Browsing Department of Clinical Medicine by Author "LaBarge, Mark A."

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Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation

Miyano, Masaru; Sayaman, Rosalyn W.; Shalabi, Sundus F.; Senapati, Parijat; Lopez, Jennifer C.; Angarola, Brittany Lynn; Hinz, Stefan; Zirbes, Arrianna; Anczukow, Olga; Yee, Lisa D.; Sedrak, Mina S.; Stampfer, Martha R.; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)

A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of ELF5, a transcription factor critical for normal mammary development, is downregulated in mammary ...
Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression

Zirbes, Arrianna; Joseph, Jesuchristopher; Lopez, Jennifer C.; Sayaman, Rosalyn W.; Basam, Mudaser; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)

A majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women more susceptible to cancer initiation. Immune-epithelial cell ...