Blar i Department of Clinical Medicine på tittel
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Cytokine Patterns in Tuberculosis Infection; IL-1ra, IL-2 and IP-10 Differentiate Borderline QuantiFERON-TB Samples from Uninfected Controls
(Peer reviewed; Journal article, 2016-09-29)Background: Interferon gamma release assays (IGRAs) do not discriminate between active tuberculosis (TB) and latent TB infection (LTBI), which limit their use in TB endemic areas. Subjects with QuantiFERON-TB (QFT) results ... -
Cytokines in Renal Cell Carcinoma : With emphasis on Vascular Endothelial Growth Factor (VEGF) and Interleukin 6 (IL-6)
(Doctoral thesis, 2021-11-12)Aims: In the first three papers we aimed to investigate if different circulating cytokines in blood drawn preoperatively can predict outcome after surgery in patients with renal cell carcinoma (RCC). The last paper aimed ... -
Data entry quality of double data entry vs automated form processing technologies: A cohort study validation of optical mark recognition and intelligent character recognition in a clinical setting
(Journal article; Peer reviewed, 2020)Background and Aims Patient-reported outcome measures (PROMs) are increasingly used in health services. Paper forms are still often used to register such data. Manual double data entry (DDE) has been defined as the gold ... -
DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder
(Peer reviewed; Journal article, 2012-04-23)Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. ... -
Deciphering the inflection points to achieve proficiency for each procedure step during training in laparoscopic appendicectomy
(Journal article; Peer reviewed, 2021)Background Laparoscopic appendicectomy is a common procedure early in surgical training. A minimum number is usually required for certification in general surgery. However, data on proficiency are scarce. This study aimed ... -
Decompression alone versusdecompression with instrumental fusionthe NORDSTEN degenerativespondylolisthesis trial (NORDSTEN-DS); study protocol for a randomized controlled trial
(Peer reviewed; Journal article, 2019-01-05)Background: Fusion in addition to decompression has become the standard treatment for lumbar spinal stenosis with degenerative spondylolisthesis (DS). The evidence for performing fusion among these patients is conflicting ... -
Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis
(Journal article; Peer reviewed, 2021)BACKGROUND In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion. METHODS We conducted an ... -
Decreased survival of medial pivot designs compared with cruciate-retaining designs in TKA without patellar resurfacing.
(Journal article; Peer reviewed, 2020)Background The medial pivot TKA design was introduced in the 1990s. These are fixed-bearing, medial-conforming implants with virtually no translation in the medial part of the knee, in contrast to the flat lateral part ... -
Default-mode network functional connectivity is closely related to metabolic activity
(Peer reviewed; Journal article, 2015-06)Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ... -
Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA
(Peer reviewed; Journal article, 2014-06-05)Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we ... -
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
(Peer reviewed; Journal article, 2016-11-22)Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ... -
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Peer reviewed; Journal article, 2014-02-19)Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ... -
Defining Transabdominal Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease: Systematic Review and Expert Consensus Statement
(Journal article; Peer reviewed, 2021)Background and Aims No consensus exists on defining intestinal ultrasound response, transmural healing, or transmural remission in inflammatory bowel disease, nor clear guidance for optimal timing of assessment during ... -
Deformation and initial stability in hip arthroplasty. Effect of neck geometry and fixation – an experimental cadaver study
(Doctoral thesis, 2017-06-08)Introduction: The search for and development of the optimal joint implant include preclinical testing. Restoration of the individual and natural biomechanics in the hip joint is a central goal in hip arthroplasty, and can ... -
Demens med Lewylegemer: søvn, kognisjon og nevropatologi
(Doctoral thesis, 2019-01-17)Background Sleep disorders are frequent in patients with dementia. Sleep disturbances can negatively influence the disease burden of dementia and accelerate the rate of cognitive decline. It is hypothesized that sleep ... -
Dementia with Lewy Bodies. Identification, frequency and sleep-disturbances. A cross-sectional clinical dementia cohort study
(Doctoral thesis, 2011-02-18)Background: Dementia with Lewy Bodies (DLB) has existed as a formal consensus diagnosis since 1996 and is defined by dementia and the core features parkinsonism, visual hallucinations and cognitive fluctuations. The original ... -
Densities of rectal peptide YY and somatostatin cells as biomarkers for the diagnosis of irritable bowel syndrome
(Peer reviewed; Journal article, 2015-03-09)Irritable bowel syndrome (IBS) is a common chronic disorder. IBS diagnosis is a diagnosis of exclusion since there are no blood tests, radiological or endoscopic examinations for this disorder. Although several attempts ... -
Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome
(Journal article; Peer reviewed, 2020)Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic ... -
Depresjon og andre subjektive helseplager hos pasientar med korsryggsmerter. Har inntak av sjømat og vitamin D-status noko betyding?
(Master thesis, 2014-05-15)Background: Vitamin D is found in limited selections of food, among other fatty fish and fish liver, as well as fortified food such as margarine and milk. Other vitamin D sources are dietary supplements and sunlight. Low ... -
Depression and migraine comorbid to diabetes
(Doctoral thesis, 2014-12-04)Background: Diabetes, depression and migraine are prevalent diseases in the Norwegian population, and have great impact on patients life in terms of disability. Diabetes is a systemic disease manifesting in a range of organ ...