Browsing Department of Clinical Medicine by Title

Now showing items 493-512 of 2029

    • Differences in combinations and concentrations of drugs of abuse in fatal intoxication and driving under the influence cases 

      Edvardsen, Hilde Marie Erøy; Tverborgvik, Torill; Frost, Joachim; Rogde, Sidsel; Morild, Inge; Waal, Helge; Clausen, Thomas; Slørdal, Lars; Vindenes, Vigdis (Peer reviewed; Journal article, 2017-12)
      Background: In toxicology, international classification systems focus on single intoxicants as the cause of death. It is, however, well known that very few drug related deaths are caused by a single substance and that ...

    • Differences in mortality in critically ill elderly patients during the second COVID‑19 surge in Europe 

      Jung, Christian; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolf, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans (Journal article; Peer reviewed, 2021)
      Background: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. Methods: This was a prospective European ...

    • Differences in nutrient and undesirable substance concentrations in Maurolicus muelleri across the Bay of Biscay, Norwegian fjords, and the North Sea 

      Zhu, Yiou; Mahjour Azad, Atabak; Kjellevold, Marian; Bald, Carlos; Iñarra, Bruno; Alvarez, Paula; Boyra, Guillermo; Berntssen, Marc HG; Madsen, Lise; Wiech, Martin (Journal article; Peer reviewed, 2023)
      Introduction: We are having pressing issues of global food insecurity and malnutrition. Mesopelagic communities in the North Atlantic have been estimated to have high biomasses of organisms. Some of these low-trophic ...

    • Differences in sleep patterns between patients with anorexia nervosa and healthy controls: a cross-sectional study 

      Kleppe, Malin Mandelid; Kessler, Ute; Rekkedal, Guro Årdal; Skjåkødegård, Hanna Flækøy; Danielsen, Yngvild Sørebø (Journal article; Peer reviewed, 2023)
      Background Sleep difficulties are common in patients with anorexia nervosa (AN), but objective assessments have mostly been performed in hospital and laboratory settings. We aimed to identify differences in sleep patterns ...

    • Different approaches to Imaging Mass Cytometry data analysis 

      Milosevic, Vladan (Journal article; Peer reviewed, 2023)
      Imaging Mass Cytometry (IMC) is a novel, high multiplexing imaging platform capable of simultaneously detecting and visualizing up to 40 different protein targets. It is a strong asset available for in-depth study of ...

    • Different Dietary Ratios of Camelina Oil to Sandeel Oil Influence the Capacity to Synthesise and Deposit EPA and DHA in Zucker Fa/Fa Rats 

      Østbye, Tone-Kari K; Gudbrandsen, Oddrun Anita; Drotningsvik, Aslaug; Ruyter, Bente Synnøve; Berge, Gerd Marit; Vogt, Kjell Gjermund; Nilsson, Astrid (Journal article; Peer reviewed, 2023-05-17)
      Plant-based food provides more ALA (α-linolenic acid) and less EPA (eicosapentaenoic acid) and DHA (docosahexanoic acid) than marine food. Earlier studies indicate that cetoleic acid (22:1n-11) stimulates the n-3 pathway ...

    • Differential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trial 

      Sinkeviciute, Igne; Hugdahl, Kenneth Jan; Bartz-Johannessen, Christoffer; Kroken, Rune Andreas; Løberg, Else-Marie; Kjelby, Eirik; Rettenbacher, maria; Joa, Inge; Reitan, Solveig Merete Klæbo; Alisauskiene, Renata; Fathian, Farivar; Johnsen, Erik (Journal article; Peer reviewed, 2021-07)
      Background Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in ...

    • Differential transcript usage in the Parkinson’s disease brain 

      Dick, Fiona; Sanchez Nido, Gonzalo; Alves, Guido Werner; Tysnes, Ole-Bjørn; Nilsen, Gry Hilde; Dölle, Christian; Tzoulis, Charalampos (Peer reviewed; Journal article, 2020)
      Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ...

    • Differentiating traits and states identifies the importance of chronic neuropsychiatric symptoms for cognitive prognosis in mild dementia 

      Melvær, Giil Lasse; Aarsland, Dag; Vik-Mo, Audun Osland (Journal article; Peer reviewed, 2021)
      Introduction Neuropsychiatric symptoms (NPS) in dementia are associated with poor cognitive outcomes in longitudinal studies. Whether this is due to differences in symptom burden between persons (BP) or changes within ...

    • Difficult birth is the main contributor to birth‐related fracture and accidents to other neonatal fractures 

      Högberg, Ulf; Fellman, Vineta; Thiblin, Ingemar; Karlsson, Ruth; Wester, Knut (Journal article; Peer reviewed, 2020)
      Aim Specific birth-related fractures have been studied; underestimates might be a problem. We aimed to assess all fractures diagnosed as birth-related as well as other neonatal fractures. Methods A population-based ...

