Blar i Department of Clinical Medicine på forfatter "el Jellas, Khadija"

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    • Associations between ABO blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival 

      el Jellas, Khadija; Hoem, Dag; Hagen, Kristin Gjerde; Kalvenes, May Britt; Aziz, Sura Mohammed; Steine, Solrun; Immervoll, Heike; Johansson, Stefan; Molven, Anders (Peer reviewed; Journal article, 2017-07)
      Both serology‐based and genetic studies have reported an association between pancreatic cancer risk and ABO blood groups. We have investigated this relationship in a cohort of pancreatic cancer patients from Western Norway ...

    • Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia 

      St-Louis, Johanna L.; el Jellas, Khadija; Velasco, Kelly; Slipp, Brittany A.; Hu, Jiang; Helgeland, Geir; Steine, Solrun; De Jesus, Dario F.; Kulkarni, Rohit N.; Molven, Anders (Journal article; Peer reviewed, 2023)
      Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). To test the hypothesis that SCHAD-CHI arises from a specific ...

    • The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice 

      Fjeld, Karianne; Svanbring, Anny Gravdal; Brekke, Ranveig Seim; Alam, Jahedul; Wilhelm, Steven J.; el Jellas, Khadija; Pettersen, Helene Nazmiye; Lin, Jianguo; Solheim, Marie Holm; Steine, Solrun; Johansson, Bente Berg; Njølstad, Pål Rasmus; Verbeke, Caroline Sophie; Xiao, Xunjun; Lowe, Mark E.; Molven, Anders (Journal article; Peer reviewed, 2022)
      Background & aims: The CEL gene encodes the digestive enzyme carboxyl ester lipase. CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant suggested to increase the risk of chronic pancreatitis ...

    • Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma 

      Choi, Man Hung; Mejlænder-Andersen, Eline; Manueldas, Sophia; el Jellas, Khadija; Steine, Solrun; Tjensvoll, Kjersti; Sætran, Hege Aase; Knappskog, Stian; Hoem, Dag; Nordgård, Oddmund; Hovland, Randi; Molven, Anders (Peer reviewed; Journal article, 2019-01-05)
      Background Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ...

    • Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells 

      Valvatne, Monica Dalva; el Jellas, Khadija; Gravdal, Anny; Njølstad, Pål Rasmus; Molven, Anders; Fjeld, Karianne; Lugea, Aurelia; Pandol, Stephen J; Waldron, Richard T; Lavik, Ida; Johansson, Bente B. (Journal article; Peer reviewed, 2020)
      Mutations in the gene encoding the digestive enzyme carboxyl ester lipase (CEL) are linked to pancreatic disease. The CEL variant denoted CEL-HYB predisposes to chronic pancreatitis, whereas the CEL-MODY variant causes ...