Blar i Department of Clinical Medicine på forfatter "Kalland, Karl-Henning"
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Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation
Ke, Xi-Song; Qu, Yi; Goldfinger, Naomi; Rostad, Kari; Hovland, Randi; Akslen, Lars A.; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning (Peer reviewed; Journal article, 2008-10-13)Background: Epithelial to mesenchymal transition (EMT) has been connected with cancer progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has been induced in prostate cancer cell lines, ... -
Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia
Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem; Stordrange, Laila; Jonassen, Inge; Bruserud, Øystein; Kalland, Karl-Henning; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-03-05)Background: The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect ... -
Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells
Ke, Xi-Song; Qu, Yi; Cheng, Yang; Li, Wen-Cheng; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning (Peer reviewed; Journal article, 2010-11-25)Background: Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA ... -
High-Throughput Mutation Profiling of Primary and Metastatic Endometrial Cancers Identifies KRAS, FGFR2 and PIK3CA to Be Frequently Mutated
Krakstad, Camilla; Birkeland, Even; Seidel, Danila; Kusonmano, Kanthida; Petersen, Kjell; Mjøs, Siv; Høivik, Erling Andre; Wik, Elisabeth; Halle, Mari Kyllesø; Øyan, Anne Margrete; Kalland, Karl-Henning; Werner, Henrica Maria Johanna; Trovik, Jone; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012-12-27)Background: Despite being the most common pelvic gynecologic malignancy in industrialized countries, no targeted therapies are available for patients with metastatic endometrial carcinoma. In order to improve treatment, ... -
Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers
Ræder, Maria B.; Birkeland, Even; Trovik, Jone; Krakstad, Camilla; Shehata, Shyemaa; Schumacher, Steven; Zack, Travis I.; Krohn, Antje; Werner, Henrica Maria Johanna; Moody, Susan E.; Wik, Elisabeth; Stefansson, Ingunn; Holst, Frederik; Øyan, Anne Margrete; Tamayo, Pablo; Mesirov, Jill P.; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Beroukhim, Rameen; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2013-02-05)Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most ... -
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B.; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012)BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma ... -
Lipocalin 2 expression is associated with aggressive features of endometrial cancer
Mannelqvist, Monica; Stefansson, Ingunn; Wik, Elisabeth; Kusonmano, Kanthida; Ræder, Maria B.; Øyan, Anne Margrete; Kalland, Karl-Henning; Moses, Marsha A.; Salvesen, Helga Birgitte; Akslen, Lars A. (Peer reviewed; Journal article, 2012-05-06)Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ...