Blar i Department of Clinical Medicine på tittel
Viser treff 807-826 av 2034
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From archival tissues to systems biology: Using transcriptomics to investigate the progression of kidney disease
(Doctoral thesis, 2023-03-13)Innledning: Både nyrecellekarsinom og Fabrys sykdom påvirker nyrene på en progressiv måte. Gjennom bruk av RNA-sekvenserings teknologi kan man predikere og øke forståelsen av de ulike mekanismene som driver denne ... -
From hearing to seeing: medical dispatchers' experience with use of video streaming in medical emergency calls - a qualitative study
(Journal article; Peer reviewed, 2022)Objectives: Video streaming has recently been introduced as an additional tool for communication between medical dispatchers and caller. Research implies that video streaming may be a useful tool for the dispatchers, but ... -
FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life: A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
(Journal article; Peer reviewed, 2011-05)OBJECTIVE—FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult ... -
Functional and animal studies of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a fatty acid beta-oxidation enzyme involved in congenital hyperinsulinism of infancy
(Doctoral thesis, 2021-02-16)Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a mitochondrial enzyme involved in fatty acid β-oxidation and the regulation of β-cell insulin secretion. Its role in insulin secretion became apparent in 2001 when ... -
Functional and Prognostic Role of MicroRNAs in Cancer Associated Fibroblasts and Stroma in Oral Squamous Cell Carcinoma
(Doctoral thesis, 2023-11-23)Nyere studier har vist at forandringer i bindevevscellene som omgir kreftsvulsten er viktige for utviklingen av munnhulekreft. Kreft stroma kan regulere fenotypen av kreftcellene, og på den måten kan påvirke klinisk forløpet ... -
Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID)
(Journal article; Peer reviewed, 2023)All-trans retinoic acid-induced differentiation (ATRAID) factor was first identified in HL60 cells. Several mRNA isoforms exist, but the respective proteins have not been fully characterized. In transfected cells expressing ... -
Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro
(Journal article; Peer reviewed, 2021)Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ... -
Functional Gastrointestinal Disorders following Giardia infection : Visceral hypersensitivity and low-grade inflammation
(Doctoral thesis, 2020-10-20)Background: Giardia lamblia is a non-invasive protozoan parasite, infecting mainly the upper small intestine. It is the most common cause of waterborne outbreaks of diarrhea in an endemic country. The first registered ... -
Functional imaging to promote individualized and targeted therapy in endometrial cancer
(Doctoral thesis, 2016-02-05)Background: Endometrial carcinoma is the most common pelvic malignancy in the Western world and the incidence is increasing. Endometrial carcinomas are surgically staged according to FIGO 2009 criteria, and the lack of ... -
Functional level after Traumatic Brain Injury
(Doctoral thesis, 2012-02-03)Objectives: The objectives of the thesis were to describe the functional level (papers I and II) and self awareness of functional deficits (paper III) after moderate and severe Traumatic Brain Injury (TBI), and to evaluate ... -
Functional Level During the First Year After Moderate and Severe Traumatic Brain Injury: Course and Predictors of Outcome
(Peer reviewed; Journal article, 2011-06)Background: The objective of this study was to describe the functional level during the first year after moderate and severe traumatic brain injury (TBI), and to evaluate the predictive impact of pre-injury and injury-related ... -
Functional MRI, structural MRI and school performance in extremely preterm/extremely low birth weight children
(Doctoral thesis, 2013-11-22)Purpose: Numbers of extremely preterm (EPT) children who survive is steadily increasing, and the majority of these children are in need of help at school. The purpose of this regional, clinical controlled cohort study was ... -
Functional outcomes associated with varying levels of targeted temperature management after out-of-hospital cardiac arrest ? An INTCAR2 registry analysis
(Peer reviewed; Journal article, 2020)Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival ... -
G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis
(Peer reviewed; Journal article, 2018-09-17)We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally ... -
Gastric adenocarcinoma: aspects of development and progression in high- and low-risk countries
(Doctoral thesis, 2010-03-25) -
Gastric diverticulum and halitosis - A case for surgery?
(Peer reviewed; Journal article, 2014-05-09)INTRODUCTION Gastric diverticulum is a rare and frequently asymptomatic condition. Symptoms include vague pain, fullness, dyspepsia, vomiting, hemorrhage and perforation. Occasionally, the patient can present with belching ... -
Gastric dysmotility and visceral hypersensitivity – an ultrasound approach to functional GI disorders and diabetic gastroparesis
(Doctoral thesis, 2021-09-24)Background: Functional dyspepsia (FD), irritable bowel syndrome (IBS) and diabetic gastroparesis (DG) are conditions with overlapping symptoms and motility characteristics. The objective of this dissertation was to investigate ... -
Gastric emptying of low- and high-caloric liquid meals measured using ultrasonography in healthy volunteers
(Peer reviewed; Journal article, 2019-01-07)Purpose Delayed gastric emptying is present in patients with functional dyspepsia (FD), diabetes mellitus, and neurological diseases. Diet may affect gastric emptying symptoms in patients with FD. We sought to determine ... -
Gastric function in diabetic gastroparesis assessed by ultrasound and scintigraphy
(Journal article; Peer reviewed, 2021)Background: Gastroparesis is a severe diabetes complication characterized by delayed gastric emptying. We examined patients with symptoms of diabetic gastroparesis using gastric emptying scintigraphy and ultrasound drink ... -
Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls
(Journal article; Peer reviewed, 2021)Background: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better ...