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dc.contributor.authorGrimstad, Toreen_US
dc.contributor.authorBjørndal, Bodilen_US
dc.contributor.authorCacabelos, Danielen_US
dc.contributor.authorAasprong, Ole Gunnaren_US
dc.contributor.authorOmdal, Roalden_US
dc.contributor.authorSvardal, Asbjørn M.en_US
dc.contributor.authorBohov, Pavolen_US
dc.contributor.authorPamplona, Reinalden_US
dc.contributor.authorPortero-Otin, Manuelen_US
dc.contributor.authorBerge, Rolf Kristianen_US
dc.contributor.authorHausken, Trygveen_US
dc.date.accessioned2015-04-14T14:01:43Z
dc.date.available2015-04-14T14:01:43Z
dc.date.issued2013-01-10eng
dc.identifier.issn2048-6790
dc.identifier.urihttps://hdl.handle.net/1956/9785
dc.description.abstractFish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided into five groups, were included in a 4-week dietary intervention study. Of the groups, four were exposed in the fourth week to 5 % dextran sulfate sodium (DSS) to induce colitis, while one group was unexposed. The diets were: (1) control, (2) control + DSS, (3) FO (5 %) + DSS, (4) FP (3·5 %) + DSS, (5) FO + FP + DSS. Following DSS intake, weight and disease activity index (DAI) were assessed, and histological combined score (HCS), selected colonic PG, cytokines, oxidative damage markers and mRNA levels were measured. FP reduced HCS, tended to lower DAI (P = 0·07) and reduced keratinocyte chemoattractant/growth-regulated oncogene levels, as compared with the FO diet. FP also reduced mRNA levels of Il-6 and Cxcl1, although not significantly. FO intake increased the DAI as compared with DSS alone. PGE3 levels increased after the FO diet, and even more following FO + FP intake. The FP diet seems to have a protective effect in DSS-induced colitis as compared with FO. A number of beneficial, but non-significant, changes also occurred after FP v. DSS. A combined FO + FP diet may influence PG synthesis, as PGE3 levels were higher after the combined diet than after FO alone.en_US
dc.language.isoengeng
dc.publisherCambridge University Presseng
dc.rightsAttribution-NonCommercial-ShareAlike CC BY-NC-SAeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/eng
dc.subjectColitiseng
dc.subjectDiet therapyeng
dc.subjectInflammatory bowel diseaseeng
dc.subjectn-3 Fatty acidseng
dc.titleA salmon peptide diet alleviates experimental colitis as compared with fish oilen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-04-01T09:43:41Zen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2013 The Authors
dc.source.articlenumbere2
dc.identifier.doihttps://doi.org/10.1017/jns.2012.23
dc.identifier.cristin1101247
dc.source.journalJournal of Nutritional Science
dc.source.402


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