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dc.contributor.authorKleppe, Runeen_US
dc.contributor.authorMartinez, Auroraen_US
dc.contributor.authorDøskeland, Stein Oveen_US
dc.contributor.authorHaavik, Janen_US
dc.description.abstractThirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that modulate cellular and whole body energy and nutrient homeostasis. Large scale screening for cellular binding partners of 14-3-3 has identified numerous proteins that participate in regulation of metabolic pathways, although only a minority of these targets have yet been subject to detailed studies. Because of the wide distribution of potential 14-3-3 targets and the resurging interest in metabolic pathway control in diseases like cancer, diabetes, obesity and cardiovascular disease, we review the role of 14-3-3 proteins in the regulation of core and specialized cellular metabolic functions. We cite illustrative examples of 14-3-3 action through their direct modulation of individual enzymes and through regulation of master switches in cellular pathways, such as insulin signaling, mTOR- and AMP dependent kinase signaling pathways, as well as regulation of autophagy. We further illustrate the quantitative impact of 14-3-3 association on signal response at the target protein level and we discuss implications of recent findings showing 14-3-3 protein membrane binding of target proteins.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.subject14-3-3 Proteinseng
dc.subjectTyrosine hydroxylaseeng
dc.subjectMembrane associationeng
dc.subjectCell signalingeng
dc.titleThe 14-3-3 proteins in regulation of cellular metabolismen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2011 Elsevier Ltd.
dc.source.journalSeminars in Cell and Developmental Biology
dc.subject.nsiVDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715eng
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715nob

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