkås; Gjerdevik, Miriam; Novakovic, Boris; Saffery, Richard; Gjessing, Håkon K.; lyle, robert; Magnus, Per Minor; Håberg, Siri Eldevik; Jugessur, Astanand (Journal article; Peer reviewed, 2023)
      Background Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated ...