Browsing Department of Clinical Medicine by Title
Now showing items 1500-1519 of 2215
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The Norwegian Stroke in the Young Study (NOR-SYS): rationale and design
(Peer reviewed; Journal article, 2013-07-17)Background: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The ... -
The Norwegian tenecteplase stroke trial (NOR-TEST): randomised controlled trial of tenecteplase vs. alteplase in acute ischaemic stroke
(Peer reviewed; Journal article, 2014-05-15)Background: Alteplase is the only approved thrombolytic agent for acute ischaemic stroke. The overall benefit from alteplase is substantial, but some evidence indicates that alteplase also has negative effects on the ... -
Not every estimate counts – evaluation of cell composition estimation approaches in brain bulk tissue data
(Journal article; Peer reviewed, 2023-06-07)Background: Variation in cell composition can dramatically impact analyses in bulk tissue samples. A commonly employed approach to mitigate this issue is to adjust statistical models using estimates of cell abundance derived ... -
Nothing to complain about? : residents’ and relatives’ viewson a "good life" and ethical challenges in nursing homes
(Peer reviewed; Journal article, 2014)Background: Nursing home residents are a vulnerable population. Most of them suffer from multimorbidity, while many have cognitive impairment or dementia and need care around the clock. Several ethical challenges in nursing ... -
A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer
(Journal article; Peer reviewed, 2022)Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ... -
Novel biomarkers in multiple sclerosis pathology with a focus on neuroprotection and myelin repair
(Doctoral thesis, 2024-01-16)Multippel sklerose (MS) er en sykdom som fører til skade på nervesystemet, kjennetegnet av definerte områder med vevsskade (lesjoner) i sentralnervesystemet (CNS). Dette resulterer i varig funksjonshemming hos pasienter. ... -
Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing
(Journal article; Peer reviewed, 2022)Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. ... -
Novel Methods and Sources for Regeneration of Oral Mucosa
(Doctoral thesis, 2022-06-16)Background: Common clinical approaches for replacing damaged oral mucosa are represented by autologous skin grafts which have numerous shortcomings and pose serious post-surgical morbidity. Cultured oral mucosal sheets ... -
A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study
(Journal article; Peer reviewed, 2022)Background Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ... -
Novel Nanoparticulate and Ionic Titanium Antigens for Hypersensitivity Testing
(Peer reviewed; Journal article, 2018-04-06)Titanium is used in a wide variety of materials ranging from medical devices to materials used in everyday life. Adverse biological reactions that could occur in patients, consumers, and workers should be monitored and ... -
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease
(Journal article; Peer reviewed, 2023)Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains ... -
NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study
(Journal article; Peer reviewed, 2021-09-07)Objective: Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson’s disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID ... -
Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission
(Journal article; Peer reviewed, 2020)Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ... -
The Nurse Role in the Management of ADHD in Children and Adolescent: A Literature Review
(Journal article; Peer reviewed, 2022)Objective: To review literature regarding existing and recommended roles for nurses in the management of children with ADHD. Methods: MEDLINE and CINAHL were searched from 2010 to the end of 2019 with the following ... -
Nutrients and contaminants in processed small indigenous fish species from Ghana : Implications for food and nutrition security
(Doctoral thesis, 2022-04-07)The prevalence of malnutrition is increasing globally, along with the need to access nutritious, safe and sustainable foods. Fish are known as a rich source of protein, essential fatty acids and micronutrients, and including ... -
Nutrition Education as Part of a Cancer Rehabilitation Program: Evaluation of Short Term Efficacy
(Master thesis, 2018-06-22)Background and aim: The rising number of cancer patients is being followed by increasing number of cancer survivors in Norway. Modifiable lifestyle factors such as changing dietary behaviour can benefit the cancer prognosis ... -
Nutrition in the intensive care patient
(Master thesis, 2023-05-15)Introduction Nutritional therapy in critically ill patients requires recurring assessments to accommodate the increased nutritional demands alongside the decreased tolerance for receiving nutrition in the stress-induced ... -
Nutritional and clinical status of patients with diabetes in Zanzibar: A clinical follow up study
(Master thesis, 2020-06-24) -
Nutritional risk, nutrition plan and risk of death in older health care service users with chronic diseases: A register-based cohort study
(Journal article; Peer reviewed, 2023)Background and aims Nutritional risk in older health care service users is a well-known challenge. Nutritional risk screening and individualised nutrition plans are common strategies for preventing and treating malnutrition. ...