Browsing Department of Clinical Medicine by Title
Now showing items 1500-1519 of 2044
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Personalized estimation of one-year mortality risk after elective hip or knee arthroplasty for osteoarthritis.
(Journal article; Peer reviewed, 2020)Aims To develop and validate patient-centred algorithms that estimate individual risk of death over the first year after elective joint arthroplasty surgery for osteoarthritis. Methods A total of 763,213 hip and knee ... -
The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample
(Peer reviewed; Journal article, 2016-05-05)Background: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization ... -
Pharmacokinetics of epinephrine during cardiac arrest: A pilot study
(Journal article; Peer reviewed, 2023)Aim of the study: Epinephrine has been recommended for several decades for the treatment of cardiac arrest. However, although this potent medicament has a documented impact on the return of spontaneous circulation, it does ... -
The pharmacokinetics, safety, and tolerability of mirabegron in children and adolescents with neurogenic detrusor overactivity or idiopathic overactive bladder and development of a population pharmacokinetic model-based pediatric dose estimation
(Peer reviewed; Journal article, 2019-10-22)Introduction: Mirabegron, a selective β3-adrenoreceptor agonist, is a well-established alternative to antimuscarinics in adults with overactive bladder (OAB) symptoms and is under development for use in pediatric patients. ... -
Pharmacological evaluation of the effects of enzymatically liberated fish oil on eosinophilic inflammation in animal models
(Journal article; Peer reviewed, 2022)The inappropriate activation of eosinophils is a well-recognized driver of various human inflammatory diseases including asthma, chronic rhinitis, and various gastrointestinal diseases, including eosinophilic esophagitis. ... -
Phenotypic spectrum and clinical course of single large-scale mitochondrial DNA deletion disease in the paediatric population: a multicentre study
(Journal article; Peer reviewed, 2023)Background: Large-scale mitochondrial DNA deletions (LMD) are a common genetic cause of mitochondrial disease and give rise to a wide range of clinical features. Lack of longitudinal data means the natural history remains ... -
The phenotypic spectrum of polymerase gamma (POLG) disease from birth to late adulthood
(Doctoral thesis, 2020-09-25)Variants in POLG, the gene encoding the catalytic subunit of DNA-polymerase gamma (polγ), the enzyme that replicates and repairs the mitochondrial genome, are among the most common causes of inherited mitochondrial disease. ... -
Photopic full-field electroretinography and optical coherence tomography in type 1 diabetic retinopathy
(Peer reviewed; Journal article, 2015-07)Purpose: The purpose of this study was to evaluate the role of photopic full-field electroretinography (ERG) and retinal thickness measurements by spectral-domain optical coherence tomography (SD-OCT) in the assessment of ... -
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
(Peer reviewed; Journal article, 2011-11-01)Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies ... -
Physical models for simulation and reconstruction of human tissue deformation fields in dynamic MRI
(Peer reviewed; Journal article, 2016-10)Objective: Medical image registration can be formulated as a tissue deformation problem, where parameter estimation methods are used to obtain the inverse deformation. However, there is limited knowledge about the ability ... -
Physical training and exercise in myasthenia gravis
(Journal article; Peer reviewed, 2021)Myasthenia gravis is characterized by muscle weakness and fatigue. As sustained muscle use increases the weakness, the value of physical training programs has previously been questioned. This is a review to clarify the ... -
Physician participation in quality improvement work- interest and opportunity: a cross-sectional survey
(Journal article; Peer reviewed, 2022-10-25)Background: Lack of physician involvement in quality improvement threatens the success and sustainability of quality improvement measures. It is therefore important to assess physicians´ interests and opportunities to be ... -
Physicians’ use of pain scale and treatment procedures among children and youth in emergency primary care - a cross sectional study
(Peer reviewed; Journal article, 2015-11-06)Background: Pain is a common symptom in children and youth attending casualty centres and emergency departments. The aim of this study was to acquire more knowledge about how pain in children is measured and handled by ... -
A pilot study of angiotensin converting enzyme (ACE) genotype and return of spontaneous circulation following out-of-hospital cardiac arrest
(Peer reviewed; Journal article, 2014-08-14)Objective: In the last few years the genetic influence on health and disease outcome has become more apparent. The ACE genotype appears to play a significant role in the pathophysiology of several disease processes. This ... -
A pilot study of hot-wire, ultrasonic and wedge-bellows spirometer inter- and intra-variability
(Peer reviewed; Journal article, 2017-10-10)Objective: The aim of this pilot study was to compare spirometric values obtained with different types of spirometers, spirometers of same type, and repeated measurements with the same spirometer in a pulmonary function ... -
A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression
(Peer reviewed; Journal article, 2017-03-01)Background: Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studies ... -
Pilot testing of the first version of the European Association for Palliative Care basic dataset: A mixed methods study
(Peer reviewed; Journal article, 2019)Background: Inadequate description of palliative care cancer patients in research studies often leads to results having limited generalizability. To standardize the description of the sample, the European Association for ... -
Placental histology predicted adverse outcomes in extremely premature neonates in Norway-population-based study
(Journal article; Peer reviewed, 2021)Aim We evaluated the role of placental pathology in predicting adverse outcomes for neonates born extremely preterm (EPT) before 28 weeks of gestation. Methods This was a prospective observational study of 123 extremely ... -
Plasma 25 hydroxyvitamin D level and blood gene expression profiles: a cross-sectional study of the Norwegian Women and Cancer Post-genome Cohort
(Journal article; Peer reviewed, 2013)Background/Objectives: Vitamin D deficiency has been associated with increased risk of developing several diseases, but much is unknown about the molecular effects involved. Gene expression technology is increasingly being ... -
Plasma 25-hydroxyvitamin D and mortality in patients with suspected stable angina pectoris
(Peer reviewed; Journal article, 2018-03)Context and Objective: Vitamin D status may affect cardiovascular disease (CVD) development and survival. We studied the relationship between concentrations of the circulating biomarker 25-hydroxyvitamin D (25OHD) and ...