Blar i Department of Clinical Medicine på tittel

Viser treff 1623-1642 av 2043

    • Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma 

      Hugdahl, Emilia Signe; Bachmann, Ingeborg M.; Schuster, Cornelia; Ladstein, Rita Grude; Akslen, Lars A. (Peer reviewed; Journal article, 2019-01-14)
      Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and ...

    • Prognostication after out-of-hospital cardiac arrest, a clinical survey 

      Busch, Michael; Søreide, Eldar (Peer reviewed; Journal article, 2008-09-15)
      Background: Numerous parameters and tests have been proposed for outcome prediction in comatose out-of-hospital cardiac arrest survivors. We conducted a survey of clinical practice of prognostication after therapeutic ...

    • Progressive striatal necrosis associated with anti-NMDA receptor antibodies 

      Tzoulis, Charalampos; Vedeler, Christian A.; Haugen, Mette; Storstein, Anette; Tran, Gia Tuong Thi; Gjerde, Ivar Otto; Biermann, Martin; Schwarzlmüller, Thomas; Bindoff, Laurence (Peer reviewed; Journal article, 2013-05-31)
      Background: We report a case of childhood onset, generalized dystonia due to slowly progressive bilateral striatal necrosis associated with anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. This clinical phenotype has ...

    • Proliferation in operable breast cancer : Aspects of prognostication and relevance of carbohydrate metabolism 

      Lende, Tone Hoel (Doctoral thesis, 2020-03-06)
      Breast cancer is the most common malignant disease among women in the Western world. In Norway and the Netherlands, the incidence has more than doubled in the last 50 years, likely due to increased estrogen exposure, higher ...

    • Proliferation, lymph vessel invasion and histologic type as prognostic factors in lymph node negative breast cancer 

      Gudlaugsson, Einar (Doctoral thesis, 2011-12-14)
      Breast cancer is a leading cause of cancer mortality among women in the western world, second only to lung cancer. Since the mammography screening program in Norway started in 1995, 70% and more of all new breast cancers ...

    • Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation 

      Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Gilja, Odd Helge; Tronstad, Rune Rose; Sangnes, Dag André; Nortvedt, Ragnar; Hausken, Trygve; Dimcevski, Georg Gjorgji; Fiskerstrand, Torunn; Nylund, Kim (Peer reviewed; Journal article, 2017)
      Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ...

    • A proper lookout. Studies of contrast sensitivity 

      Koefoed, Vilhelm F. (Doctoral thesis, 2018-09-14)
      Naval navigation and watch keeping in littoral waters is highly dependent on visual function, and all navigators are required to have normal visual acuity (VA) measured by Snellen’s table or equivalent. Although visual ...

    • Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative 

      Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank (Peer reviewed; Journal article, 2019-09-25)
      Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...

    • A prospective observational study of why people are medically evacuated from offshore installations in the North Sea 

      Waje-Andreassen, Anne; Østerås, Øyvind; Brattebø, Guttorm (Journal article; Peer reviewed, 2020)
      Objectives Few studies have described evacuations due to medical emergencies from the offshore installations in the North Sea, though efficient medical service is essential for the industrial activities in this area. The ...

    • Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Surgical Procedures, Complications, and Postoperative Outcomes 

      Teklemariam, Tsegazeab Laeke; Aklilu, Abenezer Tirsit; Kassahun, Azarias; Sahlu, Abat; Yesehak, Betelehem; Getahun, Samuel; Zenebe, Eyob; Deyassa, Negussie; Moen, Bente Elisabeth; Lund-Johansen, Morten; Sundstrøm, Terje (Journal article; Peer reviewed, 2021)
      Background Traumatic brain injury (TBI) is an important cause of trauma-related mortality and morbidity in Ethiopia. There are significant resource limitations along the entire continuum of care, and little is known about ...

    • Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Trauma Causes, Injury Types, and Clinical Presentation 

      Teklemariam, Tsegazeab Laeke; Aklilu, Abenezer Tirsit; Kassahun, Azarias; Sahlu, Abat; Debebe, Tequam; Yesehak, Betelehem; Masresha, Samuel; Deyassa, Negussie; Moen, Bente Elisabeth; Lund-Johansen, Morten; Sundstrøm, Terje (Journal article; Peer reviewed, 2021)
      Background Traumatic brain injury (TBI) is a public health problem in Ethiopia. More knowledge about the epidemiology and neurosurgical management of TBI patients is needed to identify possible focus areas for quality ...

    • Protein intake in children and growth and risk of overweight or obesity: A systematic review and meta-analysis 

      Arnesen, Erik Kristoffer; Thorisdottir, Birna; Lamberg-Allardt, Christel; Bärebring, Linnea; Nwaru, Bright; Dierkes, Jutta; Ramel, Alfons; Åkesson, Agneta (Journal article; Peer reviewed, 2022)
      Objectives: The aim of this study was to examine the evidence for an association between the dietary protein intake in children and the growth and risk of overweight or obesity up to 18 years of age in settings relevant ...

    • Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats 

      Finne, Kenneth; Vethe, Heidrun; Skogstrand, Trude; Leh, Sabine Maria; Dahl, Tone Dolva; Tenstad, Olav; Berven, Frode S.; Reed, Rolf K.; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2014-08-16)
      Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ...

    • Proteomic analysis of total cellular proteins of human neutrophils 

      Tomazella, Gisele G.; da Silva, Idalete; Laure, Helen J.; Rosa, José C.; Chammas, Roger; Wiker, Harald G.; de Souza, Gustavo A.; Greene, Lewis J. (Peer reviewed; Journal article, 2009-08-31)
      Background: Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...

    • Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease 

      Elsaid, Hassan Osman Alhassan; Rivedal, Mariell Lossius; Skandalou, Eleni; Svarstad, Einar; Tøndel, Camilla; Birkeland, Even; Eikrem, Øystein Solberg; Babickova, Janka; Marti, Hans Peter; Furriol, Jessica (Journal article; Peer reviewed, 2023)
      Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ...

    • Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers 

      Aqrawi, Lara Adnan; Galtung, Hilde; Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Utheim, Tor Paaske; Chen, Xiangjun; Utheim, Øygunn Aass; Palm, Øyvind; Skarstein, Kathrine; Jensen, Janicke Liaaen (Peer reviewed; Journal article, 2019-07-31)
      Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ...

    • Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)
      Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ...

    • Protocol for data extraction: how realworld data have been used in the National Institute for Health and Care Excellence appraisals of cancer therapy 

      Kang, Jiyeon; Cairns, John Alexander (Journal article; Peer reviewed, 2022)
      Introduction Due to the limitations of relying on randomised controlled trials, the potential benefits of real-world data (RWD) in enriching evidence for health technology assessment (HTA) are highlighted. Despite increased ...

    • Proton pump inhibitors in acid-related diseases. Issues in diagnosis, treatment and outcome 

      Jonasson, Christian (Doctoral thesis, 2013-06-18)
      Acid-related disease (ARD) is a term used to describe a range of conditions in which acid is involved in the generation of symptoms and/or complications. Two of the most common ARDs are gastro-esophageal reflux disease ...

    • PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression 

      Sui, Lufei; Wang, Suming; Ganguly, Debolina; El Rayes, Tyler P.; Askeland, Cecilie; Børretzen, Astrid; Sim, Danielle; Halvorsen, Ole Johan; Knutsvik, Gøril; Arnes, Jarle; Aziz, Sura Mohammed; Haukaas, Svein Andreas; Foulkes, William D.; Bielenberg, Diane R.; Ziemys, Arturas; Mittal, Vivek; Brekken, Rolf A.; Akslen, Lars Andreas; Watnick, Randolph (Journal article; Peer reviewed, 2022)
      The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ...