Blar i Department of Clinical Medicine på tittel
Viser treff 1377-1396 av 1495
-
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters
(Journal article; Peer reviewed, 2021)Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ... -
Targeted temperature management in cardiac arrest: survival evaluated by propensity score matching
(Peer reviewed; Journal article, 2017)Background: Targeted temperature management in cardiac arrest was introduced following evidence of increased survival from two controlled trials published in 2002. We wanted to investigate whether the introduction of ... -
Tear metabolomics in dry eye disease: A review
(Peer reviewed; Journal article, 2019-08-01)Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek ... -
Tear production levels and dry eye disease severity in a large Norwegian cohort
(Peer reviewed; Journal article, 2018)Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear ... -
Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions
(Journal article; Peer reviewed, 2021)Ocular pterygium-digital keloid dysplasia (OPDKD) presents in childhood with ingrowth of vascularized connective tissue on the cornea leading to severely reduced vision. Later the patients develop keloids on digits but are ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
(Journal article; Peer reviewed, 2021)Background: In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ... -
Temporary Prosthetic Shunt to Permanent Aortic Prosthesis in a Patient with an Infected Thoracoabdominal Aneurysm to Shorten Ischemia Time
(Peer reviewed; Journal article, 2010)High operative mortality of infected thoracoabdominal aortic aneurysms (ITAA) is partly attributable to ischemic injury during aortic clamping. We report a 62-year-old man with biliary cirrhosis, who developed a rapidly ... -
Ten-Year Results From a Phase II Study on Image Guided, Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost in High-Risk Prostate Cancer
(Journal article; Peer reviewed, 2020)Purpose There is no consensus on how to treat high-risk prostate cancer, and long-term results from hypofractionated radiation therapy are lacking. We report 10-year results after image guided, intensity modulated radiation ... -
Teriflunomide vs injectable disease modifying therapies for relapsing forms of MS
(Journal article; Peer reviewed, 2020)Multiple sclerosis (MS) is a chronic, immune-mediated, inflammatory disease affecting the white and gray matter of the central nervous system. Several disease modifying therapies (DMTs) have been shown to significantly ... -
Terminal digit preference: a source of measurement error in breast cancer diameter reporting
(Peer reviewed; Journal article, 2019)Objectives: Women diagnosed with breast cancer are offered treatment and therapy based on tumor characteristics, including tumor diameter. There is scarce knowledge whether tumor diameter is accurately reported, or whether ... -
Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest - implementation and clinical management
(Doctoral thesis, 2012-11-02)Background: With the publication of two randomized controlled trials (RCTs) in 2002, therapeutic hypothermia (TH) was re-introduced in postresuscitation care of comatose out-of-hospital cardiac arrest (OHCA) patients. Many ... -
They know! - do they? A qualitative study of residents and relatives views on advance care planning, end-of-life care, and decision-making in nursing homes.
(Peer reviewed; Journal article, 2015)Background: Residents living in long-term care facilities are a vulnerable population. For many residents, a nursing home is their place of death. Palliative care and end-of-life decisions are important components of their ... -
Thromboprophylaxis in primary shoulder arthroplasty does not seem to prevent death: a report from the Norwegian Arthroplasty Register 2005–2018
(Journal article; Peer reviewed, 2021)Background and purpose — There is still no consensus on whether to use thromboprophylaxis as a standard treatment in shoulder replacement surgery. We investigated the use of thromboprophylaxis reported to the Norwegian ... -
Thrombosis is not a marker of bridging vein rupture in infants with alleged abusive head trauma
(Journal article; Peer reviewed, 2021)Aim Thrombosis of bridging veins has been suggested to be a marker of bridging vein rupture, and thus AHT, in infants with subdural haematoma. Methods This is a non-systematic review based on Pubmed search, secondary ... -
Time course of cerebrovascular reactivity in patients treated for unruptured intracranial aneurysms: A one-year transcranial Doppler and acetazolamide follow-up study
(Peer reviewed; Journal article, 2018-04-26)Background. Cerebrovascular reactivity (CVR) is ofen impaired in the early phase afer aneurysmal subarachnoid hemorrhage. Tere is, however, little knowledge about the time course of CVR in patients treated for unruptured ... -
Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades
(Peer reviewed; Journal article, 2015-06-05)Norway has been subjected to numerous epidemiological investigations on the prevalence and incidence of multiple sclerosis (MS), dating back to 1935. The objective of this study was to review the studies on the prevalence ... -
The timing of environmental risk factors and prodromal signs of multiple sclerosis
(Doctoral thesis, 2017-12-18)Background: Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system that can lead to severe disability. It is a complex disease likely caused by genetic and environmental factors combined. ... -
Timing of hip hemiarthroplasty and the influence on prosthetic joint infection
(Journal article; Peer reviewed, 2020-03-12)Introduction Previous research suggested that patients have increased risk of infection with increased time from presentation with a femoral neck fracture to treatment with a hip hemiarthroplasty (HHA). The purpose of ... -
Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study.
(Peer reviewed; Journal article, 2015)Background: Low vitamin D levels have been associated with an increased risk of multiple sclerosis (MS), although it remains unknown whether this relationship varies by age. Objective: The objective of this paper is to ... -
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer
(Peer reviewed; Journal article, 2016-09-13)Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ...