• Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain 

      Toker, Lilah; Tran, Gia T.; Sundaresan, Janani; Tysnes, Ole-Bjørn; Alves, Guido; Haugarvoll, Kristoffer; Nido, Gonzalo S.; Dölle, Christian; Tzoulis, Charalampos (Journal article; Peer reviewed, 2021)
      Background: Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic ...
    • Genome-wide transcription analysis of histidine-related cataract in Atlantic salmon (Salmo salar L) 

      Tröße, Christiane; Waagbø, Rune; Breck, Olav; Stavrum, Anne-Kristin; Petersen, Kjell; Olsvik, Pål A. (Peer reviewed; Journal article, 2009-07-09)
      Purpose: Elevated levels of dietary histidine have previously been shown to prevent or mitigate cataract formation in farmed Atlantic salmon (Salmo salar L). The aim of this study was to shed light on the mechanisms by ...
    • Genotype dependent gene regulation in visceral adiposity: a study of the 11q23.3 locus 

      Mirza, Shanima Shanu (Master thesis, 2022-05-30)
      Abstract Background: Overweight and obesity are defined by an excessive accumulation of adipose tissue. Adipose tissue, also known as fat, consist of specialized lipid storing cells called adipocytes. In human, adipose ...
    • Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders 

      Mannucci, Ilaria; Dang, Nghi D. P.; Huber, Hannes; Murry, Jaclyn B.; Abramson, Jeff; Althoff, Thorsten; Banka, Siddharth; Baynam, Gareth; Bearden, David; Beleza-Meireles, Ana; Benke, Paul J.; Berland, Siren; Bierhals, Tatjana; Bilan, Frédéric; Bindoff, Laurence A.; Braathen, Geir Julius; Busk, Øyvind; Chenbhanich, Jirat; Denecke, Jonas; Escobar, Luis F.; Estes, Caroline; Fleischer, Julie; Groepper, Daniel; Haaxma, Charlotte A.; Hempel, Maja; Holler-Managan, Yolanda; Houge, Gunnar Douzgos; Jackson, Adam; Kellogg, Laura; Keren, Boris; Kiraly-Borri, Catherine; Kraus, Cornelia; Kubisch, Christian; Le Guyader, Gwenaël; Ljungblad, Ulf Wike; Martinez-Agosto, Julian A.; Brenman, Leslie Manace; Might, Matthew; Miller, David T.; Minks, Kelly Q.; Moghaddam, Billur; Nava, Caroline; Nelson, Stanley F.; Parant, John M.; Prescott, Trine; Rajabi, Farrah; Randrianaivo, Hanitra; Reiter, Simone B. C. Frizell; Schuurs-Hoeijmakers, Janneke; Shieh, Perry B.; Slavotinek, Anne; Smithson, Sarah; Stegmann, Alexander P. A.; Tomczak, Kinga; Tveten, Kristian; Wang, Jun; Whitlock, Jordan H.; Zweier, Christiane; McWalter, Kirsty; Juusola, Jane; Quintero-Rivera, Fabiola; Fischer, Utz; Yeo, Nan Cher; Kreienkamp, Hans-Jürgen; Lessel, Davor (Journal article; Peer reviewed, 2021)
      Background: We aimed to define the clinical and variant spectrum and to provide novel molecular insights into the DHX30-associated neurodevelopmental disorder. Methods: Clinical and genetic data from affected individuals ...
    • A gentle introduction to instrumental variables 

      Widding-Havneraas, Tarjei; Zachrisson, Henrik Daae (Journal article; Peer reviewed, 2022)
      Instrumental variables (IV) is a central strategy for identifying causal effects in absence of randomized experiments. Clinicians and epidemiologists may find the intuition of IV easy to grasp by comparison to randomized ...
    • Geographical accessibility and duration of untreated psychosis: Distance as a determinant of treatment delay 

      Kvig, Erling Inge; Brinchmann, Beate; Moe, Cathrine Fredriksen; Nilssen, Steinar; Larsen, Tor Ketil; Sørgaard, Knut W. (Peer reviewed; Journal article, 2017-05-10)
      Background: The duration of untreated psychosis is determined by both patient and service related factors. Few studies have considered the geographical accessibility of services in relation to treatment delay in early ...
    • Geographical variation in ADHD: do diagnoses refect symptom levels? 

