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dc.contributor.authorNitter, Mathilde Hjelleen_US
dc.contributor.authorNorgård, Benedicte Wentzelen_US
dc.contributor.authorDe Vogel, Stefanen_US
dc.contributor.authorEussen, Simoneen_US
dc.contributor.authorMeyer, Klausen_US
dc.contributor.authorUlvik, Arveen_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorNygård, Ottaren_US
dc.contributor.authorVollset, Stein Emilen_US
dc.contributor.authorBjørge, Toneen_US
dc.contributor.authorTjønneland, Anneen_US
dc.contributor.authorHansen, Louiseen_US
dc.contributor.authorBoutron-Ruault, Marie-Christineen_US
dc.contributor.authorRacine, Antoineen_US
dc.contributor.authorCottet, Vanessaen_US
dc.contributor.authorKaaks, Rudolfen_US
dc.contributor.authorKühn, Tilmanen_US
dc.contributor.authorTrichopoulou, Antoniaen_US
dc.contributor.authorBamia, Christinaen_US
dc.contributor.authorNaska, Andronikien_US
dc.contributor.authorGrioni, Saraen_US
dc.contributor.authorPalli, Domenicoen_US
dc.contributor.authorPanico, Salvatoreen_US
dc.contributor.authorTumino, Rosarioen_US
dc.contributor.authorVineis, Paoloen_US
dc.contributor.authorBueno-de-Mesquita, H. Basen_US
dc.contributor.authorVan Kranen, Henk J.en_US
dc.contributor.authorPeeters, Petra H. M.en_US
dc.contributor.authorWeiderpass, Elisabeteen_US
dc.contributor.authorDorronsoro, Mirenen_US
dc.contributor.authorJakszyn, Paulaen_US
dc.contributor.authorSánchez, María-Joséen_US
dc.contributor.authorArgüelles, Marcial Vicenteen_US
dc.contributor.authorHuerta, José-Mariaen_US
dc.contributor.authorBarricarte, Aurelioen_US
dc.contributor.authorJohansson, Matthiasen_US
dc.contributor.authorLjuslinder, Ingriden_US
dc.contributor.authorKhaw, Kay Teeen_US
dc.contributor.authorWareham, Nicholas J.en_US
dc.contributor.authorFreisling, Heinzen_US
dc.contributor.authorDuarte-Salles, Talitaen_US
dc.contributor.authorStepien, Magdalenaen_US
dc.contributor.authorGunter, Mark J.en_US
dc.contributor.authorRiboli, Élio B.en_US
dc.date.accessioned2015-02-27T11:48:41Z
dc.date.available2015-02-27T11:48:41Z
dc.date.issued2014-08eng
dc.identifier.issn0923-7534
dc.identifier.urihttps://hdl.handle.net/1956/9444
dc.description.abstractBackground Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as alternative methyl group donors when folate status is low. Patients and methods We conducted a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), to investigate plasma concentrations of the methyl donors methionine, choline, betaine (trimethylglycine), and dimethylglycine (DMG) in relation to colorectal cancer (CRC) risk. Our study included 1367 incident CRC cases (965 colon and 402 rectum) and 2323 controls matched by gender, age group, and study center. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for CRC risk were estimated by conditional logistic regression, comparing the fifth to the first quintile of plasma concentrations. Results Overall, methionine (OR: 0.79, 95% CI: 0.63–0.99, P-trend = 0.05), choline (OR: 0.77, 95% CI: 0.60–0.99, P-trend = 0.07), and betaine (OR: 0.85, 95% CI: 0.66–1.09, P-trend = 0.06) concentrations were inversely associated with CRC risk of borderline significance. In participants with folate concentration below the median of 11.3 nmol/l, high betaine concentration was associated with reduced CRC risk (OR: 0.71, 95% CI: 0.50–1.00, P-trend = 0.02), which was not observed for those having a higher folate status. Among women, but not men, high choline concentration was associated with decreased CRC risk (OR: 0.62, 95% CI: 0.43–0.88, P-trend = 0.01). Plasma DMG was not associated with CRC risk. Conclusions Individuals with high plasma concentrations of methionine, choline, and betaine may be at reduced risk of CRC.en_US
dc.language.isoengeng
dc.publisherOxford University Presseng
dc.subjectmethionineeng
dc.subjectCholineeng
dc.subjectBetaineeng
dc.subjectdimethylglycineeng
dc.subjectcolorectal cancer riskeng
dc.subjectpopulation-based case–control studyeng
dc.titlePlasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-02-27T11:38:03Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2014 The authors
dc.identifier.doihttps://doi.org/10.1093/annonc/mdu185
dc.identifier.cristin1166763
dc.source.journalAnnals of Oncology
dc.source.4025
dc.source.148
dc.source.pagenumber1609-1615


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