Browsing Department of Clinical Medicine by Title
Now showing items 912-931 of 1371
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Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models
(Peer reviewed; Journal article, 2016)BACKGROUND: Oral cavity is a doorway for a variety of products containing titanium dioxide (TiO2) nanoparticles (NPs) (nano-TiO2) such as food additives, oral healthcare products and dental materials. Their potential to ... -
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes
(Peer reviewed; Journal article, 2016-07)This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance ... -
National Norwegian Practice Patterns for Surgical Treatment of Kidney Cancer Tumors ≤7 cm: Adherence to Changes in Guidelines May Improve Overall Survival
(Peer reviewed; Journal article, 2018-08)Background: Guidelines on surgical treatment for kidney cancer (KC) have changed over the last 10 yr. We present population-based data for patients with KC tumors ≤7 cm from 2008 to 2013 to investigate whether surgical ... -
Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis
(Journal article; Peer reviewed, 2020-04-30)Background: High serum levels of 25-hydroxyvitamin D (25(OH)D) have been found among patients with a favorable disease course in relapsing-remitting MS (RRMS), indicating that this may limit clinical deterioration. Clinical ... -
A Naturalistic Study of the Effect of Acupuncture on Heart-Rate Variability
(Peer reviewed; Journal article, 2012-02)Objectives: To study the effect of acupuncture on heart rate variability (HRV) by using linear and non-linear methods of analysis. Methods: 40 patients were recruited consecutively, including patients with insomnia, ... -
Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia
(Peer reviewed; Journal article, 2018-04)Background In achalasia, muscle spasm may involve the proximal esophagus. When the muscle spasm is located in the proximal esophagus, conventional per oral endoscopic myotomy (POEM) may not be sufficient to relieve symptoms. ... -
Neck pain associated with clinical symptoms in dizzy patients- A cross-sectional study
(Peer reviewed; Journal article, 2020)Objective: Many patients suffer from concurrent neck pain and dizziness. The aim of this study was to describe the clinical symptoms and physical findings in patients with concurrent neck pain and dizziness and to examine ... -
Negotiating the boundaries of psychosis: A qualitative studyof the service provider perspective on treatment delay incommunity mental health
(Peer reviewed; Journal article, 2017)Aim: Evidence shows that many patients are detected and treated late in their course of illness, and that substantial delay occurs even after entry to mental health services. Although several studies have examined the ... -
Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial
(Peer reviewed; Journal article, 2017-08-25)Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ... -
Neuroborreliosis in children: Epidemiological and clinical aspects
(Doctoral thesis, 2012-06-08)Background: Lyme borreliosis (LB) caused by the bacteria Borrelia burgdorferi sensu lato (Bbsl) is the most common tick transmitted infection in Europe. LB is a multi systemic infection that develops when the bacteria ... -
Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression
(Peer reviewed; Journal article, 2013-04-04)Background: The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD ... -
Neurofeedback for the treatment of children and adolescents with ADHD: a randomized and controlled clinical trial using parental reports
(Peer reviewed; Journal article, 2012-08-10)Background: A randomized and controlled clinical study was performed to evaluate the use of neurofeedback (NF) to treat attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. Methods: The ADHD population ... -
Neurofilament light chain as a biomarker in multiple sclerosis
(Peer reviewed; Journal article, 2019-04-05)Due to the unpredictable course and heterogenous treatment response in multiple sclerosis (MS), there is a clear need for biomarkers that reflect disease activity in the clinical follow-up of these patients. Neurofilaments ... -
Neurofilament light chain predicts disease activity in relapsing-remitting MS
(Peer reviewed; Journal article, 2018)Objective: To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods: A cohort of 85 patients with RRMS were followed ... -
Neuroleptic malignant syndrome: An easily overlooked neurologic emergency
(Peer reviewed; Journal article, 2017-01-16)Neuroleptic malignant syndrome is an unpredictable iatrogenic neurologic emergency condition, mainly arising as an idiosyncratic reaction to antipsychotic agent use. It is characterized by distinctive clinical features ... -
Neuropsychological assessment of cognitive and emotional functioning in patients with epilepsy
(Doctoral thesis, 2006-08-17)The general aim of the thesis has been to contribute to a deeper understanding of central psychosocial and cognitive problems experienced by patients with epilepsy. In the first paper, the aim was to evaluate the impact ... -
New methods clear the dust off old biopsies. RNA sequencing of FFPE kidney biopsies
(Doctoral thesis, 2019-06-07)Background and aims: Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. We wanted to exploit renal biopsies also on the mRNA level to elucidate pathophysiological mechanisms ... -
A New Score for Sharp Discharges in the EEG Predicts Epilepsy
(Journal article; Peer reviewed, 2021)Purpose: A challenge in EEG interpretation is to correctly classify suspicious focal sharp activity as epileptiform or not. A predictive score was developed from morphologic features of the first focal sharp discharge, ... -
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
(Journal article; Peer reviewed, 2021)Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria ... -
No association of tobacco use and disease activity in multiple sclerosis
(Peer reviewed; Journal article, 2016-08)Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally ...