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dc.contributor.authorGalluzzi, Lorenzoen_US
dc.contributor.authorVitale, Ilioen_US
dc.contributor.authorSenovilla, Lauraen_US
dc.contributor.authorOlaussen, Ken Andréen_US
dc.contributor.authorPinna, Guillaumeen_US
dc.contributor.authorEisenberg, Tobiasen_US
dc.contributor.authorGoubar, Aïchaen_US
dc.contributor.authorMartins, Isabelleen_US
dc.contributor.authorMichels, Judithen_US
dc.contributor.authorKratassiouk, Guerorguien_US
dc.contributor.authorCarmona-Gutierrez, Didacen_US
dc.contributor.authorScoazec, Marieen_US
dc.contributor.authorVacchelli, Erikaen_US
dc.contributor.authorSchlemmer, Fredericen_US
dc.contributor.authorKepp, Oliveren_US
dc.contributor.authorShen, Sheshien_US
dc.contributor.authorTailler, Maximilienen_US
dc.contributor.authorNiso-Santano, Mireiaen_US
dc.contributor.authorMorselli, Eugeniaen_US
dc.contributor.authorCriollo, Alfredoen_US
dc.contributor.authorAdjemian, Sandyen_US
dc.contributor.authorJemaa, Mohameden_US
dc.contributor.authorChaba, Karimanen_US
dc.contributor.authorPailleret, Claireen_US
dc.contributor.authorMichaud, Mickaëlen_US
dc.contributor.authorPietrocola, Federicoen_US
dc.contributor.authorTajeddine, Nicolasen_US
dc.contributor.authorRouge, Thibault de La Motteen_US
dc.contributor.authorAraujo, Nataliaen_US
dc.contributor.authorMorozova, Nadyaen_US
dc.contributor.authorRobert, Thomasen_US
dc.contributor.authorRipoche, Huguesen_US
dc.contributor.authorCommo, Fredericen_US
dc.contributor.authorBesse, Benjaminen_US
dc.contributor.authorValidire, Pierreen_US
dc.contributor.authorFouret, Pierreen_US
dc.contributor.authorRobin, Angéliqueen_US
dc.contributor.authorDorvault, Nicolasen_US
dc.contributor.authorGirard, Philippeen_US
dc.contributor.authorGouy, Sébastienen_US
dc.contributor.authorPautier, Patriciaen_US
dc.contributor.authorJägemann, Noraen_US
dc.contributor.authorNickel, Ann-Christinen_US
dc.contributor.authorMarsili, Sabrinaen_US
dc.contributor.authorPaccard, Carolineen_US
dc.contributor.authorServant, Nicolasen_US
dc.contributor.authorHupé, Philippeen_US
dc.contributor.authorBehrens, Carmenen_US
dc.contributor.authorBehnam-Motlagh, Pavizen_US
dc.contributor.authorKohno, Kimitoshien_US
dc.contributor.authorCremer, Isabelleen_US
dc.contributor.authorDamotte, Dianeen_US
dc.contributor.authorAlifano, Marcoen_US
dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorLazar, Vladimiren_US
dc.contributor.authorDessen, Philippeen_US
dc.contributor.authorZischka, Hansen_US
dc.contributor.authorChatelut, Etienneen_US
dc.contributor.authorCastedo, Mariaen_US
dc.contributor.authorMadeo, Franken_US
dc.contributor.authorBarillot, Emmanuelen_US
dc.contributor.authorThomale, Jürgenen_US
dc.contributor.authorWistuba, Ignacio Ivanen_US
dc.contributor.authorSautes-Fridman, Catherineen_US
dc.contributor.authorZitvogel, Laurenceen_US
dc.contributor.authorSoria, Jean-Charlesen_US
dc.contributor.authorHarel-Bellan, Annicken_US
dc.contributor.authorKroemer, Guidoen_US
dc.date.accessioned2015-04-21T11:25:38Z
dc.date.available2015-04-21T11:25:38Z
dc.date.issued2012-08-30eng
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/1956/9828
dc.description.abstractPatients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6. In line with a general role of vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.en_US
dc.publisherElseviereng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.titlePrognostic impact of vitamin B6 metabolism in lung canceren_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-04-21T11:22:06Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2012 The Authors
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2012.06.017
dc.identifier.cristin997189
dc.source.journalCell reports
dc.source.402
dc.source.142
dc.source.pagenumber257-269


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs CC BY-NC-ND