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dc.contributor.authorHaldorsen, Ingfrid S.en_US
dc.contributor.authorStefansson, Ingunnen_US
dc.contributor.authorGrüner, Renateen_US
dc.contributor.authorHusby, Jenny Hild Aaseen_US
dc.contributor.authorMagnussen, Inger Johanneen_US
dc.contributor.authorWerner, Henrica Maria Johannaen_US
dc.contributor.authorSalvesen, Øyvinden_US
dc.contributor.authorBjørge, Lineen_US
dc.contributor.authorTrovik, Joneen_US
dc.contributor.authorTaxt, Torfinnen_US
dc.contributor.authorAkslen, Lars A.en_US
dc.contributor.authorSalvesen, Helga Birgitteen_US
dc.description.abstractBackground: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and to explore the potential value of these markers to identify patients with poor outcome. Methods: In fifty-four surgically staged endometrial carcinoma patients, immunohistochemical staining with factor VIII and Ki67 allowed assessment of microvessel density (MVD) and microvascular proliferation reflecting tumour angiogenesis. In the same patients, preoperative pelvic DCE-MRI and DWI allowed the calculation of parameters describing tumour microvasculature and microstructure in vivo. Results: Microvascular proliferation was negatively correlated to tumour blood flow (Fb) (r=−0.36, P=0.008), capillary permeability surface area product (PS) (r=−0.39, P=0.004) and transfer from the blood to extravascular extracellular space (EES) (Ktrans) (r=−0.40, P=0.003), and was positively correlated to tumour volume (r=0.34; P=0.004). High-tumour microvascular proliferation, low Fb and low Ktrans were all significantly associated with reduced progression/recurrence-free survival (P<0.05). Conclusion: Disorganised angiogenesis with coexisting microvascular proliferation and low tumour blood flow is a poor prognostic factor supporting that hypoxia is associated with progression and metastatic spread in endometrial carcinomas.en_US
dc.publisherNature Publishing Groupeng
dc.rightsAttribution-NonCommercial-ShareAlike CC BY-NC-SAeng
dc.subjectendometrial carcinomaeng
dc.subjecthistomorphological markereng
dc.subjectdynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)eng
dc.subjectdiffusion-weighted imaging (DWI)eng
dc.titleIncreased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomasen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 Cancer Research UK
dc.source.journalBritish Journal of Cancer
dc.relation.projectNorges forskningsråd: 223250
dc.relation.projectNorges forskningsråd: 191778
dc.relation.projectNorges forskningsråd: 205404
dc.subject.nsiVDP::Medical sciences: 700::Clinical medical sciences: 750::Gynaecology and obstetrics: 756eng
dc.subject.nsiVDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715eng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756nob
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715nob

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