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dc.contributor.authorWiren, Saraen_US
dc.contributor.authorHäggström, Christelen_US
dc.contributor.authorUlmer, Hannoen_US
dc.contributor.authorManjer, Jonasen_US
dc.contributor.authorBjørge, Toneen_US
dc.contributor.authorNagel, Gabrieleen_US
dc.contributor.authorJohansen, Dortheen_US
dc.contributor.authorHallmans, Göranen_US
dc.contributor.authorEngeland, Andersen_US
dc.contributor.authorConcin, Hansen_US
dc.contributor.authorJonsson, Håkanen_US
dc.contributor.authorSelmer, Randien_US
dc.contributor.authorTretli, Steinaren_US
dc.contributor.authorStocks, Tanjaen_US
dc.contributor.authorStattin, Pären_US
dc.date.accessioned2015-03-12T10:07:30Z
dc.date.available2015-03-12T10:07:30Z
dc.date.issued2013-10-31eng
dc.identifier.issn0957-5243
dc.identifier.issn1573-7225
dc.identifier.urihttps://hdl.handle.net/1956/9522
dc.description.abstractPurpose: To assess the association between height and risk of cancer and cancer death. Methods: The metabolic syndrome and cancer project is a prospective pooled cohort study of 585,928 participants from seven cohorts in Austria, Norway, and Sweden. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for cancer incidence and death were estimated in height categories and per 5-cm increment for each cancer site using Cox proportional hazards model. Results: During a mean follow-up of 12.7 years (SD = 7.2), 38,862 participants were diagnosed with cancer and 13,547 participants died of cancer. Increased height (per 5-cm increment) was associated with an increased overall cancer risk in women, HR 1.07 (95 % CI 1.06–1.09), and in men, HR 1.04 (95 % CI 1.03–1.06). The highest HR was seen for malignant melanoma in women, HR 1.17 (95 % CI 1.11–1.24), and in men HR 1.12 (95 % CI 1.08–1.19). Height was also associated with increased risk of cancer death in women, HR 1.03 (95 % CI 1.01–1.16), and in men, HR 1.03 (95 % CI 1.01–1.05). The highest HR was observed for breast cancer death in postmenopausal women (>60 years), HR 1.10 (95 % CI 1.00–1.21), and death from renal cell carcinoma in men, HR 1.18 (95 % CI 1.07–1.30). All these associations were independent of body mass index. Conclusion: Height was associated with risk of cancer and cancer death indicating that factors related to height such as hormonal and genetic factors stimulate both cancer development and progression.en_US
dc.language.isoengeng
dc.publisherSpringer International Publishingeng
dc.relation.urihttp://download.springer.com/static/pdf/659/art%253A10.1007%252Fs10552-013-0317-7.pdf?auth66=1392207675_76a6d20d9752566a979117fddc83d843&ext=.pdfeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.subjectBody statureeng
dc.subjectBody heighteng
dc.subjectEpidemiologyeng
dc.subjectCancer riskeng
dc.subjectCohort studyeng
dc.titlePooled cohort study on height and risk of cancer and cancer deathen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-03-05T09:19:35Zen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author(s) 2013. This article is published with open access at Springerlink.com
dc.identifier.doihttps://doi.org/10.1007/s10552-013-0317-7
dc.identifier.cristin1076331
dc.source.journalCancer Causes and Control
dc.source.4025
dc.source.142
dc.source.pagenumber151-159
dc.subject.nsiVDP::Medical sciences: 700::Clinical medical sciences: 750::Oncology: 762eng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Onkologi: 762nob


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