• A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer 

      Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge (Peer reviewed; Journal article, 2016-12)
      Background: The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to ...
    • Human pancreatic glucokinase. Structural and physico-chemical studies related to catalytic activation, kinetic cooperativity and GCK-diabetes. 

      Molnes, Janne (Doctoral thesis, 2012-10-19)
      Glucokinase (GK) functions as a glucose sensor in insulin-producing pancreatic-cells and as a regulator of hepatic glycolysis, glycogen synthesis and gluconeogenesis. Its key role in glucose homeostasis is evidenced by ...
    • Human seroprevalence of antibodies to tick-borne microbes in southern Norway 

      Thortveit, Erik Thomas; Aase, Audun; Petersen, Lizette Balle; Lorentzen, Åslaug Rudjord; Mygland, Åse; Ljøstad, Unn (Journal article; Peer reviewed, 2020)
      The tick Ixodes ricinus is widespread along the coastline of southern Norway, but data on human exposure to tick-borne microbes are scarce. We aimed to assess the seroprevalence of IgG antibodies to various tick-borne ...
    • Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations 

      König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine; Vaage, Eline Benno; Mygland, Åse Daasvand; Wergeland, Stig; Aarseth, Jan Harald; Aaberge, Ingeborg Sundsvalen; Torkildsen, Øivind; Holmøy, Trygve; Berge, Tone; Myhr, Kjell-Morten; Harbo, Hanne-Cathrin Flinstad; Andersen, Jan Terje; Munthe, Ludvig Andre; Søraas, Arne Vasli; Celius, Elisabeth Gulowsen; Vaage, John T.; Lund-Johansen, Fridtjof; Nygaard, Gro Owren (Journal article; Peer reviewed, 2021)
      Introduction The effect of disease-modifying therapies (DMT) on vaccine responses is largely unknown. Understanding the development of protective immunity is of paramount importance to fight the COVID-19 pandemic. Objective ...
    • Humoral response to Epstein-Barr virus in patients with multiple sclerosis treated with B cell depletion therapy 

      Rød, Brit Ellen; Wergeland, Stig; Bjørnevik, Kjetil Lauvland; Holmøy, Trygve; Ulvestad, Elling; Njølstad, Gro; Myhr, Kjell-Morten; Torkildsen, Øivind (Journal article; Peer reviewed, 2023)
      Background B cell depletion therapy is highly effective in relapsing-remitting multiple sclerosis (RRMS). However, the precise underlying mechanisms of action for its biological effects in MS have still not been clarified. ...
    • Hydroxyapatite coating does not improve uncemented stem survival after total hip arthroplasty!: An analysis of 116,069 THAs in the Nordic Arthroplasty Register Association (NARA) database 

      Hailer, Nils P.; Lazarinis, Stergios; Mäkelä, Keijo T.; Eskelinen, Antti; Fenstad, Anne Marie; Hallan, Geir; Havelin, Leif Ivar; Overgaard, Søren; Pedersen, Alma B.; Mehnert, Frank; Kärrholm, Johan (Peer reviewed; Journal article, 2014-09-01)
      Background and purpose — It is still being debated whether HA coating of uncemented stems used in total hip arthroplasty (THA) improves implant survival. We therefore investigated different uncemented stem brands, with and ...
    • HYPERAKTIV: An Activity Dataset from Patients with Attention-Deficit/Hyperactivity Disorder (ADHD) 

      Hicks, Steven; Stautland, Andrea; Fasmer, Ole Bernt; Førland, Wenche; Hammer, Hugo Lewi; Halvorsen, Pål; Mjeldheim, Kristin; Ødegaard, Ketil Joachim; Osnes, Berge; Syrstad, Vigdis Elin Giæver; Riegler, Michael; Jakobsen, Petter (Chapter, 2021)
      Machine learning research within healthcare frequently lacks the public data needed to be fully reproducible and comparable. Datasets are often restricted due to privacy concerns and legal requirements that come with ...
    • Hyperferritinemi-katarakt-syndrom 

      Benneche, Andreas; Sandnes, Miriam; Bakke, Åsne; Reikvam, Håkon (Journal article; Peer reviewed, 2020)
    • Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors 

      Raa, Anette; Stansberg, Christine; Steen, Vidar Martin; Bjerkvig, Rolf; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Journal article, 2007-01-30)
      This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. Methods: One group of animals was exposed to normobaric ...
    • Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediaterisk human prostate cancer 

      Sushentsev, Nikita; McLean, Mary A.; Warren, Anne Y.; Benjamin, Arnold J. V.; Brodie, Cara; Frary, Amy; Gill, Andrew B.; Jones, Julia; Kaggie, Joshua D.; Lamb, Benjamin W.; Locke, Matthew J.; Miller, Jodi L.; Mills, Ian; Priest, Andrew N.; Robb, Fraser J. L.; Shah, Nimish; Schulte, Rolf S.; Graves, Martin J.; Gnanapragasam, Vincent J.; Brindle, Kevin M.; Barrett, Tristan; Gallagher, Ferdia A. (Journal article; Peer reviewed, 2022)
      Hyperpolarised magnetic resonance imaging (HP 13C-MRI) is an emerging clinical technique to detect [1-13C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised [1-13C]pyruvate. Here ...
    • Hypoglycemia and decreased insulin requirement caused by malignant insulinoma in a type 1 diabetic patient: when the hoof beats are from a zebra, not a horse 

