• AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction 

      Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)
      The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ...
    • Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model 

      Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)
      Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ...
    • Dynamics of Plasma and Urinary Extracellular DNA in Acute Kidney Injury 

      Jančuška, Alexander; Potočárová, Alena; Kovalčíková, Alexandra Gaál; Podracká, L’Udmila; Babickova, Janka; Celec, Peter; Tóthová, L’Ubomíra (Journal article; Peer reviewed, 2022)
      Early and reliable markers of acute kidney injury (AKI) are essential. One such candidate marker of tissue damage is extracellular DNA (ecDNA). The aim of our present study is to describe the unknown dynamics of ecDNA in ...
    • The Effect of Melatonin on Periodontitis 

      Konečná, Barbora; Chobodová, Paulína; Janko, Jakub; Baňasová, Lenka; Babickova, Janka; Celec, Peter; Tóthová, L’Ubomíra (Journal article; Peer reviewed, 2021)
      Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute ...
    • Extracellular DNA concentrations in various aetiologies of acute kidney injury 

      Gaál Kovalčíková, Alexandra; Janovičová, Ľubica; Hodosy, Július; Babickova, Janka; Vavrincová-Yaghi, Diana; Vavrinec, Peter; Boor, Peter; Podracká, Ľudmila; Šebeková, Katarína; Celec, Peter; Tóthová, Ľubomíra (Journal article; Peer reviewed, 2022)
      Extracellular DNA (ecDNA) in plasma is a non-specific biomarker of tissue damage. Urinary ecDNA, especially of mitochondrial origin, is a potential non-invasive biomarker of kidney damage. Despite prominent tissue damage, ...
    • Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca2+ Signaling Similar to Fabry Disease 

      Elsaid, Hassan Osman Alhassan; Tjeldnes, Håkon; Rivedal, Mariell Lossius; Serre, Camille Julia; Eikrem, Øystein Solberg; Svarstad, Einar; Tøndel, Camilla; Marti, Hans Peter; Furriol, Jessica; Babickova, Janka (Journal article; Peer reviewed, 2022)
      Fabry disease (FD) is an X-linked inborn metabolic disorder due to partial or complete lysosomal α-galactosidase A deficiency. FD is characterized by progressive renal insufficiency and cardio- and cerebrovascular involvement. ...
    • Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts 

      Kipp, Anne; Marti, Hans Peter; Babickova, Janka; Nakken, Sigrid; Leh, Sabine; Strøm Halden, Thea Anine; Jenssen, Trond; Vikse, Bjørn Egil; Åsberg, Anders; Spagnoli, Giulio; Furriol, Jessica (Journal article; Peer reviewed, 2023)
      Background Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM ...
    • Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission 

      Vrablicova, Zuzana; Tomova, Kristina; Tothova, Lubomira; Babickova, Janka; Gromova, Barbora; Konecna, Barbora; Liptak, Robert; Hlavaty, Tibor; Gardlik, Roman (Journal article; Peer reviewed, 2020)
      Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ...
    • Oxidative Stress in Animal Models of Acute and Chronic Renal Failure 

      Gyuraszova, Marianna; Kovalcikova, Alexandra Gaal; Renczes, Emese; Kmetova, Katarina; Celec, Peter; Babickova, Janka; Tothova, Lubomira (Peer reviewed; Journal article, 2019-02-11)
      Introduction. Kidney disease is a worldwide health and economic burden, with rising prevalence. The search for biomarkers for earlier and more effective disease screening and monitoring is needed. Oxidative stress has been ...
    • Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers 

      Gyurászová, Marianna; Gurecká, Radana; Babickova, Janka; Tóthová, Ľubomíra (Journal article; Peer reviewed, 2020)
      Kidney disease represents a serious global health problem. One of the main concerns is its late diagnosis, only feasible in a progressed disease state. The lack of a clinical manifestation in the early stages and the fact ...
    • Plasma Concentrations of Extracellular DNA in Acute Kidney Injury 

      Homolová, Jordanka; Janovičová, L'ubica; Konečná, Barbora; Vlková, Barbora; Celec, Peter; Tóthová, L'ubomíra; Babickova, Janka (Journal article; Peer reviewed, 2020)
      Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma. A rapid turnover ...
    • Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease 

      Elsaid, Hassan Osman Alhassan; Rivedal, Mariell Lossius; Skandalou, Eleni; Svarstad, Einar; Tøndel, Camilla; Birkeland, Even; Eikrem, Øystein Solberg; Babickova, Janka; Marti, Hans Peter; Furriol, Jessica (Journal article; Peer reviewed, 2023)
      Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ...
    • Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype 

      Elsaid, Hassan Osman Alhassan; Furriol, Jessica; Blomqvist, Maria; Diswall, Mette; Leh, Sabine; Gharbi, Naouel; Anonsen, Jan Haug; Babickova, Janka; Tøndel, Camilla; Svarstad, Einar; Marti, Hans Peter; Krause, Maximilian (Journal article; Peer reviewed, 2022)
      Fabry disease (FD) is a rare genetic lysosomal storage disorder, resulting from partial or complete lack of alpha-galactosidase A (α-GAL) enzyme, leading to systemic accumulation of substrate glycosphingolipids with a broad ...
    • Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys 

      Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral; Fossan, Kjell Ove; Leh, Sabine; Landolt, Lea; Babickova, Janka; Gudbrandsen, Oddrun Anita; Gilja, Odd Helge; Riedel, Bettina Maria Ingeborg; Schjøtt, Jan Didrik; McCormack, Emmet; Marti, Hans-Peter (Journal article; Peer reviewed, 2021-11-29)
      The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ...