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dc.contributor.authorHaram, Kjellen_US
dc.contributor.authorMortensen, Jan Helge Seglemen_US
dc.contributor.authorNagy, Bálinten_US
dc.date.accessioned2015-05-08T11:58:12Z
dc.date.available2015-05-08T11:58:12Z
dc.date.issued2014-06-02eng
dc.identifier.issn2090-2727
dc.identifier.urihttps://hdl.handle.net/1956/9866
dc.description.abstractBoth preeclampsia and the HELLP syndrome have their origin in the placenta. The aim of this study is to review genetic factors involved in development of preeclampsia and the HELLP syndrome using literature search in PubMed. A familial cohort links chromosomes 2q, 5q, and 13q to preeclampsia. The chromosome 12q is coupled with the HELLP syndrome. The STOX1 gene, the ERAP1 and 2 genes, the syncytin envelope gene, and the −670 Fas receptor polymorphisms are involved in the development of preeclampsia. The ACVR2A gene on chromosome 2q22 is also implicated. The toll-like receptor-4 (TLR-4) and factor V Leiden mutation participate both in development of preeclampsia and the HELLP syndrome. Carriers of the TT and the CC genotype of the MTHFR C677T polymorphism seem to have an increased risk of the HELLP syndrome. The placental levels of VEGF mRNA are reduced both in women with preeclampsia and in women with the HELLP syndrome. The BclI polymorphism is engaged in development of the HELLP syndrome but not in development of severe preeclampsia. The ACE I/D polymorphism affects uteroplacental and umbilical artery blood flows in women with preeclampsia. In women with preeclampsia and the HELLP syndrome several genes in the placenta are deregulated. Preeclampsia and the HELLP syndrome are multiplex genetic diseases.en_US
dc.language.isoengeng
dc.publisherThe University of Bergeneng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.titleGenetic aspects of preeclampsia and the HELLP syndromeen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-04-09T06:17:41Zen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 Kjell Haram et al.
dc.source.articlenumber910751
dc.identifier.doihttps://doi.org/10.1155/2014/910751
dc.identifier.cristin1154245
dc.source.journalJournal of Pregnancy
dc.source.402014
dc.subject.nsiVDP::Medical sciences: 700::Clinical medical sciences: 750::Gynaecology and obstetrics: 756eng
dc.subject.nsiVDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714eng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756nob
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714nob


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