      Widding-Havneraas, Tarjei; Markussen, Simen; Elwert, Felix; Lyhmann, Ingvild; Bjelland, Ingvar; Halmøy, Anne; Chaulagain, Ashmita; Ystrøm, Eivind; Mykletun, Arnstein; Zachrisson, Henrik Daae (Journal article; Peer reviewed, 2023)
      Rates of ADHD diagnosis vary across regions in many countries. However, no prior study has investigated how much within-country geographic variation in ADHD diagnoses is explained by variation in ADHD symptom levels. We ...
    • Geographical variation in orthopedic procedures in Norway: Cross-sectional population-based study 

      Holsen, Maria; Hovind, Veronica; Bedane, Haji Kedir; Osvoll, Knut Ivar; Gjertsen, Jan-Erik; Furnes, Ove Nord; Walsh, Mary E.; Ingebrigtsen, Tor (Journal article; Peer reviewed, 2022)
      Background: Standardized surgery rates for common orthopedic procedures vary across geographical areas in Norway. We explored whether area-level factors related to demand and supply in publicly funded healthcare are ...
    • Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia 

      Dalmasso, Bruna; Pastorino, Lorenza; Nathan, Vaishnavi; Shah, Nirav N.; Palmer, Jane M.; Howlie, Madeleine; Johansson, Peter A.; Freedman, Neal D.; Carter, Brian D.; Beane-Freeman, Laura E.; Hicks, Belynda D.; Molven, Anders; Helgadottir, Hildur; Sankar, Aravind; Tsao, Hensin; Stratigos, Alexander J.; Helsing, Per; van Doorn, Remco; Gruis, Nelleke A.; Visser, Mijke; Wadt, Karin Anna Wallentin; Mann, G.; Holland, Elizabeth A.; Nagore, Eduardo; Potrony, Miriam; Puig, Susana; Menin, Chiara; Peris, Ketty; Fargnoli, Maria Concetta; Calista, Donato; Soufir, Nadem; Harland, Mark; Bishop, Timmi Unger; Kanetsky, Peter A.; Elder, David E.; Andreotti, Virginia; Vanni, Irene; Bruno, William; Höiom, Veronica; Tucker, Margaret Anne; Yang, Xiaohong R.; Andresen, Per Arne; Adams, David James; Landi, Maria Teresa; Hayward, Nicholas K.; Goldstein, Alisa M.; Ghiorzo, Paola (Journal article; Peer reviewed, 2021)
      Purpose Ataxia–Telangiectasia Mutated (ATM) has been implicated in the risk of several cancers, but establishing a causal relationship is often challenging. Although ATM single-nucleotide polymorphisms have been linked ...
    • "Getting your message through": an editorial guide for meeting publication standards 

      Ringdal, Kjetil Gorseth; Lossius, Hans Morten; Søreide, Kjetil (Peer reviewed; Journal article, 2009-12-23)
    • Glioma-associated epilepsy : and the treatment with antiepileptic drugs 

      Knudsen-Baas, Kristin M. (Doctoral thesis, 2020-01-23)
      Background: Gliomas are primary brain tumors with a risk of epileptic seizures that especially depends on subtype. Whether epilepsy or anti-epileptic drugs (AEDs) prolong survival in patients with glioblastoma (GBM) is a ...
    • Global economic burden of unmet surgical need for appendicitis 

      Reuter, Anna; Rogge, Lisa; Monahan, Mark; Kachapila, Mwayi; Morton, Dion G; Davies, Justine I; Søreide, Kjetil; Augestad, Knut Magne; Vollmer, Sebastian; Essam, AA; Elkhalek Sallam, Abd; Elrahman Elshafay, Abd; El-Rahman Hegazy Khedr, Abd; Gamal Saad, Abdalla; Gharib, Abdalla; Kenibar, Abdalla; Salah Elsherbiny, Abdalla; Adel, Abdalrahman; Abdelaal, Abdelaziz; Osman Abdelaziz Elhendawy, Abdelaziz; Hussein, Abdelfatah; Belkouchi, Abdelkader; Hrora, Abdelmalek; Adelshone, Abdelrahman; Alkammash, Abdelrahman; Abdelrahman, Assal; Geuoshy, Abdelrahman; Haroun, Abdelrahman; Mohammed, Abdelrahman; Sayed, Abdelrahman; Soliman, Abdelrahman; Essam Elnemr, Abdelrahman; Darwish, Abdelrhman KZ; Osama Elsebaaye, Abdelrahman; Khalique, Abdul; Rehman Alvi, Abdul; Wahid Anwar, Abdul; Altwijri, Abdulaziz; Al-Mallah, Abdullah; Almoflihi, Abdullah; Altamimi, Abdullah; Daqeeq, Abdullah; Dwydar, Abdullah; Gouda, Abdullah; Hashim, Abdullah; Altaf, Abdulmalik; Huwait, Abdulmalik; Abdel-Aty, Abdulrahman; Altwigry, Abdulrahman M.; Sheshe, Abdulrahman; Nasir, Abdulrasheed A (Journal article; Peer reviewed, 2022)
      Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of ...
    • Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies 

      Søreide, Kjetil; Sandvik, Oddvar Mathias; Søreide, Jon Arne; Giljaca, Vanja; Jureckova, Andrea; Bulusu, V. Ramesh (Peer reviewed; Journal article, 2015-02)
      Background: Gastrointestinal stromal tumours (GISTs) are rare, yet the most common mesenchymal tumour within the digestive tract. Lack of diagnostic criteria and no specific code in the ICD system has prevented epidemiological ...
    • Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9 

      Murphy, Lindsay B.; Schreiber-Katz, Olivia; Rafferty, Karen; Robertson, Agata; Topf, Ana; Willis, Tracey A.; Heidemann, Marcel; Thiele, Simone; Bindoff, Laurence; Laurent, Jean-Pierre; Lochmüller, Hanns; Mathews, Katherine; Mitchell, Claudia; Stevenson, John Herbert; Vissing, John; Woods, Lacey; Walter, Maggie C.; Straub, Volker (Journal article; Peer reviewed, 2020-04)
      Objective The Global FKRP Registry is a database for individuals with conditions caused by mutations in the Fukutin‐Related Protein (FKRP) gene: limb girdle muscular dystrophy R9 (LGMDR9, formerly LGMD2I) and congenital ...
    • Global inequities in precision medicine and molecular cancer research 

      Drake, Thomas M.; Knight, Stephen R.; Harrison, Ewen M.; Søreide, Kjetil (Peer reviewed; Journal article, 2018-09-04)
      Precision medicine based upon molecular testing is heralded as a revolution in how cancer is prevented, diagnosed, and treated. Large efforts across the world aim to conduct comprehensive molecular profiling of disease to ...
    • Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells 

      Ke, Xi-Song; Qu, Yi; Cheng, Yang; Li, Wen-Cheng; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning (Peer reviewed; Journal article, 2010-11-25)
      Background: Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA ...
    • Global surgery, obstetric, and anaesthesia indicator definitions and reporting: An Utstein consensus report 

      Davies, Justine I; Gelb, Adrian W.; Gore-Booth, Julian; Martin, Janet; Mellin-Olsen, Jannicke; Åkerman, Christina; Ameh, Emmanuel A.; Biccard, Bruce M.; Braut, Geir Sverre; Chu, Kathryn M.; Derbew, Miliard; Ersdal, Hege Langli; Guzman, Jose Miguel; Hagander, Lars; Haylock-Loor, Carolina; Holmer, Hampus; Johnson, Walter; Juran, Sabrina; Kassebaum, Nicolas J.; Lærdal, Tore; Leather, Andrew J.M.; Lipnick, Michael S.; Ljungman, David; Makasa, Emmanuel Malabo Mwenda; Meara, John G.; Newton, Mark W.; Østergaard, Doris; Reynolds, Teri; Romanzi, Lauri J.; Santhirapala, Vatshalan; Shrime, Mark G.; Søreide, Kjetil; Steinholt, Margit; Suzuki, Emi; Varallo, John E.; Visser, Gerard H.A.; Watters, David; Weiser, Thomas G. (Journal article; Peer reviewed, 2021)
      Background Indicators to evaluate progress towards timely access to safe surgical, anaesthesia, and obstetric (SAO) care were proposed in 2015 by the Lancet Commission on Global Surgery. These aimed to capture access to ...
    • Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine Maria; Marti, Hans-Peter; Mollnes, Tom Eirik; Berven, Frode; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2017-08-14)
      Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with ...
    • Glomerular and tubular proteome markers of progressive IgA nephropathy 

      Paunas, Flavia Teodora Ioana (Doctoral thesis, 2022-06-03)
      Background: IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, with a clinical course ranging from asymptomatic non-progressive to aggressive and progressive disease to kidney failure. The exact ...