Blar i Department of Clinical Medicine på tidsskrift "PLoS ONE"
Viser treff 1-20 av 36
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An 18-Gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer
(Peer reviewed; Journal article, 2014-06-06)Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. ... -
Actigraphic assessment of motor activity in acutely admitted inpatients with bipolar disorder
(Peer reviewed; Journal article, 2014-02-20)Introduction: Mania is associated with increased activity, whereas psychomotor retardation is often found in bipolar depression. Actigraphy is a promising tool for monitoring phase shifts and changes following treatment ... -
The Association Between Exposure to Interferon-Beta During Pregnancy and Birth Measurements in Offspring of Women With Multiple Sclerosis
(Peer reviewed; Journal article, 2019-12-30)Background: Interferon-beta (IFN-beta) is a commonly used treatment for multiple sclerosis (MS). Current guidelines recommend cessation of treatment during pregnancy, however the results of past studies on the safety of ... -
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
(Peer reviewed; Journal article, 2017-07-31)The pan lymphocyte marker CD45 exists in various isoforms arising from alternative splicing of the exons 4, 5 and 6. While naïve T cells express CD45RA translated from an mRNA containing exon 4, exons 4–6 are spliced out ... -
Comparison of CpG Island Methylator Phenotype (CIMP) Frequency in Colon Cancer Using Different Probe- and Gene-Specific Scoring Alternatives on Recommended Multi-Gene Panels
(Peer reviewed; Journal article, 2014-01-21)Background: In colorectal cancer a distinct subgroup of tumours demonstrate the CpG island methylator phenotype (CIMP). However, a consensus of how to score CIMP is not reached, and variation in definition may influence ... -
Cytokine Patterns in Tuberculosis Infection; IL-1ra, IL-2 and IP-10 Differentiate Borderline QuantiFERON-TB Samples from Uninfected Controls
(Peer reviewed; Journal article, 2016-09-29)Background: Interferon gamma release assays (IGRAs) do not discriminate between active tuberculosis (TB) and latent TB infection (LTBI), which limit their use in TB endemic areas. Subjects with QuantiFERON-TB (QFT) results ... -
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Peer reviewed; Journal article, 2014-02-19)Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ... -
Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells
(Peer reviewed; Journal article, 2019)Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are ... -
Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography
(Peer reviewed; Journal article, 2018-09-27)Extracellular vesicles (EVs) are a heterogeneous population of biological particles released by cells. They represent an attractive source of potential biomarkers for early detection of diseases such as cancer. However, ... -
Employment among patients with multiple sclerosis - A population study
(Peer reviewed; Journal article, 2014-07-23) -
Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation
(Peer reviewed; Journal article, 2008-10-13)Background: Epithelial to mesenchymal transition (EMT) has been connected with cancer progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has been induced in prostate cancer cell lines, ... -
Evaluation of Ki67 expression across distinct categories of breast cancer specimens: A Population-based study of matched surgical specimens, core needle biopsies and tissue microarrays
(Peer reviewed; Journal article, 2014-11-06)Introduction: Tumor cell proliferation in breast cancer is strongly prognostic and may also predict response to chemotherapy. However, there is no consensus on counting areas or cut-off values for patient stratification. ... -
Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study
(Journal article, 2016-05-11)The aim of this study was to identify potential predictive biomarkers in 35 patients with metastatic melanoma treated with anti-angiogenic bevacizumab monotherapy in a clinical phase II study. The immunohistochemical ... -
A family history of stroke is associated with increased intima-media thickness in young ischemic Stroke - The norwegian stroke in the young study (NOR-SYS)
(Peer reviewed; Journal article, 2016-08-09)Background and Purpose: Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral ... -
Fecal fat analyses in chronic pancreatitis importance of fat ingestion before stool collection
(Peer reviewed; Journal article, 2017-01-17)Objective: Quantitative determination of fecal fat still is the gold standard for measuring malabsorption. We evaluated the importance of standardized food intake before and under the collection of feces. Material and ... -
GBA2 mutations cause a Marinesco-Sjogren-like syndrome: Genetic and biochemical studies
(Peer reviewed; Journal article, 2017-01-04)Background: With the advent new sequencing technologies, we now have the tools to understand the phenotypic diversity and the common occurrence of phenocopies. We used these techniques to investigate two Norwegian families ... -
In vitro-stimulated IL-6 monocyte secretion and in vivo peripheral blood T lymphocyte activation uniquely predicted 15-year survival in patients with head and neck squamous cell carcinoma
(Peer reviewed; Journal article, 2015-06-16)The study was performed in order to determine whether peripheral blood monocyte in vitro function, and lymphocyte in vivo activation at diagnosis, was associated with HPV tumor infection status and 15-year survival in head ... -
Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity
(Peer reviewed; Journal article, 2013-09-19)Background. Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore the ... -
Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers
(Peer reviewed; Journal article, 2013-02-05)Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most ... -
Interstitial Fluid Colloid Osmotic Pressure in Healthy Children
(Peer reviewed; Journal article, 2015-04-08)Objective: The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been ...