Blar i Department of Clinical Medicine på emneord "VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762"
Viser treff 1-15 av 15
-
Alterations of the retinoblastoma gene in metastatic breast cancer
(Peer reviewed; Journal article, 2011-01-21)Germline mutations affecting the retinoblastoma gene (RB1) predispose to inherited retinoblastomas but also other malignancies, including breast cancer. While somatic RB1 mutations have been detected in different malignancies, ... -
Benefit from B-Lymphocyte Depletion Using the Anti- CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study
(Peer reviewed; Journal article, 2011-10-19)Background: Chronic fatigue syndrome (CFS) is a disease of unknown aetiology. Major CFS symptom relief during cancer chemotherapy in a patient with synchronous CFS and lymphoma spurred a pilot study of B-lymphocyte depletion ... -
Burkitt Lymphoma in Uganda. A study of some biological and epidemiological aspects of endemic Burkitt lymphoma
(Doctoral thesis, 2011-08-25) -
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers
(Peer reviewed; Journal article, 2010-09)Background: Reported prevalence, penetrance and expression of deleterious mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 and PMS2, may reflect differences in the clinical criteria used to select families ... -
Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies
(Peer reviewed; Journal article, 2011-06-28)Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as “high grade”, in spite of their different risk to cancer progression and spontaneous regression rates. ... -
Endometrial carcinoma; can biomarkers aid in the prediction of aggressive disease? A study with focus on preoperative tumour markers
(Doctoral thesis, 2012-05-04)Background: Although endometrial cancer in general has a good prognosis, 15-20% recurs. Surgery is the main treatment with lymph node sampling increasingly advocated as compulsory for adequate staging. In metastatic disease, ... -
Extra-colonic cancers in Lynch Syndrome
(Doctoral thesis, 2010-11-12)Lynch Syndrome (LS) is the most common of the hereditary colorectal cancer (CRC) syndromes. It is caused by germ-line mutations in one of the four mismatch repair (MMR) genes MLHl, MSH2, MSH6 or PMS2. Mutations in one of ... -
Gene signatures and prognostic factors in endometrial cancer. A study with special focus on vascular invasion
(Doctoral thesis, 2011-04-15) -
Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
(Peer reviewed; Journal article, 2011-01-05)Background: Design of tumour specific immunotherapies using the patients’ own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today’s gold ... -
Onconeural antibodies with special reference to anti-Yo
(Doctoral thesis, 2011-12-20)The mechanisms behind anti-Yo mediated paraneoplastic cerebellar degeneration is still not understood, and very little is known about the function of CDR2. In our studies we have tried to elucidate the properties of Yo ... -
Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age
(Peer reviewed; Journal article, 2011-05-12)Background A national surveillance program of colon cancer treatment was introduced in 2007. We examined prognostic factors for colon cancer operated in 2000 with an aim of improving survival in the new program and a special ... -
Patient-reported outcomes in palliative gastrointestinal stenting: a Norwegian multicenter study
(Peer reviewed; Journal article, 2011-04-13)Background The clinical effect of stent treatment has been evaluated by mainly physicians; only a limited number of prospective studies have used patient-reported outcomes for this purpose. The aim of this work was to study ... -
pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda
(Peer reviewed; Journal article, 2009-08-19)Background: The members of the retinoblastoma protein family, pRb, p107 and pRb2 (p130), are central players in controlling the cell cycle. Whereas disturbed function of pRb is commonly seen in human cancers, it is still ... -
Proliferation, lymph vessel invasion and histologic type as prognostic factors in lymph node negative breast cancer
(Doctoral thesis, 2011-12-14)Breast cancer is a leading cause of cancer mortality among women in the western world, second only to lung cancer. Since the mammography screening program in Norway started in 1995, 70% and more of all new breast cancers ...