Browsing Department of Clinical Medicine by Title
Now showing items 451-470 of 2112
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Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome
(Journal article; Peer reviewed, 2020)Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic ... -
Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations
(Journal article; Peer reviewed, 2023)Mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ), lead to diseases driven by defective mtDNA maintenance. Despite being the most prevalent cause of ... -
Depresjon og andre subjektive helseplager hos pasientar med korsryggsmerter. Har inntak av sjømat og vitamin D-status noko betyding?
(Master thesis, 2014-05-15)Background: Vitamin D is found in limited selections of food, among other fatty fish and fish liver, as well as fortified food such as margarine and milk. Other vitamin D sources are dietary supplements and sunlight. Low ... -
Depression and migraine comorbid to diabetes
(Doctoral thesis, 2014-12-04)Background: Diabetes, depression and migraine are prevalent diseases in the Norwegian population, and have great impact on patients life in terms of disability. Diabetes is a systemic disease manifesting in a range of organ ... -
Depression in Parkinson’s disease
(Doctoral thesis, 2010-05-07) -
Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study
(Journal article; Peer reviewed, 2023)Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity in the immune system is seen in both depression and schizophrenia. We aimed to uncover depressive trajectories in a sample ... -
Depressive symptoms in psychotic disorders : Trajectories of depression and antidepressive effectiveness of antipsychotic medication
(Doctoral thesis, 2020-10-16)Background: Depressive symptoms are common in psychotic disorders and contribute to impaired functioning, a poorer quality of life, elevated relapse rate and suicide risk. Depression in schizophrenia may emerge as part of ... -
Detection and significance of small and low proliferation breast cancer
(Journal article; Peer reviewed, 2022)Objectives To determine the frequency and discuss possible implications of early breast cancer with particularly good prognosis and defined by tumor diameter and cell proliferation. Setting Detection of small and ... -
Determinants and Consequences of Nutritional Status in Patients with Chronic Kidney Disease
(Doctoral thesis, 2022-10-20)Bakgrunn: Pasienter med kronisk nyresykdom møter mangfoldige utfordringer vedrørende deres ernæringsstatus, relatert til redusert nyrefunksjon, påfølgende metabolske forandringer, mangfoldige komorbiditeter og polyfarmasi. ... -
Determinants of vitamin D status
(Master thesis, 2020-06-27) -
Determining universal processes related to best outcome in emergency abdominal surgery: A multicentre, international, prospective cohort study
(Peer reviewed; Journal article, 2014-10-29)Introduction: Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, ... -
Developing a novel femoral stem in hip arthroplasty. An innovation process using a weight-bearing animal model
(Doctoral thesis, 2015-08-20)Introduction: To address the growing incidence of hip replacement revision, this project aimed to find a stem that would fulfil three criteria. First, solid osteointegration and long survival of the implant. Second, easy ... -
Developing a rodent model for antipsychotic-induced metabolic adverse effects
(Doctoral thesis, 2012-04-20)Antipsychotic agents represent efficient therapy for serious psychiatric disorders, particularly schizophrenia, but also bipolar disorder, and are used by millions of patients worldwide. Metabolic adverse effects of ... -
Developing nephrology services in low income countries: A case of Tanzania
(Peer reviewed; Journal article, 2019-10-17)Background: The burden of kidney diseases is reported to be higher in lower- and middle-income countries as compared to developed countries, and countries in sub-Saharan Africa are reported to be most affected. Health ... -
Development and clinical implementation of a structured, simulation-based training programme in laparoscopic appendectomy: Description, validation and evaluation
(Journal article; Peer reviewed, 2021)Background: Laparoscopic appendectomy is a common procedure in general surgery but is likely underused in structured and real-life teaching. This study describes the development, validation and evaluation of implementing ... -
Development and feasibility testing of a physical activity intervention for youth with anxiety and depression: a study protocol
(Journal article; Peer reviewed, 2022)Background Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety, and depression lead to numerous ... -
Development and Optimization of a Multilayer Rat Purkinje Neuron Culture
(Journal article; Peer reviewed, 2023)Elucidation of the mechanisms involved in neurodegenerative diseases of the cerebellum has been hampered by the lack of robust single cell models to study Purkinje neurons and replicate at the same time in vivo features. ... -
Development and validation of a multimodal neuroimaging biomarker for electroconvulsive therapy outcome in depression: A multicenter machine learning analysis
(Journal article; Peer reviewed, 2023)Background Electroconvulsive therapy (ECT) is the most effective intervention for patients with treatment resistant depression. A clinical decision support tool could guide patient selection to improve the overall ... -
Development and Validation of a Simple Ultrasound Activity Score for Crohn’s Disease
(Journal article; Peer reviewed, 2020-06-06)Background and Aims To improve management of patients with Crohn’s disease, objective measurements of disease activity are needed. Ileocolonoscopy is the current reference standard but has limitations that restrict repeated ... -
Development and validation of patients' surgical safety checklist
(Journal article; Peer reviewed, 2022)Background: Poor uptake and understanding of critical perioperative information represent a major safety risk for surgical patients. Implementing a patient-driven surgical safety checklist might enhance the way critical ...