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dc.contributor.authorMorken, Nils-Halvdanen_US
dc.contributor.authorTravlos, Gregory S.en_US
dc.contributor.authorWilson, Ralph E.en_US
dc.contributor.authorEggesbø, Merete Åseen_US
dc.contributor.authorLongnecker, Matthew P.en_US
dc.date.accessioned2015-02-23T10:55:54Z
dc.date.available2015-02-23T10:55:54Z
dc.date.issued2014-07-08eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/9421
dc.description.abstractBackground The relationship of maternal glomerular filtration rate (GFR) in pregnancy to fetal size needs to be better characterized as it impacts an ongoing debate about confounding effect of maternal GFR in investigations of important environmental contaminants. We aimed to characterize the size of the association between maternal GFR and infant birth weight. Materials and Methods A sub-cohort of 953 selected women (470 women with and 483 women without preeclampsia) in the Norwegian Mother and Child Cohort (MoBa), recruited during 2003–2007 were analyzed. GFR in the second trimester was estimated based on plasma creatinine. Birth weight was ascertained from the Medical Birth Registry of Norway. Multivariate linear regression was used to evaluate the association between maternal GFR in second trimester (estimated by the Cockroft-Gault [GFR-CG] and the modification of diet in renal disease [GFR-MDRD] formulas) and infant birth weight. Partial correlation coefficients were also calculated. Results Maternal GFR-CG (β: 0.73 g/ml/min, p = 0.04) and GFR-MDRD (β: 0.83 g/ml/min, p = 0.04) were associated with infant birth weight in models adjusted for maternal weight in kilograms, preeclampsia, and gestational age at delivery (days). Partial correlation coefficients for the association between infant birth weight and GFR were 0.07 for both formulas. Although the birth weight-GFR association was stronger among the women with preeclampsia, the difference from women without preeclampsia was not statistically significant. Conclusion These data support an association between GFR during pregnancy and infant birth weight, and indicate that GFR may confound selected epidemiologic associations.en_US
dc.language.isoengeng
dc.publisherPLoSeng
dc.rightsPublic Domaineng
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/eng
dc.titleMaternal glomerular filtration rate in pregnancy and fetal sizeen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-02-23T10:48:31Z
dc.description.versionpublishedVersionen_US
dc.source.articlenumbere101897
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0101897
dc.identifier.cristin1166585
dc.source.journalPLoS ONE
dc.source.409
dc.source.147


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