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dc.contributor.authorMellingsæter, Marteen_US
dc.contributor.authorWyller, Torgeir Bruunen_US
dc.contributor.authorRanhoff, Anette Hylenen_US
dc.contributor.authorBogdanovic, Nenaden_US
dc.contributor.authorWyller, Vegard Bruunen_US
dc.date.accessioned2015-03-31T06:39:13Z
dc.date.available2015-03-31T06:39:13Z
dc.date.issued2015-03-13eng
dc.identifier.issn1664-5464
dc.identifier.urihttps://hdl.handle.net/1956/9704
dc.description.abstractBackground: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. Methods: Noninvasive, continuous hemodynamic recordings were obtained from 14 patients and 48 controls during supine rest (tilt of 30 and 70°). Cardiac output, end-diastolic volume, total peripheral resistance, heart rate variability (HRV), systolic blood pressure variability (SBPV), and baroreceptor sensitivity were calculated. Results: At 70° tilt, the HRV indices differed significantly, with higher high-frequency (HF) variability as well as lower low-frequency (LF) variability and LF/HF ratios in the patients. The patients had significantly lower SBPV in the LF range at 30° tilt. Conclusions: The results indicate a poorer sympathetic response to orthostatic stress in MCI and mild AD.en_US
dc.language.isoengeng
dc.publisherKargereng
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/eng
dc.subjectAutonomic functioneng
dc.subjectHead-up tilteng
dc.subjectMild cognitive impairmenteng
dc.subjectAlzheimer’s dementiaeng
dc.titleReduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementiaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-03-31T06:33:11Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 S. Karger AG, Basel
dc.identifier.doihttps://doi.org/10.1159%2f000375297
dc.identifier.cristin1232038
dc.source.journalDementia and geriatric cognitive disorders extra
dc.source.405
dc.source.141
dc.source.pagenumber107-115


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