dc.contributor.author | Mellingsæter, Marte | en_US |
dc.contributor.author | Wyller, Torgeir Bruun | en_US |
dc.contributor.author | Ranhoff, Anette Hylen | en_US |
dc.contributor.author | Bogdanovic, Nenad | en_US |
dc.contributor.author | Wyller, Vegard Bruun | en_US |
dc.date.accessioned | 2015-03-31T06:39:13Z | |
dc.date.available | 2015-03-31T06:39:13Z | |
dc.date.issued | 2015-03-13 | eng |
dc.identifier.issn | 1664-5464 | |
dc.identifier.uri | https://hdl.handle.net/1956/9704 | |
dc.description.abstract | Background: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. Methods: Noninvasive, continuous hemodynamic recordings were obtained from 14 patients and 48 controls during supine rest (tilt of 30 and 70°). Cardiac output, end-diastolic volume, total peripheral resistance, heart rate variability (HRV), systolic blood pressure variability (SBPV), and baroreceptor sensitivity were calculated. Results: At 70° tilt, the HRV indices differed significantly, with higher high-frequency (HF) variability as well as lower low-frequency (LF) variability and LF/HF ratios in the patients. The patients had significantly lower SBPV in the LF range at 30° tilt. Conclusions: The results indicate a poorer sympathetic response to orthostatic stress in MCI and mild AD. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Karger | eng |
dc.rights | Attribution-NonCommercial CC BY-NC | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | eng |
dc.subject | Autonomic function | eng |
dc.subject | Head-up tilt | eng |
dc.subject | Mild cognitive impairment | eng |
dc.subject | Alzheimer’s dementia | eng |
dc.title | Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-03-31T06:33:11Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 S. Karger AG, Basel | |
dc.identifier.doi | https://doi.org/10.1159/000375297 | |
dc.identifier.cristin | 1232038 | |
dc.source.journal | Dementia and geriatric cognitive disorders extra | |
dc.source.40 | 5 | |
dc.source.14 | 1 | |
dc.source.pagenumber | 107-115 | |