      Gjelberg, Hilde K; Hoem, Dag; Verbeke, Caroline Sophie; Eide, Johan; Cooper, John; Molven, Anders (Peer reviewed; Journal article, 2017-06)
      Insulinomas are uncommon tumors, and in patients with diabetes mellitus they are extremely rare. We describe a patient with type 1 diabetes who developed malignant insulinoma. When hypoglycemic episodes persist in a patient ...
    • Hypoxia induced responses are reflected in the stromal proteome of breast cancer 

      Kjølle, Silje; Finne, Kenneth; Birkeland, Even; Ardawatia, Vandana; Winge, Ingeborg; Aziz, Sura Mohammed; Knutsvik, Gøril; Wik, Elisabeth; Paulo, Joao A.; Vethe, Heidrun; Kleftogiannis, Dimitrios; Akslen, Lars Andreas (Journal article; Peer reviewed, 2023)
      Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like) ...
    • Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach 

      Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Journal article; Peer reviewed, 2023)
      Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ...
    • Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders 

      Karadag, Naz; Shadrin, Alexey; O'Connell, Kevin S; Hindley, Guy Frederick Lanyon; Rahman, Zillur; Parker, Nadine; Bahrami, Shahram; Fominykh, Vera; Cheng, Weiqiu; Holen, Børge; Alvestad, Silje; Taubøll, Erik; Steen, Nils Eiel; Djurovic, Srdjan; Dale, Anders M; Frei, Oleksandr; Andreassen, Ole; Smeland, Olav Bjerkehagen (Journal article; Peer reviewed, 2023)
      Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity and overlapping symptoms. However, the causative mechanisms underlying this relationship are poorly understood. Here we aimed to ...
    • Identifying possible biomarkers of lower urinary tract symptoms using metabolomics and partial least square regression 

      Hopland-Nechita, Florin Vasile; Andersen, John Roger; Rajalahti, Tarja; Andreassen, Trygve; Beisland, Christian (Journal article; Peer reviewed, 2023)
      Introduction The objective of this study was to explore potential novel biomarkers for moderate to severe lower urinary tract symptoms (LUTS) using a metabolomics-based approach, and statistical methods with significant ...
    • Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort 

      Westerlind, Helga; Imrell, Kerstin; Ramanujam, Ryan; Myhr, Kjell-Morten; Celius, Elisabeth Gulowsen; Harbo, Hanne Flinstad; Oturai, Annette Bang; Hamsten, Anders; Alfredsson, Lars; Olsson, Tomas; Kockum, Ingrid; Koski, Timo; Hillert, Jan (Peer reviewed; Journal article, 2015)
      In an attempt to map chromosomal regions carrying rare gene variants contributing to the risk of multiple sclerosis (MS), we identified segments shared identical-by-descent (IBD) using the software BEAGLE 4.0’s refined IBD ...
    • An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver 

      Fernández Moro, Carlos; Geyer, Natalie; Harrizi, Sara; Hamidi, Yousra; Söderqvist, Sara; Kuznyecov, Danyil; Tidholm Qvist, Evelina; Salmonson Schaad, Media; Hermann, Laura; Lindberg, Amanda; Heuchel, Rainer L.; Martín-Bernabé, Alfonso; Dhanjal, Soniya; Navis, Anna C.; Villard, Christina; del Valle, Andrea C.; Bozóky, Lorand; Sparrelid, Ernesto; Dirix, Luc; Strell, Carina; Östman, Arne; Schmierer, Bernhard; Vermeulen, Peter B.; Engstrand, Jennie; Bozóky, Béla; Gerling, Marco (Journal article; Peer reviewed, 2023)
      A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule’s extent and cellular composition in 263 patients with ...
    • IgA-nefropati 

      Haaskjold, Yngvar Lunde; Knoop, Thomas (Journal article; Peer reviewed, 2022)
      Immunglobulin A-nefropati (IgA-nefropati) er den vanligste formen for primær glomerulonefritt i verden og en hyppig årsak til alvorlig nyresvikt hos unge voksne. Diagnosen stilles ved nyrebiopsi. Til tross for at sykdommen ...
    • IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age 

      Berget, Ellen; Molven, Anders; Løkeland, Turid; Helgeland, Lars; Vintermyr, Olav Karsten (Peer reviewed; Journal article, 2015-07)
      Follicular lymphoma (FL) is a heterogeneous disease with some patients developing progressively or transformed disease early, whereas others follow an indolent clinical course. We evaluated the prognostic value of ...