• Anti-depressive effectiveness of olanzapine, quetiapine, risperidone and ziprasidone: a pragmatic, randomized trial 

      Kjelby, Eirik; Jørgensen, Hugo A.; Kroken, Rune A.; Løberg, Else-Marie; Johnsen, Erik (Peer reviewed; Journal article, 2011-08-31)
      Background: Efficacy studies indicate anti-depressive effects of at least some second generation antipsychotics (SGAs). The Bergen Psychosis Project (BPP) is a 24-month, pragmatic, industry-independent, randomized, head-tohead ...
    • Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study 

      Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Nhat Trung, Doan; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Schizophrenia Project (KaSP), Karolinska; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2020)
      Background Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations ...
    • Cognitive change and antipsychotic medications: Results from a pragmatic rater-blind RCT 

      Anda, Liss; Johnsen, Erik; Kroken, Rune A.; Joa, Inge; Rettenbacher, Maria; Løberg, Else-Marie (Journal article; Peer reviewed, 2021)
      Cognitive impairment is a core aspect of psychotic disorders and difficult to treat. Atypical antipsychotics (AAs) might have differential effects on cognitive impairment, but rigid study designs and selective sampling ...
    • Cognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated norms 

      Anda-Ågotnes, Liss Gøril; Brønnick, Kolbjørn Kallesten; Johannessen, Jan Olav; Joa, Inge; Kroken, Rune Andreas; Johnsen, Erik; Rettenbacher, Maria; Fathian, Farivar; Løberg, Else-Marie (Peer reviewed; Journal article, 2019-10-01)
      Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized ...
    • Dynamic Functional Connectivity Patterns in Schizophrenia and the Relationship With Hallucinations 

      Weber, Sarah; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2020)
      There is a wealth of evidence showing aberrant functional connectivity (FC) in schizophrenia but with considerable variability in findings across studies. Dynamic FC is an extension of traditional static FC, in that such ...
    • GABA, glutamatergic dynamics and BOLD contrast assessed concurrently using functional MRS during a cognitive task 

      Craven, Alexander R.; Dwyer, Gerard Eric; Ersland, Lars; Kazimierczak, Katarzyna Anna; Noeske, Ralph; Sandøy, Lydia Brunvoll; Johnsen, Erik; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2023)
      A recurring issue in functional neuroimaging is how to link task-driven haemodynamic blood oxygen level dependent functional MRI (BOLD-fMRI) responses to underlying neurochemistry at the synaptic level. Glutamate and ...
    • Glutamate- and GABA-Modulated Connectivity in Auditory Hallucinations—A Combined Resting State fMRI and MR Spectroscopy Study 

      Weber, Sarah; Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Kompus, Kristiina; Hugdahl, Kenneth (Journal article; Peer reviewed, 2021)
      Background: Auditory verbal hallucinations (AVH) have been linked to aberrant interhemispheric connectivity between the left and the right superior temporal gyrus (STG), labeled the interhemispheric miscommunication theory. ...
    • Intra-Regional Glu-GABA vs Inter-Regional Glu-Glu Imbalance: A 1H-MRS Study of the Neurochemistry of Auditory Verbal Hallucinations in Schizophrenia. 

      Hjelmervik, Helene; Craven, Alexander R.; Sinkeviciute, Igne; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Gruner, Eli Renate; Hugdahl, Kenneth (Peer reviewed; Journal article, 2019-10-18)
      Glutamate (Glu), gamma amino-butyric acid (GABA), and excitatory/inhibitory (E/I) imbalance have inconsistently been implicated in the etiology of schizophrenia. Elevated Glu levels in language regions have been suggested ...
    • Mapping psychotic-like experiences: Results from an online survey 

      Kusztrits, Isabella; Larøi, Frank; Laloyaux, Julien Freddy; Marquardt, Lynn Anne; Sinkeviciute, Igne; Kjelby, Eirik; Johnsen, Erik; Sommer, Iris Else Clara; Hugdahl, Kenneth; Hirnstein, Marco (Journal article; Peer reviewed, 2021)
      Suggestions have been made that psychotic‐like experiences (PLEs), such as hallucinatory and delusional experiences, exist on a continuum from healthy individuals to patients with a diagnosis of schizophrenia. We used the ...
    • Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients 

      Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Sinkeviciute, Igne; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Grüner, Eli Renate; Sommer, Iris E.; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2021)
      Objectives Negative emotional valence of auditory verbal hallucinations (AVHs) in schizophrenia can be a source of distress and is considered a strong predictor of illness severity. Previous studies have found glutamate ...
    • Neural activation in the ventromedial prefrontal cortex precedes conscious experience of being in or out of a transient hallucinatory state 

      Hugdahl, Kenneth; Craven, Alexander R.; Johnsen, Erik; Ersland, Lars; Stoyanov, Drozdstoy; Kandilarova, Sevdalina; Sandøy, Lydia Brunvoll; Kroken, Rune A.; Løberg, Else-Marie; Sommer, Iris E. (Journal article; Peer reviewed, 2022)
      Background and Hypotheses Auditory verbal hallucinations (AVHs) is not only a common symptom in schizophrenia but also observed in individuals in the general population. Despite extensive research, AVHs are poorly understood, ...
    • Pilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulation 

      Marquardt, Lynn Anne; Craven, Alexander R.; Hugdahl, Kenneth Jan; Johnsen, Erik; Kroken, Rune Andreas; Kusztrits, Isabella; Specht, Karsten; Thomassen, Anne Synnøve; Weber, Sarah; Hirnstein, Marco (Journal article; Peer reviewed, 2022-10-12)
      Background: Transcranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS increases activity in prefrontal cognitive control ...
    • The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations 

      Kompus, Kristiina; Falkenberg, Liv Eggset; Bless, Josef J; Johnsen, Erik; Kroken, Rune; Kråkvik, Bodil; Larøi, Frank; Løberg, Else-Marie; Vedul-Kjelsås, Einar; Westerhausen, René; Hugdahl, Kenneth (Peer reviewed; Journal article, 2013-04-24)
      Auditory verbal hallucinations (AVHs) are a subjective experience of “hearing voices” in the absence of corresponding physical stimulation in the environment. The most remarkable feature of AVHs is their perceptual quality, ...