• The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19 

      Bruno, Raphael Romano; Wernly, Bernhard; Flaatten, Hans Kristian; Fjølner, Jesper; Artigas, Antonio; Baldia, Philipp Heinrich; Binneboessel, Stephan; Bollen Pinto, Bernardo; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Wollborn, Jakob; Andersen, Finn Husøy; Moreno, Emilio Ruiz; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Jung, Christian (Journal article; Peer reviewed, 2022)
      Purpose Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities ...
    • The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data 

      Bruno, Raphael Romano; Wernly, Bernhard; Bagshaw, Sean M.; van den Boogaard, Mark; Darvall, Jai N.; De Geer, Lina; de Gopegui Miguelena, Pablo Ruiz; Heyland, Daren K.; Hewitt, David; Hope, Aluko A.; Langlais, Emilie; Le Maguet, Pascale; Montgomery, Carmel L.; Papageorgiou, Dimitrios; Seguin, Philippe; Geense, Wytske W.; Silva-Obregón, J. Alberto; Wolff, Georg; Polzin, Amin; Dannenberg, Lisa; Kelm, Malte; Flaatten, Hans Kristian; Beil, Michael; Franz, Marcus; Sviri, Sigal; Leaver, Susannah; Guidet, Bertrand; Boumendil, Ariane; Jung, Christian (Journal article; Peer reviewed, 2023)
      Background This large-scale analysis pools individual data about the Clinical Frailty Scale (CFS) to predict outcome in the intensive care unit (ICU). Methods A systematic search identified all clinical trials that ...
    • Frailty’s influence on 30-day mortality in old critically ill ICU patients: a bayesian analysis evaluating the clinical frailty scale 

      Wernly, Bernhard; Bruno, Raphael Romano; Beil, Michael; Flaatten, Hans Kristian; Kelm, Malte; Sigal, Sviri; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Koköfer, Andreas; Oeyen, Sandra; Marsh, Brian; Moreno, Rui; Wernly, Sarah; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Jung, Christian (Journal article; Peer reviewed, 2023)
      Introduction Frailty is widely acknowledged as influencing health outcomes among critically ill old patients. Yet, the traditional understanding of its impact has predominantly been through frequentist statistics. We ...
    • The impact of age-related syndromes on ICU process and outcomes in very old patients 

      Vallet, Hélène; Guidet, Bertrand; Boumendil, Ariane; De Lange, Dylan W.; Leaver, Susannah; Szczeklik, Wojciech; Jung, Christian; Sviri, Sigal; Beil, Michael; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2023)
      In this narrative review, we describe the most important age-related “syndromes” found in the old ICU patients. The syndromes are frailty, comorbidity, cognitive decline, malnutrition, sarcopenia, loss of functional autonomy, ...
    • Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients 

      Bruno, Raphael Romano; Wernley, Bernhard; Flaatten, Hans; Fjølner, Jesper; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Binnebössel, Stephan; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sigal, Sivri; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Wollborn, Jakob; Banzo, Maria José Arche; Fuest, Kristina; Marsh, Brian; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Jung, Christian (Journal article; Peer reviewed, 2021)
      Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have ...
    • Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic 

      Polok, Kamil; Fronczek, Jakub; Guidet, Bertrand; Artigas, Antonio; De Lange, Dylan W.; Fjølner, Jesper; Leaver, Susannah; Beil, Michael; Sviri, Sigal; Bruno, Raphael Romano; Wernly, Bernhard; Pinto, Bernardo Bollen; Schefold, Joerg C.; Studzińska, Dorota; Joannidis, Michael; Oeyen, Sandra; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Flaatten, Hans Kristian; Jung, Christian; Szczeklik, Wojciech (Journal article; Peer reviewed, 2023)
      Background Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and ...
    • Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study 

      Flaatten, Hans; Guidet, Bertrand; Andersen, Finn Husøy; Artigas, Antonio; Cecconi, Maurizio; Boumendil, Ariane; Elhadi, Muhammed; Fjølner, Jesper; Joannidis, Michael; Jung, Christian; Leaver, Susannah; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Nalapko, Yuriy; Schefold, Joerg C.; Szczeklik, Wojciech; Walther, Sten; Watson, Ximena; Zafeiridis, Tilemachos; de Lange, Dylan W. (Journal article; Peer reviewed, 2021)
      Purpose Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments developed ...
    • Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study 

      Ibarz, Mercedes; Boumendil, Ariane; Flaatten, Hans; Andersen, Finn Husøy; Artigas, Antonio; Haas, Lenneke E. M.; Irazabal, Marian; de Lange, Dylan W.; Morandi, Alessandro; Bertolini, Guido; Cecconi, Maurizio; Christensen, Stefen; Faraldi, Loredana; Fjølner, Jesper; Jung, Christian; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Pinto, Bernardo Bollen; Soliman, Ivo W.; Valentin, Andreas; Szczeklik, Wojciech; Watson, Ximena; Zaferidis, Tilemachos; Guidet, Bertrand; Artigas, Antonio (Journal article; Peer reviewed, 2020)
      Background The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. ...
    • Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study 

      Polok, Kamil; Fronczek, Jakub; Putowski, Zbigniew; Czok, Marcelina; Guidet, Bertrand; Jung, Christian; de Lange, Dylan; Leaver, Susannah; Moreno, Rui; Flaatten, Hans Kristian; Szczeklik, Wojciech (Journal article; Peer reviewed, 2023)
      Background Little is known about the performance of the Sequential Organ Failure Assessment (SOFA) score in older critically ill adults. We aimed to evaluate the prognostic impact of physiological disturbances in the ...