    • Digital Breast Tomosynthesis : - the future screening tool for breast cancer? 

      Aase, Hildegunn Siv (Doctoral thesis, 2022-10-31)
      Bakgrunn: Brystkreft er den vanligste kreftformen blant kvinner og en av de hyppigste årsakene til kreftdødsfall i Norge og globalt. Målsettingen med mammografiscreening er å oppdage brystkreft i et tidlig stadium og ...

    • Digital Image Analysis of the Proliferation Markers Ki67 and Phosphohistone H3 in Gastroenteropancreatic Neuroendocrine Neoplasms: Accuracy of Grading Compared with Routine Manual Hot Spot Evaluation of the Ki67 Index 

      Lea, Dordi; Gudlaugsson, Einar G.; Skaland, Ivar; Lillesand, Melinda; Søreide, Kjetil; Søreide, Jon A. (Journal article; Peer reviewed, 2021)
      Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare epithelial neoplasms. Grading is based on mitotic activity or the percentage of Ki67-positive cells in a hot spot. Routine methods have poor intraobserver ...

    • Disc and nerve root findings on lumbar MRI with straightened vs flexed hips and knees—pilot study 

      Espeland, Ansgar; Seime, Nina Dalen (Journal article, 2019)
      Objective: To compare disc and nerve root findings, image quality, and pain between supine lumbar MRI positions with straightened vs flexed hips and knees. Methods: In this prospective pilot study, 14 adults with sciatica ...

    • Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM 

      Kroksveen, Ann Cathrine; Aasebø, Elise; Vethe, Heidrun; van Pesch, Vincent; Franciotta, Diego; Teunissen, Charlotte E.; Ulvik, Rune Johan; Vedeler, Christian A.; Myhr, Kjell-Morten; Barsnes, Harald; Berven, Frode (Peer reviewed; Journal article, 2013-01)
      In the present study, we aimed to discover cerebrospinal fluid (CSF) proteins with significant abundance difference between early multiple sclerosis patients and controls, and do an initial verification of these proteins ...

    • Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies 

      Uleberg, Kai-Erik; Munk, Ane Cecilie; Brede, Cato; Gudlaugsson, Einar; Diermen, Bianca van; Skaland, Ivar; Malpica, Anais; Janssen, Emilius Adrianus Maria; Hjelle, Anne; Baak, Jan P. A. (Peer reviewed; Journal article, 2011-06-28)
      Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as “high grade”, in spite of their different risk to cancer progression and spontaneous regression rates. ...

    • Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies 

      Pörksen, Sven; Laborie, Lene Bjerke; Nielsen, Lotte; Andersen, Marie Louise Max; Sandal, Tone; de Wet, Heidi; Schwarcz, Erik; Åman, Jan; Swift, Peter; Kocova, Mirjana; Schönle, Eugen J.; de Beaufort, Carine; Hougaard, Philip; Ashcroft, Frances; Molven, Anders; Knip, Mikael; Mortensen, Henrik B.; Hansen, Lars; Njølstad, Pål Rasmus; Hvidøre Study Group on Childhood Diabetes (Peer reviewed; Journal article, 2010-09-23)
      Background: To investigate disease progression the first 12 months after diagnosis in children with type 1 diabetes negative (AAB negative) for pancreatic autoantibodies [islet cell autoantibodies(ICA), glutamic acid ...

    • Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 

      Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter V.; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Osmani, Venet (Journal article; Peer reviewed, 2022)
      Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...

    • Disease-modifying treatments for multiple sclerosis – a review of approved medications 

      Torkildsen, Øivind; Myhr, Kjell-Morten; Bø, Lars (Peer reviewed; Journal article, 2015-11-13)
      Background and purpose: There is still no curative treatment for multiple sclerosis (MS), but during the last 20 years eight different disease-modifying compounds have been approved for relapsing remitting MS (RRMS). ...

    • Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations 

      Liang, Xiao; Kristiansen, Cecilie Katrin; Mostafavi, Sepideh; Vatne, Guro H.; Zantingh, Gina; Kianian, Atefeh; Tzoulis, Charalampos; Høyland, Lena Elise; Ziegler, Mathias; Perez, Roberto Megias; Furriol, Jessica; Zhang, Zhuoyuan; Balafkan, Novin; Hong, Yu; Siller, Richard; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)
      Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using ...

    • Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools 

      Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin S; Frei, Oleksandr; Shadrin, Alexey; Cheng, Weiqiu; Bettella, Francesco; Rødevand, Linn; Ødegaard, Ketil Joachim; Fan, Chun C; Pirinen, Matti J; Hautakangas, Heidi M; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Tronvik, Erling Andreas; Kristoffersen, Espen Saxhaug; Zwart, John Anker Henrik; Nielsen, Jonas Bille; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Stovner, Lars Jacob; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Lie, Marie; Holmen, Oddgeir Lingaas; Børte, Sigrid; Stensland, Synne; Zhou, Wei; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are ...