Browsing Department of Clinical Medicine by Title
Now showing items 1389-1408 of 2172
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MRI characterisation of adult onset alpha-methylacyl-coA racemase deficiency diagnosed by exome sequencing
(Peer reviewed; Journal article, 2013-01-03)Background: Correct diagnosis is pivotal to understand and treat neurological disease. Herein, we report the diagnostic work-up utilizing exome sequencing and the characterization of clinical features and brain MRI in two ... -
MRI findings in candidates for lumbar disc prosthesis: reliability and relationship to disability and pain
(Doctoral thesis, 2014-11-21)Background and objective: In candidates for lumbar disc prosthesis, limited reliability data exist for magnetic resonance imaging (MRI) findings relevant to planning of treatment and to evaluation of outcome after treatment. ... -
MRI of Modic changes in chronic low back pain : Reliability and relation to effect of antibiotic treatment
(Doctoral thesis, 2024-12-06)Sammendrag Bakgrunn Modicforandringer (MCs) i virvelkroppene i ryggen identifiseres på T1- og T2-vektet magnetisk resonanstomografi (MR) serier, der Modic-forandringer type 1 (MC1) karakteriseres ved ødemsignaler og type ... -
MRI-assessed tumor-free distance to serosa predicts deep myometrial invasion and poor outcome in endometrial cancer
(Journal article; Peer reviewed, 2022)Objectives To explore the diagnostic accuracy of preoperative magnetic resonance imaging (MRI)-derived tumor measurements for the prediction of histopathological deep (≥ 50%) myometrial invasion (pDMI) and prognostication ... -
An mri-based radiomic prognostic index predicts poor outcome and specific genetic alterations in endometrial cancer
(Journal article; Peer reviewed, 2021)Integrative tumor characterization linking radiomic profiles to corresponding gene expression profiles has the potential to identify specific genetic alterations based on non-invasive radiomic profiling in cancer. The aim ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
(Journal article; Peer reviewed, 2020-01-16)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy ... -
mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis
(Peer reviewed; Journal article, 2008-02-13)Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order to investigate the role ... -
The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants
(Peer reviewed; Journal article, 2018)Carboxyl-ester lipase (CEL) is a pancreatic fat-digesting enzyme associated with human disease. Rare mutations in the CEL gene cause a syndrome of pancreatic exocrine and endocrine dysfunction denoted MODY8, whereas a ... -
Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L
(Journal article; Peer reviewed, 2024)Background Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens ... -
A multicenter study on Leigh syndrome: disease course and predictors of survival
(Peer reviewed; Journal article, 2014-04-15)Background: Leigh syndrome is a progressive neurodegenerative disorder, associated with primary or secondary dysfunction of the mitochondrial oxidative phosphorylation. Despite the fact that Leigh syndrome is the most ... -
Multidisciplinary intervention versus brief intervention in specialist healthcare. Attempting to improve outcomes for patients on sick leave with musculoskeletal pain
(Doctoral thesis, 2018-12-11)Background: Musculoskeletal pain (MSK), such as low back pain (LBP), neck pain and widespread pain, is among the most common health problems in industrial countries. Subsequently, MSK is associated with substantial healthcare ... -
Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study
(Journal article; Peer reviewed, 2021)Background: The impact of social media, with its speed, reach and accessibility, in interventions aimed to improve adherence to guidelines such as assessment of Pain, Agitation/Sedation and Delirium (PAD) in intensive care ... -
A multilevel, step-based model to evaluate progress in procedure efficiency for laparoscopic appendicectomy in surgical training: structured evaluation using 'ebb-and-flow' and 'string-of-pearls' concepts
(Journal article; Peer reviewed, 2022)Background Surgical training is aimed towards entrusted professional activity to obtain operative independence. Laparoscopic appendicectomy is performed early in training but except for simulators, real-life evaluation ... -
Multimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes
(Journal article; Peer reviewed, 2022)Background: Electroconvulsive therapy (ECT) is an effective treatment for severe depression and induces gray matter (GM) increases in the brain. Small-scale studies suggest that ECT also leads to changes in brain functioning, ... -
A multiomics disease progression signature of low-risk ccRCC
(Journal article; Peer reviewed, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
Multiple adversity: Childhood abuse, adult abuse, and perinatal depression in women with multiple sclerosis : A register-based cohort study
(Doctoral thesis, 2024-02-23)Bakgrunn: Stress kan spille en rolle ved multippel sklerose (MS). Stress i barndommen forårsaket av vold og overgrep er assosiert med økt risiko for kroniske sykdommer i voksen alder. Det er ukjent om slikt stress kan ... -
Multiple organ failure after trauma affects even long- term survival and functional status
(Peer reviewed; Journal article, 2007-09-04)Background The aim of this study was to assess the incidence of organ failure in trauma patients treated in an intensive care unit (ICU), and to study the relationship between organ failure and long-term survival and ... -
Multiple primary malignancies in patients with Renal Cell Carcinoma. - A national population-based cohort study
(Journal article; Peer reviewed, 2006)Objective: To determine the possibly greater occurrence of multiple malignancies in patients with renal cell carcinoma (RCC). Patients and methods: In the 7-year period 1987–93, all 1425 patients aged 15–70 years with ... -
Multiple sclerosis -the impact of environmental- and lifestyle factors
(Doctoral thesis, 2021-04-15)Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), likely caused by an interaction of genetic and environmental factors. Epstein-Barr virus infection, low serum ... -
Multiple sclerosis and pregnancy: pregnancy, delivery and birth outcome in woman with multiple sclerosis
(Doctoral thesis, 2008-09-03)This study provides information regarding birth-giving in women with multiple sclerosis (MS). MS is a common disease in the western world and causes disability in young adults and, like most immune mediated diseases, affects ...